Pudge
* Legion Commander can use 
Press the Attack on an ally to dispel Dismember. The bonus health regeneration also partially counters the damage of Rot
* 
Duel can be used on Pudge whilst Rot is active, disabling toggling which may result in a lethal health drain that leaves Legion Commander with a successful duel.
Nyx Assassin
* Duel's long duration prevents Nyx Assassin escaping from 
Vendetta. With Aghanim's Scepter, she can also bypass 
Spiked Carapace.
Pudge
* The lifesteal of 
Feast scales accordingly to the max health of its target, which is effective against Pudge due to his high health and further health granted by stacks of Flesh Heap.
* Lifestealer can activate 
Rage to be spell immune, making Rot deal no damage.
* Pudge's plentiful health makes him an ideal target for Lifestealer's 
Aghanim's Shard ability, 
Open Wounds.
Nyx Assassin
* Rage allows Lifestealer to freely attack Nyx Assassin and hunt him down if Vendetta is on cooldown. Nyx Assassin cannot counter Rage with Spiked Carapace because Rage gives Lifestealer spell immunity. And besides Vendetta, Nyx Assassin has no other way of dealing damage to Lifestealer while he is spell immune.
* Open Wounds from Aghanim's Shard allows Lifestealer to severely slow down Nyx Assassin while also allowing his team to recover themselves while attacking Nyx Assassin. Open Wounds can also fester and spread if Nyx Assassin takes enough damage that will trigger the spread while he is affected with Open Wounds.
* 
Infest combined with an ancient creep makes Nyx Assassin an easy target to surprise with 
Dust of Appearance or a 
Gem of True Sight. 
Aghanim's Scepter upgraded Infest can also allow Lifestealer to infest, disarm and freely attack Nyx Assassin from within. and Nyx Assassin cannot counter this with Spiked Carapace because Lifestealer is invulnerable while attacking the infested enemy hero from within.
* Overall, any attempt for Nyx Assassin to gank and kill Lifestealer will hurt Nyx Assassin more than Lifestealer.
Additional:
* Like with Juggernaut's 
Blade Fury, Rage allows Lifestealer to freely attack Nyx Assassin and hunt him down if Vendetta is on cooldown. Nyx Assassin cannot counter Rage with Spiked Carapace because Rage gives Lifestealer spell immunity. And besides Vendetta, Nyx Assassin has no other way of dealing damage to Lifestealer while he is spell immune.
* Open Wounds from Aghanim's Shard allows Lifestealer to severely slow down Nyx Assassin while also allowing his team to recover themselves while attacking Nyx Assassin. Open Wounds can also fester and spread if Nyx Assassin takes enough damage that will trigger the spread while he is affected with Open Wounds.
* Infest combined with an ancient creep makes Nyx Assassin an easy target to surprise with Dust of Appearance or a Gem of True Sight. And similarly to Juggernaut's 
Omnislash and 
Swiftslash from Aghanim's Scepter, Aghanim's Scepter upgraded Infest can also allow Lifestealer to infest, disarm and freely attack Nyx Assassin from within. And Nyx Assassin cannot counter this with Spiked Carapace because Lifestealer is invulnerable while attacking the infested enemy hero from within.
* Like with Juggernaut, any attempt for Nyx Assassin to gank and kill Lifestealer will hurt Nyx Assassin more than Lifestealer.
Pudge
* Bounty Hunter can easily keep vision on Pudge with Track, making it difficult for Pudge to hook Bounty Hunter or his team mates.
* It's difficult for Pudge to keep up with Bounty Hunter to apply 
Rot on him due to Shadow Walk.
* Shuriken Toss cancels out 
Dismember from a good range if Bounty Hunter is not the target.
Additional:
* 
Track can easily keep vision on Pudge, making it very hard for him to hook Bounty Hunter or his teammates from the fog of war.
* 
Shuriken Toss cancels Dismember from great range.
Nyx Assassin
* Nyx Assassin wants to start ganking as soon as he gets his Vendetta. Keeping him Tracked prevents him from ganking, and thus from doing his job in the game.
* Nyx Assassin has a lot of armor and health regen, making the nuke damage from Shuriken Toss very good against him.
Additional:
* Track hinders Nyx Assassin's ganking and escaping attempts with Vendetta, making him an easy kill for gold as well.
* Bounty Hunter can also use Track on Nyx Assassin while he has Spiked Carapace active without getting stunned as Track deals no damage at all before using Shuriken Toss.
Pudge
* 
Corrosive Haze reveals Pudge's location, making it hard for him to use Meat Hook from the fog of war on Slardar's teammates or Slardar himself.
* 
Slithereen Crush interrupts Pudge while he is using Dismember.
* 
Guardian Sprint allows Slardar to avoid Meat Hook.
Additional:
* While Slardar has Guardian Sprint activated, Rot cannot slow him and 
Meat Hook is easier to avoid.
* Slithereen Crush allows Slardar to interrupt Dismember at close range (when Slardar is not a target).
* Corrosive Haze reveals Pudge's location, making it very difficult for him to land hooks from the fog.
Nyx Assassin
* Corrosive Haze hinders Nyx Assassin's ganking attempts with Vendetta, as well as reducing his armor and make him very vulnerable due to his low health pool.
* Guardian Sprint allows Slardar to catch up with Nyx Asssassin and finish him off if he has vision over him.
Pudge
* 
Infernal Blade deals high damage to Pudge due to his scaling health and strength gain from 
Flesh Heap.
* Using 
Doom with timing against Pudge who had just activated Rot would usually kill him.
Additional:
* Doom disables the toggling of Rot and, if cast at the right time, may leave Pudge with a potentially lethal health drain.
* Doom's naturally high health, strength gain and damage output makes him a poor target for Pudge.
* The damage of Doom's Infernal Blade scales with the target's maximum health, which is particularly effective against Pudge due to his naturally high health and further health granted by stacks of Flesh Heap.
Nyx Assassin
* A well-timed Doom prevents Nyx Assassin escaping with Vendetta and fighting back with Spiked Carapace.
* Doom's high health also allows him to easily shrug off Nyx Assassin's burst damage and fend him off.
Pudge
* 
Dark Pact dispels Dismember if timed correctly.
* 
Pounce allows Slark to escape Pudge's Rot once Dismember is over, and allows him to dodge hooks.
* 
Shadow Dance hides Slark and grants him a high degree of mobility, which can make him a difficult target to hook and also protects him from Pudge's Dismember (including allies with an Aghanim's Shard).
Nyx Assassin
* Heroes who build 
Black King Bar as either core or situational item will be able to fight back against Nyx Assassin and freely attack him as Spiked Carapace cannot pierce spell immunity at all: 
Axe, 
Broodmother, 
Dawnbreaker, 
Enigma, 
Huskar, 
Jakiro, 
Legion Commander, 
Lina, 
Luna, 
Lycan, 
Slardar, 
Slark, 
Troll Warlord, 
Witch Doctor.
Pudge
* If Meat Hook is used before 
Blink, Anti-Mage may be able to escape Pudge's grasp by blinking to safety.
* 
Counterspell grants Anti-Mage a large degree of magic resistance, a damage type Pudge is highly reliant on to secure kills. This makes Anti-Mage a bad target for Pudge. The active can also block Dismember if timed correctly.
* 
Mana Break can quickly drain Pudge's low supply of mana, which may render Meat Hook and Dismember unusable.
Nyx Assassin
* Heroes who build mana boosting items but have low mana regeneration are especially vulnerable against Mana Break and Mana Void: 
Timbersaw, Slark, 
Shadow Fiend, 
Clinkz, 
Bristleback 
Nyx Assassin, 
Magnus
Pudge
* Heroes that have a weak laning stage: 
Spectre, Nyx Assassin, 
Clockwerk, 
Spirit Breaker, 
Omniknight, 
Pudge.
Additional:
* 
Void's mini-stun and silence from 
Crippling Fear will stop Pudge from using Dismember or turning off his Rot.
* Night Stalker has naturally high health, strength gain and common itemization for survivability through magic resistance, making Night Stalker a poor target for Pudge.
Nyx Assassin
* Heroes that have a weak laning stage: Spectre, Nyx Assassin, Clockwerk, Spirit Breaker, Omniknight, Pudge.
Pudge
* Heroes with channeling spells are very easy targets for Jakiro's abilities: 
Crystal Maiden, Dawnbreaker, Enigma, Pudge, Shadow Fiend, 
Shadow Shaman, 
Warlock.
Nyx Assassin
* Heroes who rely on damage over time as Spiked Carapace can block and reflect only one instance of damage: Jakiro, 
Viper, 
Venomancer, Huskar, 
Ember Spirit, 
Dark Seer, 
Sand King, 
Doom, Dawnbreaker. However, this also means they are easily stunned.
Pudge
* Any heroes that naturally buy 
Diffusal Blade like 
Phantom Lancer or have a mana break talent is a big issue for Pudge because of his low mana pool.
Nyx Assassin
* Nyx Assassin's skillset is mostly single-targeted, therefore he will have difficulties against heroes with illusions and summons: 
Naga Siren, Broodmother, Lycan, 
Visage, Phantom Lancer. And to make things worse, Nyx Asassin is not a common 
Battle Fury, 
Maelstrom, 
Mjollnir, 
Gleipnir or 
Radiance wielder to counter this problem.
Pudge
* Abaddon's constant heals and protection can save himself and his allies from burst-focused heroes, such as Legion Commander, 
Faceless Void, and Pudge.
Additional:
* Abaddon can activate 
Borrowed Time to dispel Dismember; breaking the disable and potentially allowing Abaddon to escape.
* 
Aphotic Shield can be cast on an ally to dispel the stun of Dismember, which can make kills difficult to secure, given that Dismember is Pudge's only reliable disable.
* Pudge lacks a mobility without a 
Blink Dagger, causing him to be easily chased with 
Curse of Avernus. The silence also prevents him from toggling off his Rot.
Nyx Assassin
* 
Impale and Spiked Carapace stun can be instantly dispelled by Aphotic Shield.
* Abaddon can use Borrowed Time and easily heal for the duration of Borrowed Time by Nyx's burst damage.
Nyx Assassin
* Nyx Assassin might not kill Abaddon with his nuke, but a support Abaddon will struggle to protect an ally from him.
Pudge
* Low armor and lack of escape makes Pudge vulnerable to Ursa, specially when he gets his Blink Dagger.
* If Pudge lands a Meat Hook on Ursa, Ursa can simply face Pudge head on provided he can burst him down before any follow up disables.
* Enrage's Aghanim's Scepter upgrade allows Ursa to dispel Pudge's Dismember.
Nyx Assassin
* A well-timed 
Berserker's Call can expose Nyx Assassin while he is invisible with Vendetta, and prevent him from using Spiked Carapace.
* Axe can use 
Battle Hunger's damage over time to minimialize effects of Spiked Carapace.
* Axe's high health also allows him to easily shrug off Nyx Assassin's burst damage and fend him off. Especially since Axe is a common 
Heart of Tarrasque wielder, which can completely eliminate any chance for Nyx Assassin to kill Axe alone.
* 
Culling Blade can often kill Nyx Assassin as he is very fragile and vulnerable to damage while Spiked Carapace is on cooldown.
Additional:
* A well-timed Berserker's Call can expose Nyx Assassin while he is invisible with Vendetta, and prevent him from using Spiked Carapace.
* Axe can use Battle Hunger's damage over time to minimialize effects of Spiked Carapace.
* Axe's high health also allows him to easily shrug off Nyx Assassin's burst damage and fend him off. Especially since Axe is a common Heart of Tarrasque wielder, which can completely eliminate any chance for Nyx Assassin to kill Axe alone.
* Culling Blade can often kill Nyx Assassin as he is very fragile and vulnerable to damage while Spiked Carapace is on cooldown.
Nyx Assassin
* Centaur's low Intelligence makes 
Mind Flare do low damage.
* With some creative skill builds, Centaur's Hoof Stomp stun duration should always last longer than Spiked Carapace stun, so escaping unscathed is hard for Nyx.
* With Blink Dagger and detection, Centaur can devastate Nyx in the open.
* However, bear in mind that Nyx can also easily initiate on Centaur Warrunner as well if he uses Spiked Carapace in anticipation, and with Vendetta. The damage from Retaliate will be reflected back to Centaur Warrunner, stunning him with no chance to react after he's revealed himself, and should guarantee a successful Impale.
Pudge
* Meat Hooking a Clockwerk can backfire for Pudge, as Battery Assault and 
Blade Mail will hurt Pudge more than he hurts Clockwerk.
Pudge
* Earth Spirit can easily disrupt Dismember because he can disable from a long distance with a Stone Remnant and Rolling Boulder. With talent he can even pull his teammates out of Dismember and also silence Pudge with Geomagnetic Grip.
Nyx Assassin
* 
Corrosive Skin minimizes the damage from Impale and Mind Flare, and anything else Nyx Assassin tries to throw at Viper.
* Nyx Assassin cannot survive several poison damage-over-time output from 
Poison Attack, 
Nethertoxin, Corrosive Skin and 
Viper Strike, not even while he has Spiked Carapace active. And to make things worse, Nyx Assassin is not a common 
Silver Edge wielder to counter this problem at all.
Additional:
* Corrosive Skin minimizes the damage from Impale and Mind Flare, and anything else Nyx Assassin tries to throw at Viper.
* Nyx Assassin cannot survive several poison damage-over-time output from Poison Attack, Nethertoxin, Corrosive Skin and Viper Strike, not even while he has Spiked Carapace active. And to make things worse, Nyx Assassin is not a common Silver Edge wielder to counter this problem at all.
Nyx Assassin
* 
Cyclone from Storm in 
Primal Split can waste Nyx's Spiked Carapace, since its duration is shorter than the Cyclone's.
Pudge
* The percentage-based primary-attribute reduction effect of 
Whirling Death can be devastating for Pudge due to his high strength gain through Flesh Heap.
* 
Reactive Armor's health regeneration and common itemization for magic resistance and durability makes Timbersaw a poor target for Pudge.
* 
Timber Chain's high mobility makes it difficult for Pudge to hook or deal much Rot damage to Timbersaw.
Pudge
* Meat Hook can prove annoying for Pudge if Rubick 
Spell Steals it, allowing Rubick to easily hook and save his allies being Dismembered.
Nyx Assassin
* Lycan's high health allows him to easily shrug off Nyx Assassin's burst damage and fend him off.
* As Lycan commonly buys Black King Bar, he can use it to freely attack Nyx Assassin and chase after him with 
Shapeshift.
* Lycan can also use his wolves from 
Summon Wolves to attack Nyx Assassin while he has Spiked Carapace active without getting stunned himself.
Pudge
* Phantasm's illusions make it difficult to land Meat Hook and Dismember.
* Chaos Bolt is a comparatively low cooldown tool to interrupt Dismember.
* Chaos Strike's lifesteal offsets Rot's damage.
Additional:
* Unlike any other illusion heroes, Chaos Knight is the worst target for Pudge to hook as it will definitely backfire him.
* 
Phantasm are significantly tankier than most illusion and deal full damage, which will quickly kill Pudge due to his low armor.
* it becomes worse if pudge is affected with 
Reality Rift, which reduces his already abysmal base armor even lower.
* Low movement speed and low mobility means Pudge will struggle to escape or outrun Chaos Knight in most cases.
Nyx Assassin
* Dragon Knight's heavy armor negates Vendetta's burst physical damage. His large HP pool also gives him a good chance of surviving Nyx Assassin's follow-up nuke damage.
Pudge
* Bristleback is one of the hardest heroes to gank with a Meat Hook and Dismember combo, and attempts to do so sometimes backfire on Pudge.
Additional:
* Pudge is particularly susceptible to Bristleback's 
Viscous Nasal Goo and 
Quill Spray due to his naturally low armor and poor agility gain.
* Bristleback, in combination with his strength gain, high health, common itemization for magic resistance and damage reduction from 
Bristleback makes him a poor target for Pudge.
Pudge
* 
Tag Team easily overwhelms Pudge, as he has low armor, which when combined with heroes with strong physical damage and Pudge's slow speed, it becomes for Pudge difficult to escape.
* 
Snowball can save a Dismembered ally and stop Pudge's Dismember.
* 
Walrus PUNCH! will removes a big chunk of Pudge's health and stun him.
* Pudge usually can't stand toe to toe against Tusk and his allies in the early game.
Pudge
* His low armor deters him from a trade,while 
Jingu Mastery allows Monkey King to retaliate.
* Buffed 
Boundless Strike heals Monkey King and can potentially execute Pudge.
* Monkey King can scout Pudge's positioning from the trees, making it easier for him and his allies to dodge Meat Hook.
* With a better-than-average strength gain, he usually survives Pudge's combo.
Pudge
* Generally heroes who don't rely on magical damage, such as 
Sven, 
Phantom Assassin, and 
Outworld Destroyer, as they can practically ignore Flesh Heap's damage block.
Nyx Assassin
* With Aghanim's Scepter, Broodmother will gain access to 
Spinner's Snare, which will allow her to create invisible lines on her webs from 
Spin Web that will root, deal damage over time, and reveal enemy heroes if they unwittingly step on them. This allows Broodmother to keep her allies alerted on heroes who rely on invisibility-themed and movement-themed abilities and items to surprise enemy heroes and disrupt ganking attempts of enemy heroes: Phantom Assassin, Nyx Assassin, 
Mirana, 
Bounty Hunter, 
Templar Assassin, 
Riki, Spirit Breaker, 
Anti-Mage, 
Tusk, 
Ursa, 
Nature's Prophet, Enigma, 
Void Spirit, Magnus etc.
Nyx Assassin
* Heroes with invisibility will be detected by Thirst when they have low enough health: Bounty Hunter, Templar Assassin, Riki, Clinkz, 
Weaver, 
Treant Protector, Nyx Assassin.
Additional:
* While Burrowing, Nyx is an easy target for a 
Blood Rite, and his only way to counter it is a well-timed Spiked Carapace.
* 
Thirst is always a threat to Nyx Assassin, hindering his attempt of escape using Vendetta and rendering him unable to surprise Bloodseeker's allies.
* 
Rupture also prevents Nyx Assassin from escaping with Vendetta, as it forces him to stay still.
Pudge
* Anti-Tank heroes like: 
Razor, 
Necrophos, 
Undying.
Nyx Assassin
* Heroes who rely on damage over time as Spiked Carapace can block and reflect only one instance of damage: Jakiro, Viper, Venomancer, Huskar, Ember Spirit, Dark Seer, Sand King, Doom, Dawnbreaker. However, this also means they are easily stunned.
Pudge
* Heroes with a high degree of mobility and invisibility are hard to catch with Meat Hook: Ember Spirit, Riki, Clinkz, 
Queen of Pain.
Pudge
* Heroes with channeled abilities can be interrupted by a long-range Fissure: Crystal Maiden, Witch Doctor, 
Bane, 
Pugna, Pudge.
Nyx Assassin
* Heroes who build Black King Bar as either core or situational item will be able to fight back against Nyx Assassin and freely attack him as Spiked Carapace cannot pierce spell immunity at all: Axe, Broodmother, Dawnbreaker, Enigma, Huskar, Jakiro, Legion Commander, Lina, Luna, Lycan, Slardar, Slark, Troll Warlord, Witch Doctor.
Pudge
* Anti-Tank heroes like: Razor, Necrophos, Undying.
Pudge
* Heroes with a high degree of mobility and invisibility are hard to catch with Meat Hook: Ember Spirit, Riki, Clinkz, Queen of Pain.
Pudge
* Luna can easily cancel channeling spells with 
Lucent Beam and 0.25s Eclipse Lucent Ministun talent for 
Eclipse, she can also buy 
Abyssal Blade in case they decide to buy Black King Bar: Enigma's 
Black Hole, Witch Doctor's 
Death Ward, Shadow Shaman's 
Shackles, 
Lion's 
Mana Drain, Bane's 
Fiend's Grip, Pudge's Dismember, Crystal Maiden's 
Freezing Field, Pugna's 
Life Drain, Dawnbreaker's 
Solar Guardian, and Naga Siren's 
Reel In from Aghanim's Scepter.
Nyx Assassin
* Even though Nyx Assassin can easily kill Luna with his high burst damage, Luna can also do the same to him if he is not careful.
* Lucent Beam can deal a fair amount of damage to Nyx Assassin if he has no Spiked Carapace available to use. Although Luna should be patient using Lucent Beam on Nyx Assassin when he uses Spiked Carapace.
* As Luna commonly buys Black King Bar, she can use it to freely attack Nyx Assassin whenever he tries to defend himself with Spiked Carapace during teamfights. Luna can also buy 
Eye of Skadi and 
Manta Style to survive Nyx Assassin's burst damage and distract him.
* Though Vendetta can deal serious damage to Luna and avoid Eclipse, smart Luna will always buy Dust of Appearance to provide vision on Nyx Assassin to her and her team.
Additional:
* Even though Nyx Assassin can easily kill Luna with his high burst damage, Luna can also do the same to him if he is not careful.
* Lucent Beam can deal a fair amount of damage to Nyx Assassin if he has no Spiked Carapace available to use. Although Luna should be patient using Lucent Beam on Nyx Assassin when he uses Spiked Carapace.
* As Luna commonly buys Black King Bar, she can use it to freely attack Nyx Assassin whenever he tries to defend himself with Spiked Carapace during teamfights. Luna can also buy Eye of Skadi and Manta Style to survive Nyx Assassin's burst damage and distract him.
* Though Vendetta can deal serious damage to Luna and avoid Eclipse, smart Luna will always buy Dust of Appearance to provide vision on Nyx Assassin to her and her team.
Pudge
* Even with Black King Bar, Pudge's Meat Hook and Dismember can still disable Luna for a fairly long time.
* Many stacks of Flesh Heap will make it difficult for Luna to burst down Pudge with Eclipse. Aghanim's Shard upgraded Dismember can also allow Pudge to save an allied hero from being killed by Eclipse.
* Bear in mind, however, that Luna can cancel Dismember if some of her allies are targets. Which may force Pudge to buy Black King Bar earlier.
* For the same reasons, Pudge makes a very powerful ally for Luna when they are in the same team.
Pudge
* Heroes with powerful channeling abilities are easily interrupted by Phantom's Embrace: Bane, Pudge, Witch Doctor, Crystal Maiden, Enigma.
Nyx Assassin
* Nyx Assassin's skillset is mostly single-targeted, therefore he will have difficulties against heroes with illusions and summons: Naga Siren, Broodmother, Lycan, Visage, Phantom Lancer. And to make things worse, Nyx Asassin is not a common Battle Fury, Maelstrom, Mjollnir, Gleipnir or Radiance wielder to counter this problem.
Pudge
* Heroes that cannot move in fights such as a Dueling Legion Commander or anyone channeling a spell like Bane, Pudge, or Enigma are easy Sacred Arrow targets.
Additional:
* If Meat Hook is used before 
Leap, Mirana may be able to escape Pudge's grasp by leaping to safety.
* The invisibility from 
Moonlight Shadow gives a degree of mobility, which can make Mirana or her teammates difficult targets to hook.
* 
Sacred Arrow can be used to cancel Dismember from long distances.
Nyx Assassin
* Heroes who rely on damage over time as Spiked Carapace can block and reflect only one instance of damage: Jakiro, Viper, Venomancer, Huskar, Ember Spirit, Dark Seer, Sand King, Doom, Dawnbreaker. However, this also means they are easily stunned.
Nyx Assassin
* Some abilities deals damage from an independent source and not from the hero itself, so Nyx cannot counter them with Spiked Carapace: illusions or summoning units, 
Homing Missile, 
Nimbus, 
Mass Serpent Ward, Death Ward and especially 
Techies's mines.
Pudge
* Tether and Overcharge makes it much harder for Pudge to kill a target with Meat Hook, and Relocate can save the Io's ally while Dismember is being channeled.
Nyx Assassin
* Heroes with either magical, physical or pure damage burst: Bane, Ember Spirit, 
Leshrac, Lina, Luna, Nyx Assassin, Phantom Assassin, 
Skywrath Mage, 
Tinker, Ursa, Void Spirit.
Pudge
* Heroes with a high degree of mobility and invisibility are hard to catch with Meat Hook: Ember Spirit, Riki, Clinkz, Queen of Pain.
Nyx Assassin
* Heroes who rely on damage over time as Spiked Carapace can block and reflect only one instance of damage: Jakiro, Viper, Venomancer, Huskar, Ember Spirit, Dark Seer, Sand King, Doom, Dawnbreaker. However, this also means they are easily stunned.
Nyx Assassin
* With Vendetta, Nyx Assassin can move closely to Ember Spirit when he's farming with his Flame Guard and use Spiked Carapace with Impale to provide a reliable and long disable.
Additional:
* Spiked Carapace can be easily triggered by 
Flame Guard or Battle Fury, setting up a deadly Impale.
Pudge
* Meat Hook can be used immediately after 
Mortimer Kisses since Snapfire is forced to stay in place.
Nyx Assassin
* Spiked Carapace stops Snapfire's Mortimer Kisses.
Pudge
* Pudge's high health and damage block from Flesh Heap make him difficult for Muerta to burst.
* Pudges high magical damage from Meat Hook and Dismember can quickly burst down Muerta, especially in 
Pierce The Veil and even through Black King Bar.
* Muerta has no escape abilities and is slow, making her an easy target for Pudge's Meat Hook and Rot.
* Pudge can prevent an ally from being attacked by 
Gunslinger if he has Aghanim's Shard.
Nyx Assassin
* Nyx Assassin's high burst damage, excellent ganking potential and multiple disables pose a threat to Muerta at all stages of the game.
* Mind Flare allows Nyx Assassin to take advantage of Muerta's high intelligence and make a short work of her low health.
* Spiked Carapace and Vendetta allow Nyx to escape or initiate well against Muerta's low mobility.
* As with most retaliation based abilities, Spiked Carapace can easily take advantage of Gunslinger's stray shots.
* However, Muerta is a natural Black King Bar wielder. And if she succeeds to activate it before Nyx Assassin can ambush her, he will go down very quickly against Muerta as Spiked Carapace cannot pierce through debuff immunity at all.
Pudge
* Sniper has a low health pool and strength gain, making him vulnerable to Pudge's magical and pure damage.
* Sniper usually likes to deal damage away from the fight, and Meat Hook is capable of bringing him to the front lines.
* 
Assassinate won't do much damage against Pudge because of his high strength gain and the strength bonuses from Flesh Heap.
* 
Shrapnel will be mostly blocked by Flesh Heap's active.
Additional:
* Pudge's Meat Hook allows him to bring Sniper in the middle of any fight, and the pure damage does well against his high armor and low health.
* Dismember can lock Sniper down, which makes him highly vulnerable and gives enough time for Pudge to kill him alone. Aghanim's Shard upgraded Dismember will also allow Pudge to save an ally from Assassinate.
Nyx Assassin
* Assassinate is easy to reflect with Spiked Carapace for massive damage.
* Shrapnel's area damage can set up an easy stun with Spiked Carapace, especially when combined with Vendetta.
* In the early game, Sniper's low health pool and high intelligence makes him easy prey for Nyx Assassin.
Pudge
* Even with Black King Bar or 
Linken's Sphere, Pudge's Meat Hook can still cancel Crystal Maiden's Freezing Field as she is a very easy target while channeling it.
* Pudge's Rot can make Crystal Maiden's already bad movement speed even worse.
* Many stacks of Flesh Heap will make it nearly impossible for Crystal Maiden to kill Pudge.
* Pudge's Dismember can also be used to cancel Crystal Maiden's Freezing Field, and alternatively, Pudge can also use it to save allies from getting killed by Crystal Maiden and heal them when upgraded with Aghanim's Shard.
* Crystal Maiden is prone to ganks in the lane or in the off-lane without proper vision. Pudge can take advantage of Crystal Maiden's lack of mobility, and gank her often.
Additional:
* Meat Hook can cancel Freezing Field, even if Crystal Maiden has 
Glimmer Cape.
* She is also slow and fragile, making her a good target for ganking.
Nyx Assassin
* Crystal Maiden has a very bad movement speed, so Impale is easy to land against her. Furthermore, even while trapped by Frostbite, Nyx Assassin can still cast Impale.
* Crystal Maiden has very low armor, so Vendetta is very effective.
* Nyx Assassin has two ways to stop Freezing Field, provided she doesn't get a Black King Bar. He can either pop Spiked Carapace and simply walk into the field, or he can use Impale to interrupt the field, since Crystal Maiden has to channel it.
Additional:
* Spiked Carapace easily interrupts Freezing Field.
* 
Frostbite's damage over time sets up an easy Spiked Carapace stun.
* Crystal Maiden is extremely fragile and dies quickly to Nyx Assassin's burst damage.
Pudge
* Meat Hook brings Drow Ranger to Pudge, disabling Marksmanship and dealing a huge amount of damage when combined with Rot and Dismember.
* Rot keeps Pudge close to Drow Ranger, continuously disabling Marksmanship.
Additional:
* Meat Hook can pull Drow Ranger to Pudge, disabling her 
Marksmanship.
* Following up with Dismember will prevent Drow Ranger from using 
Gust or 
Shadow Blade.
Nyx Assassin
* Nyx Assassin has a lot of burst damage from his Impale, Mind Flare, 
Dagon, and the bonus damage from Vendetta. All of this damage is enough to kill Drow Ranger.
* Nyx Assassin is usually invisible most of the time thanks to his ability Vendetta, which allows him to gank Drow Ranger easily.
* However, Gust is extremely dangerous for Nyx Assassin, as it's silence can render Nyx Assassin unable to lock down Drow Ranger. And if Gust hits Nyx Assassin while he is invisible with Vendetta, Drow Ranger will be able to detect him and foil his ganking attempts on her because Gust reveals invisible units.
Pudge
* Rot and Meat Hook hits Dark Willow even when she uses Shadow Realm.
* Flesh Heap reduces Dark Willow's magic burst damage.
Nyx Assassin
* Nyx Assassin's high burst damage can be the bane of Dark Willow, as her low health makes it difficult to survive long enough to escape through Shadow Realm.
* Spiked Carapace can be triggered by walking deliberately into Bramble Maze, leaving Dark Willow stunned and defenseless.
Pudge
* Meat Hook can be used to pull Tinker to Pudge while he is hiding in the trees, and a follow up with Dismember and Rot can lead to a valuable kill, as Tinker doesn't buy many survivability items.
* Flesh Heap makes it hard for Tinker to deal serious damage.
Additional:
* Pudge can Meat Hook a Tinker hiding in the trees and follow it up with Dismember and Rot for an easy solo kill, as Tinker doesn't tend to buy survivability items.
* Many stacks of Flesh Heap combined with items that give Pudge high strength and health will make it hard for Tinker to deal serious damage to Pudge.
Nyx Assassin
* 
Heat-Seeking Missile allow easy Spiked Carapace stuns.
* As a fragile hero that relies on mana and intelligence items, Tinker is vulnerable to Mana Burn.
* Nyx Assassin's stuns can interrupt 
Rearm and leave Tinker helpless.
Additional:
* Nyx Assassin's whole skillset is good against Tinker:
* Impale prevents Tinker from blinding Nyx Assassin or fighting back, while giving Nyx' allies time to catch up to Tinker's position.
* Mind Flare generally deals more damage to intelligence based heroes like Tinker.
* Spiked Carapace can stun Tinker at a moment of Nyx Assassin's choosing if March of the Machines has been cast. It is also quite easy to time Spiked Carapace against Heat Seeking Missiles.
* Vendetta allows Nyx to approach Tinker in the trees or wait for him in common hiding spots and deal heavy damage to his low armor.
Pudge
* Axe, Bristleback, 
Centaur Warrunner, Spirit Breaker, Pudge, Huskar, 
Wraith King, Doom: These heroes are too tanky for Puck to burst down. Also, all of them have spells which can deal with and shut Puck down reliably.
Nyx Assassin
* 
Illusory Orb is easy to reflect with Spiked Carapace, either stunning Puck and setting up an easy Impale or forcing a premature 
Phase Shift.
* Puck is an intelligence hero that tends to build intelligence items, making it vulnerable to Mana Burn.
* An ill-timed Phase Shift can easily set Puck up to be stunned by Impale.
* Puck's low base armor and below average agility gain mean it is always susceptible to Vendetta.
Additional:
* Nyx Assassin can take advantage of every one of Puck's weaknesses. His entire skill set is very effective in countering Puck.
* Because Illusory Orb is such a slow moving projectile, Nyx Assassin can simply walk into the orb and activate Spiked Carapace, stunning Puck and setting up an easy Impale. This can be circumvented by using Phase Shift while the orb is traveling, however, that means that Puck cannot use Phase Shift to dodge any other skill nor use it to safely blink away from a fight.
* Puck is an intelligence hero that likes to build intelligence items such as 
Eul's Scepter of Divinity, 
Scythe of Vyse, and Dagon. This makes Mind Flare that much more deadly against Puck.
* An ill-timed Phase Shift can turn into an easy setup for Impale.
Pudge
* Heroes who build a Black King Bar (or have any sources of spell immunity) to channel abilities/items can still get interrupted by Dismember: Enigma, 
Juggernaut, Phantom Assassin, Pugna, 
Elder Titan.
Nyx Assassin
* 
Nether Blast's animation makes it easy to time Spiked Carapace for a stun.
* Pugna has the largest intelligence gain in the game, making him a prime target for Mana Burn.
* Pugna needs to channel Life Drain, making him easy to hit with Impale.
Additional:
* Due to Pugna's incredible intelligence growth and terrible strength growth, Nyx should always be able to take you out with his combo, with or without an added Dagon. Mind Flare will deal a large amount of damage in particular, especially in the late game.
* Spiked Carapace is also a great tool versus Pugna. A good player will wait for you in Vendetta until you farm a creep wave with Nether Blast and reflect it back at you as their initiation and setup for Impale.
Pudge
* Heroes with channeling spells because Shadow Fiend has nothing to cancel channeling outside of Requiem of Souls: Bane, Enigma, Pudge, Shadow Shaman, Dawnbreaker, Warlock, Crystal Maiden.
Nyx Assassin
* Large area-of-effect with delay or require channeling: Enigma, Crystal Maiden, 
Invoker, Shadow Fiend, Pugna, 
Keeper of the Light, Dawnbreaker.
Pudge
* Heroes that have a channeled ability that can be interrupted by Meat Hook: Shadow Shaman, Witch Doctor, Enigma, Bane.
Nyx Assassin
* Nyx Assassin, Bounty Hunter and Slark can all sneak up and kill Shadow Shaman, Nyx being particularly deadly. Shadow Shaman must watch out for Slark carefully, as he can break either (but not both unless he makes a mistake) of Shadow Shaman's disables, with Dark Pact and leap out of a serpent ward ring. These heroes, however, rely heavily on escape and are themselves not very durable and none of them can survive a full lockdown with Mass Serpent Ward. Having Sentry Wards can turn Shadow Shaman from prey to predator.
Nyx Assassin
* Nyx can walk into Firefly with Spiked Carapace and stun Batrider if he has no Spell Immunity, even if Batrider is focusing on other enemy hero.
Nyx Assassin
* Vendetta can deal great damage against her. However, it requires an direct attack, so Nyx Assassin may have difficulties applying Vendetta on her.
* Enchantress's lack of mobility makes her a primary target for ganking with Vendetta.
* Mind Flare can deal a great damage against her due to being an Intelligence hero.
* Spiked Carapace can reflect Impetus and stun Enchantress.
Additional:
* Spiked Carapace reflects the damage from 
Impetus.
* Enchantress is a rather squishy hero, making her fall easily to Nyx Assassin's high burst damage.
Pudge
* His Rot can force Templar Assassin out of her Meld and destroy all of her Refraction charges quickly, and her small health pool and meager defense make her very vulnerable to his Meat Hook without Refraction.
Nyx Assassin
* Nyx Assassin can simply activate Spiked Carapace while under many Invoker's abilities to stun him.
* Nyx Assassin takes advantage of Invoker's massive intelligence gain to do tons of damage using Mind Flare, as the spell does more damage based on the target's intelligence.
* Vendetta burns a large amount of Invoker's essential mana pool.
Nyx Assassin
* Nyx's Spiked Carapace can reflect the damage of 
Sharpshooter, instantly killing hoodwink. Nyx can also use Vendetta to position himself in such a way to screen allies from Sharpshooter and catch Hoodwink by surprise.
Pudge
* Zeus likes to stay far back in fights, dealing his damage uninterrupted, but once he gets hooked into the fight, he usually dies very quickly.
* Pudge's high strength from Flesh Heap makes it very hard for Zeus to burst him down.
* Zeus' low health pool makes him very vulnerable to the damage from Meat Hook, Rot and Dismember.
Additional:
* Meat Hook's high range allows Pudge's team to drag Zeus in the middle of the fight and abuse his frailty.
* Flesh Heap's health and magic resistance bonus makes Pudge exceptionally resistant to Zeus' nukes. In later stages of the game, Zeus is usually unable to seriously damage Pudge at all. Even Static Field, which deals damage based on a percentage of the enemy's health, won't be doing much.
* Even if Zeus buys a Black King Bar, Meat Hook and Dismember still disable him for a long time, usually causing Zeus' quick death.
* Zeus is vulnerable to early ganks, which Pudge excels at.
Pudge
* Pudge's Dismember stops Spectre from escaping with 
Haunt.
* He can easily tank the damage reflected by 
Dispersion due to his high strength and the healing from Dismember.
* Should Spectre try to get away through the trees or over a cliff with 
Spectral Dagger, Pudge can hook her back.
* Spectre takes a long time to become powerful, and Pudge can ruin her early game with ganks.
Nyx Assassin
* Spiked Carapace can be used to reflect Illuminate damage and stun Keeper of the Light.
* Vendetta allows Nyx Assassin to follow Keeper of the Light around if he tries to split-push.
* Keeper of the Light is very squishy and will very quickly die to Vendetta and it's followup abilities.
Nyx Assassin
* Mana Burn removes much-needed mana for 
Ball Lightning.
* Spiked Carapace triggers on 
Static Remnant for an easy stun.
Additional:
* Vendetta is capable of removing most of Storm Spirit's large mana pool, along with dealing heavy damage and quickly depleting his chances of escaping a gank or fight.
Pudge
* Heroes with a high degree of mobility and invisibility are hard to catch with Meat Hook: Ember Spirit, Riki, Clinkz, Queen of Pain.
Pudge
* Heroes who recklessly jump on Pudge with their gap-closing abilities will be easy targets for Pudge's Meat Hook and Dismember Combo: Phantom Assassin, Faceless Void, Queen of Pain etc.
Nyx Assassin
* A good Nyx can reflect Queen of Pain's Sonic Wave with his Spiked Carapace, or even initiate a gank on her in Vendetta while she farms a creep wave with Scream of Pain.
* Her strength to intelligence ratio is bad enough that he should be able to kill her without even requiring a Dagon, provided he can get his full combo off.
Nyx Assassin
* 
Last Word is extremely easy to reflect with Spiked Carapace for large amounts damage, due to triggering when Nyx Assassin casts a spell, but can still silence Nyx Assassin. It also has the added bonus of dealing more damage the more Intelligence Silencer has.
* 
Glaives of Wisdom quickly builds Silencer's Intelligence, making him a particularly prime target for Mana Burn.
* Silencer rarely builds survivability items, nor is he able to steal much Intelligence while surrounded by his team, and so is an excellent target for Vendetta.
* Silencer has no reliable way of dealing with a burrowed Nyx, and also lacks the ability to prevent Nyx from escaping with Vendetta,
Additional:
* Silencer is rather squishy and has poor mobility without items, making him an easy target for Nyx.
* Silencer's intelligence steal ability is a complete disadvantage against Nyx Assassin as Mind Flare will deal increasing damage for each point of intelligence Silencer has stolen, turning Silencer's intelligence steal against him.
Nyx Assassin
* Nyx Assassin's Spiked Carapace will stun Leshrac when hit by any of his AOE abilities.
* Mind Flare deals high damage due to Leshrac's high intelligence gain.
* Vendetta burns a large amount of Leshrac's essential mana pool.
Nyx Assassin
* Impale and Spiked Carapace interrupts Upheaval with ease.
* Warlock's low health pool, mobility, and high intelligence gain makes him a prime target for Nyx Assassin's burst damage.
Pudge
* Even with Black King Bar, Pudge's Meat Hook and Dismember can still catch and disable Bane while he is channeling Fiend's Grip, breaking the channel as a result, Meat Hook can also be used to save targets affected by Bane's abilities.
* Dismember can disable Bane while channeling Fiend's Grip if Pudge is not targeted. Aghanim's Shard upgraded Dismember can also be used to save an allied hero that is targeted by Fiend's Grip.
* Pudge's high health and health regeneration allows him to survive through most of Bane's abilities.
Nyx Assassin
* Heroes who build Black King Bar as either core or situational item will be able to fight back against Nyx Assassin and freely attack him as Spiked Carapace cannot pierce spell immunity at all: Axe, Broodmother, Dawnbreaker, Enigma, Huskar, Jakiro, Legion Commander, Lina, Luna, Lycan, Slardar, Slark, Troll Warlord, Witch Doctor.
Pudge
* Even with Black King Bar, Pudge's Meat Hook and Dismember can still disable Engima while he is channeling Black Hole as Enigma is a very easy target while channeling Black Hole.
* Pudge's Aghanim's Shard upgraded Dismember and Meat Hook are great ways to save allies from Black Hole.
* Enigma is prone to ganks in the jungle or in the off-lane without proper vision. Pudge can take advantage of Enigma's lack of mobility, and gank him often.
Nyx Assassin
* Enigma is fragile, and lacks escapes, being dependent on Blink Dagger for mobility. Ganking Heroes or Heroes with burst damage will likely kill him before he can do anything. Such Heroes include: Lina, Lion, Luna, 
Puck, Slark, Nyx Assassin, etc.
Additional:
* Enigma's uncontrollable damage from 
Malefice and 
Midnight Pulse make him easy to stun with Spiked Carapace.
* Black Hole can be easily interrupted by Impale or Spiked Carapace.
Nyx Assassin
* Vendetta disables Vengeance Aura and allows him to attack Vengeful Spirit with Impale and Mind Flare.
* Spiked Carapace is easy to use against a Wave of Terror or Magic Missile.
Nyx Assassin
* Vendetta burns a significant amount of mana on hit, and the damage from the ability drains Medusa's mana pool even further.
* Due to the passive nature of Mystic Snake and Split Shot, it can possibly proc Nyx's Spiked Carapace if he's within range of Medusa's abilities and isn't invisible.
* Medusa lacks single target damage, making Nyx with Aghanim's Scepter extremely hard to deal with if Medusa is the team's main damage source.
Additional:
* With her passive 
Split Shot, Medusa can be easily interrupted by Spiked Carapace during combat, especially during her precious 
Stone Gaze.
* Mana Burn quickly destroys 
Mana Shield, especially if Medusa only increases her mana pool by bolstering intelligence (which has the added bonus of increasing Mana Burn's damage).
* Uncontrollable damage from 
Mystic Snake and Split Shot can trigger Spiked Carapace.
* 
Medusa lacks single target damage, making a Burrowed Nyx Assassin hard to kill.
Pudge
* Pudge has low armor and low mobility, making him a prime target for Terrorblade's right-clicks.
* Meat Hook is a lot harder to land on the real Terrorblade if he has illusions around him.
* Because Dismember targets only one hero, Terrorblade's illusions can potentially save the real Terrorblade if he's caught in it.
Pudge
* Heroes who have channeling abilities because Terrorblade has no disables to cancel them at all besides 
Terror Wave from Aghanim's Scepter, and he does not like buying disabling items at all: Enigma's Black Hole, Witch Doctor's Death Ward, Shadow Shaman's Shackles, Lion's Mana Drain, Bane's Fiend's Grip, Pudge's Dismember, Crystal Maiden's Freezing Field, Pugna's Life Drain, Dawnbreaker's Solar Guardian, and Naga Siren's Reel In from Aghanim's Scepter.
Nyx Assassin
* Nyx Assassin deals large amounts of pure damage with Vendetta and magical damage with Impale and Mind Flare, allowing him to ignore Terrorblade's armor and burst his low health pool down before he can use 
Sunder.
* Nyx Assassin commonly buys 
Urn of Shadows, Dagon and 
Meteor Hammer which deal magic damage that ignore Terrorblade's armor.
* However, Terrorblade is a natural Eye of Skadi and Black King Bar wielder, and once he gets those items, Nyx Assassin's solo kill potential against Terrorblade will be gone.
Pudge
* Heroes with other kind of disables that pierce spell immunity can hold Pangolier in place during Rolling Thunder: Axe, 
Beastmaster, Enigma, Magnus, Pudge, 
Batrider, Bane, 
Winter Wyvern
Pudge
* Abilities that deal low damage with high amounts of instances are irrelevant against Pudge during Flesh Heap's active: 
Gyrocopter's 
Rocket Barrage and Dark Seer's 
Ion Shell are just a couple examples.
Nyx Assassin
* Like above, supports with reliable stuns can be a massive problem and force Black King Bar in fights unideally, such as Shadow Shaman, Lion, Nyx Assassin.
Pudge
* Heroes that can cancel Charge of Darkness: 
Ogre Magi, 
Earthshaker, Lion, 
Rubick, Lina, Luna, Jakiro, Dawnbreaker, 
Alchemist, Ogre Magi, Axe, Shadow Shaman, Naga Siren, 
Mars, Bane, Pudge, Clockwerk.
Nyx Assassin
* Heroes with silence and mana drain abilites, as Ancient Apparition relies entirely on his abilities: Invoker, 
Silencer, Nyx Assassin, Skywrath Mage, Shadow Shaman, Lion and etc.
Nyx Assassin
* Heroes that can pick you off: Clinkz, Nyx Assassin, Puck, Riki.
Pudge
* Generally heroes who don't rely on magical damage, such as Sven, Phantom Assassin, and Outworld Destroyer, as they can practically ignore Flesh Heap's damage block.
Pudge
* Heroes with disables that ignore spell immunity will render Phantom Assassin completely useless in teamfights throughout the game: Axe, Enigma, 
Vengeful Spirit, Doom, Bane, Beastmaster, Pudge, Medusa, Warlock.
Additional:
* If Phantom Assassin jumps on Pudge first with 
Phantom Strike, she will be a very easy target for Pudge's Meat Hook and Dismember combo.
* Even though it can deal damage based on Pudge's max health, 
Fan of Knives from Aghanim's Shard cannot disable Pudge's Flesh Heap as Flesh Heap is one of the few passive abilities that cannot be disabled by break.
* Both Meat Hook and Dismember ignore spell immunity which allows Pudge to disable Phantom Assassin even while she has Black King Bar active.
* Pudge occassionally buys armor items like Blade Mail, which in combination with many stacks from Flesh Heap can make Phantom Assassin have little effect against Pudge.
Nyx Assassin
* Heroes with heavy early and mid-game magical damage are also problematic for Phantom Assassin due to being able to easily kill her before she can gain an item advantage over them: Lina, Necrophos, Nyx Assassin, Gyrocopter, Jakiro, 
Death Prophet.
Nyx Assassin
* Slow-moving projectiles: Skywrath Mage, Tinker, Necrophos
Additional:
* Skywrath Mage's low health makes him rather easy prey for Nyx Assassin and his lack of armor generally means he'll take the full brunt of a Vendetta strike.
* Mind Flare turns Skywrath Mage's high intelligence growth against him and deals heavy damage.
* Spiked Carapace gives Nyx some degree of protection against Skywrath's spells.
Pudge
* Because only one clone needs to be killed in order to kill Meepo, heroes that excel at singling out enemies can also be a detriment to him, such as Batrider, Beastmaster, Pudge and Clockwerk.
Nyx Assassin
* Heroes who can drain mana can make Omniknight useless after he uses one or two abilities: Lion, Anti-Mage, Nyx Assassin.
Nyx Assassin
* Heroes who rely on invisibility, such as Bounty Hunter, Clinkz, Mirana, Nyx Assassin and Riki, as they will be revealed if caught by Chronosphere.
Pudge
* Meat Hook can pull an ally out of Chronosphere.
* Rot will keep damaging Void if he toggled it before Chronosphere, but you can lower your hp for Faceless Void.
* Flesh Heap will help Pudge survive through the Chronosphere with enough stacks, and follow with Dismember.
Nyx Assassin
* Heroes who rely on damage over time as Spiked Carapace can block and reflect only one instance of damage: Jakiro, Viper, Venomancer, Huskar, Ember Spirit, Dark Seer, Sand King, Doom, Dawnbreaker. However, this also means they are easily stunned.
Nyx Assassin
* Spiked Carapace can stop Dawnbreaker's Solar Guardian which will eliminate her global presence and limits her movement around the map.
Additional:
* Spiked Carapace interrupts 
Starbreaker before Dawnbreaker has her Aghanim's Shard, as well as Solar Guardian during the initial channel, making her ineffective at joining and dealing damage in teamfights.
* The slow projectile and damage over time effect of 
Celestial Hammer makes it easy to stun Dawnbreaker if she attemps to engage or chase.
Pudge
* Heroes with high health especially Strength heroes will take more damage on Sun Ray: Axe, Pudge, Bristleback, Mars.
Nyx Assassin
* Spiked Carapace reacts on any of the damage over time from Phoenix's abilities and can interrupt 
Sun Ray and 
Icarus Dive.
Pudge
* Rot is not very effective against Chen's creeps.
* Chen can use his creeps to cover him or his allies from any attempts of Meat Hook.
* {U:Centaur Conqueror} or {U:Mud Golem} under Chen's control can interrupt Dismember.
Pudge
* Heroes with channeling spells, for Chen has no disables on his own, hates buying disabling items and his creeps are often not fast enough to cancel them: Enigma's Black Hole, Witch Doctor's Death Ward, Shadow Shaman's Shackles, Lion's Mana Drain, Bane's Fiend's Grip, Pudge's Dismember, Crystal Maiden's Freezing Field, Pugna's Life Drain, Dawnbreaker's Solar Guardian, and Naga Siren's Reel In from Aghanim's Scepter.
Nyx Assassin
* Heroes with either magical, physical or pure damage burst can often kill Chen or his allies before he can use Hand of God: Lina, Luna, Techies, Shadow Fiend, Pugna, Nyx Assassin.
Pudge
* Heroes with many summons or illusions are much harder to catch with Meat Hook: Nature's Prophet, Phantom Lancer, 
Chen.
Nyx Assassin
* Heroes with invisibility: (Riki, Clinkz, Nyx Assassin.
Nyx Assassin
* Heroes who rely on damage over time as Spiked Carapace can block and reflect only one instance of damage: Jakiro, Viper, Venomancer, Huskar, Ember Spirit, Dark Seer, Sand King, Doom, Dawnbreaker. However, this also means they are easily stunned.
Nyx Assassin
* Nyx Assassin can reflect Life Break with Spiked Carapace.
Pudge
* No matter how high Pudge builds up strength with his Flesh Heap, all it needs is for him to fall below a certain percentage of health for him to fall to Reaper's Scythe. Considering his constant self-damage with Rot, being around Heartstopper Aura will prove risky for an overconfident Pudge.
Additional:
* 
Heartstopper Aura is effective against high health heroes, and Pudge is no exception. Coupled with his self-damage from Rot, being around Heartstopper Aura could prove risky for Pudge.
* Regardless of how much health Pudge gains through Flesh Heap, 
Reaper's Scythe will often kill Pudge should his health fall below 40%, making Necrophos an ideal counter versus Pudge.
Nyx Assassin
* The huge physical damage taken from Vendetta will force Necrophos to use Ghost Shroud, which is good for a followup with Dagon and 
Ethereal Blade, both of which are common items on Nyx Assassin.
* Using Ghost Shroud also sets Necrophos up for a Mind Flare or Impale.
Pudge
* 
Kraken Shell can dispel Dismember after reaching a certain threshold of damage.
* Tidehunter's naturally high health, strength gain, and common itemization for survivability through magic resistance makes Tidehunter a poor target.
Nyx Assassin
* Ravage's travel time allows Nyx Assassin to easily stun Tidehunter with Spiked Carapace.
* Vendetta can instantly deplete Tidehunter's low mana pool, especially in the early game, potentially preventing Tidehunter from casting Ravage.
Nyx Assassin
* Heroes who build Black King Bar as either core or situational item will be able to fight back against Nyx Assassin and freely attack him as Spiked Carapace cannot pierce spell immunity at all: Axe, Broodmother, Dawnbreaker, Enigma, Huskar, Jakiro, Legion Commander, Lina, Luna, Lycan, Slardar, Slark, Troll Warlord, Witch Doctor.
Pudge
* Heroes that have a channeled ability that can be interrupted by Meat Hook: Shadow Shaman, Witch Doctor, Enigma, Bane.
Additional:
* Meat Hook interrupts Death Ward from a decent range, even through Black King Bar & Glimmer Cape.
* Pudge can survive the damage from Maledict because of his Flesh Heap stacks.
* However the damage-over-time from Rot is counteracted by Voodoo Restoration.
Nyx Assassin
* Blade Fury makes Juggernaut immune to all Nyx's abilities, except Vendetta.
* Omnislash. and Swiftslash can burst Nyx down, ignoring Spiked Carapace. However, Vendetta can be used to escape, canceling Omnislash/Swiftslash.
Additional:
* Juggernaut's entire skillset greatly counters Nyx Assassin's Spiked Carapace, his most important ability.
* Blade Fury allows Juggernaut to freely attack Nyx Assassin, and deal heavy damage to Nyx Assassin. Nyx Assassin cannot counter Blade Fury with Spiked Carapace because Blade Fury gives Juggernaut spell immunity. And besides Vendetta, Nyx Assassin has no other way of dealing damage to Juggernaut while he is spell immune.
* 
Healing Ward allows Juggernaut to recover himself and his allies from Nyx Assassin's damage output.
* Omnislash and Swiftslash from Aghanim's Scepter can quickly finish off Nyx Assassin. And just like Blade Fury, Nyx Assassin cannot counter neither Omnislash and Swiftslash from Aghanim's Scepter with Spiked Carapace because both abilities render Juggernaut invulnerable. And if Nyx Assassin has no Vendetta available to use for escaping, both abilities will kill him very quickly before he can do anything.
* Overall, any attempt for Nyx Assassin to gank and kill Juggernaut will hurt Nyx Assassin more than Juggernaut.
Pudge
* Meat Hook can hit and displace Juggernaut during his Blade Fury.
* Dismember pierces Juggernaut's spell immunity from Blade Fury.
Pudge
* 
Shukuchi grants Weaver invisibility and a high degree of mobility for a short time, which can make him a difficult target to hook.
* 
The Swarm beetles are difficult for Pudge to remove, due to his low base attack time and poor agility. Additionally, it can be used to can scout out Pudge's location.
* Should an ally get snagged by Meat Hook, Weaver can use Aghanim's Scepter upgraded 
Time Lapse on them to send them back to where they were before hooked, even if Pudge has already started to Dismember them.
Additional:
* While Weaver is in Shukuchi, Rot doesn't slow him and Meat Hook is easy to avoid.
* Even when hooked, Weaver can use Time Lapse, negating both the damage and displacement.
* Pudge has low armor and low attack speed, making him susceptible to The Swarm and physical attacks.
* Dismember is easy to block with Linken's Sphere and it's the only way to break Weaver's Linken Sphere.
* However, the long duration stun of Dismember can be dangerous for Weaver.
Nyx Assassin
* Spiked Carapace allows Nyx to get an easy long-duration stun on Weaver once he uses Shukuchi, and then he can follow up with Impale.
* Vendetta works as a great setup for both Impale and Spiked Carapace and can deal decent damage to Weaver. Additionally he can neutralize The Swarm beetles due to his invisibility duration.
Pudge
* Pudge relies on his hook to initiate his combo. As long as she's able to avoid the hook with Windrun and shackle him, Windranger can take him down easily. Pudge's low armor means that he won't be able to endure Focus Fire for long.
Nyx Assassin
* Many of Nyx Assassin's abilities are good against Windranger.
* Impale is great for stunning Windranger and allowing additional disables to be landed.
* Mind Flare is useful against Windranger's decent intelligence growth.
* Spiked Carapace is easy to use against Powershot.
* Vendetta allows Nyx Assassin to sneak up on and deal massive damage to Windranger without giving Windranger a chance to use Windrun to evade it.
* Nyx Assassin's item build allows him to easily deal with Windranger.
Pudge
* Pudge has low armor and mobility, making him suspectible to her physical attacks (if Lina is the carry).
* Because Dismember is a channeled ability, it can be canceled through Light Strike Array within a distance.
Nyx Assassin
* Heroes who build Black King Bar as either core or situational item will be able to fight back against Nyx Assassin and freely attack him as Spiked Carapace cannot pierce spell immunity at all: Axe, Broodmother, Dawnbreaker, Enigma, Huskar, Jakiro, Legion Commander, Lina, Luna, Lycan, Slardar, Slark, Troll Warlord, Witch Doctor.
Pudge
* Heroes with abilities that can pull Lina out of position can easily bring her to their team mates, like Batrider with 
Flaming Lasso, Pudge with Meat Hook and Vengeful Spirit with 
Nether Swap.
Nyx Assassin
* Mind Flare does tons of damage against Lina because of her high intelligence.
* Vendetta can deal heavy damage to Lina while also burning her mana, preventing Lina from casting her abilities.
* Spiked Carapace can easily be used to counter Lina's abilities because of their long cast animation, and could probably kill Lina outright if Laguna Blade is reflected. However, Lina can counter this with Eul's Scepter of Divinity, a common item on Lina.
Pudge
* 
Sanity's Eclipse deals more damage the less max mana the heroes hit by it have, making Pudge an ideal target.
* Outworld Destroyer can save allies or himself caught by Dismember or Meat Hook with 
Astral Imprisonment.
Nyx Assassin
* Outworld Destroyer's high intelligence gain and fragility makes him an easy target for a massive Mana Burn, as well as killing him outwards with Nyx Assassin's high burst damage.
* Astral Imprisonment can be easily exploited by Nyx Assassin with his abilities. As long as Astral Imprisonment was not cast on Nyx Assassin, it will make an opportunity for an easy stun, either by Spiked Carapace (if Outworld Destroyer hid his allies or your allies) or Impale (if he hid himself). If Astral Imprisonment was cast on Nyx Assassin, using Spiked Carapace while banished will proc the stun after the disable, since Spike Carapace has a 0 second cast time and Astral Imprisonment deals damage right after the disable ends.
* An ill-timed Sanity's Eclipse and/or well timed Spiked Carapace can deal a lot of damage to Outworld Destroyer and stun him, unless Outworld Destroyer used Black King Bar beforehand.
Additional:
* Outworld Destroyer's high intelligence makes him a good target for Mind Flare.
* If timed correctly, Spiked Carapace will return the full damage from Sanity's Eclipse back to Outworld Destroyer. Even a reflected Arcane Orb can deal significant damage and make him vulnerable to a follow-up from Nyx Assassin.
* Spiked Carapace is also the perfect tool against Astral Imprisonment: if used on Nyx, he can reflect the damage back as he comes out of the prison by casting the ability while imprisoned.
Nyx Assassin
* Heroes who rely on damage over time as Spiked Carapace can block and reflect only one instance of damage: Jakiro, Viper, Venomancer, Huskar, Ember Spirit, Dark Seer, Sand King, Doom, Dawnbreaker. However, this also means they are easily stunned.
Pudge
* Abilities that deal low damage with high amounts of instances are irrelevant against Pudge during Flesh Heap's active: Gyrocopter's Rocket Barrage and Dark Seer's Ion Shell are just a couple examples.
Pudge
* Slow heroes that have a hard time escaping the Echo Stomp radius: Crystal Maiden, Pudge, Techies.
Pudge
* Heroes who build a Black King Bar (or have any sources of spell immunity) to channel abilities/items can still get interrupted by Dismember: Enigma, Juggernaut, Phantom Assassin, Pugna, Elder Titan.
Nyx Assassin
* Heroes who are entirely reliant on dealing physical damage and/or have very little to no area-of-effect abilities will make Underlord tickle and will have no effect against him thanks to his 
Atrophy Aura, and will also be unable to ambush Underlord and his team if Underlord chooses to use 
Fiend's Gate to get to a designated point of the map: Phantom Assassin, 
Terrorblade, Troll Warlord, 
Drow Ranger, Phantom Lancer, 
Chaos Knight, Sven, Wraith King, Bounty Hunter, Alchemist, Templar Assassin, Nyx Assassin, Bane.
Nyx Assassin
* Heroes with magical or pure damage output will not have any problems against Atrophy Aura at all: Luna, Lina, Jakiro, Pugna, Bane, 
Snapfire, 
Muerta, Nyx Assassin, Enigma, Tinker, Witch Doctor, 
Zeus, Crystal Maiden.
Pudge
* Pudge has a very hard time killing Familiars due to his melee range and low attack speed.
Dismember.
* Stone Form can quickly interrupt
Nyx Assassin
* Even though Visage's Familiars from
Summon Familiars are fragile and can be killed quickly with Nyx Assassin's high burst damage, they can deal many instances of damage quickly, minimizing the effectiveness of Spiked Carapace.
Gravekeeper's Cloak and tanky item builds make Visage hard for Nyx to kill with his burst damage. 
Aghanim's Shard upgraded 
Gravekeeper's Cloak also allows Visage to use 
Stone Form to both recover himself and stun Nyx Assassin if he is close enough to Visage.
Soul Assumption and 
Grave Chill make him hard to escape from, and 
Soul Assumption's low cooldown outmatches Spiked Carapace.
*
* Visage's long range on