* Ghostship helps your team soak up damage from Sonic Wave and Scream of Pain.
* Queen of Pain can't escape easily from X Marks the Spot - Torrent combo.
* Outlanes Queen of Pain on the midline, due to the fact that Queen of Pain has a small reserve of health at the beginning of the game, and she suffers very much from Tidebringer, which is why she is forced to either spend money on Tango, or skip creeps and run for bounty runes, and Kunkka at this time will gain an advantage in level and gold.
Additional:
* Outlanes Queen of Pain on the midline, due to the fact that Queen of Pain has a small reserve of health at the beginning of the game, and she suffers very much from Tidebringer, which is why she is forced to either spend money on Tango, or skip creeps and run for bounty runes, and Kunkka at this time will gain an advantage in level and gold.
* Kunkka will catch her in X Marks the Spot and allow his team to kill her for stun from Torrent, because Queen of Pain has no way to avoid the cross X Marks the Spot before buying Black King Bar.

* Tidebringer will deal lots of damage to Alchemist before he builds physical survivability items.
* Torrent and X Marks the Spot can control Alchemist at all stages of the game before he has Black King Bar.
* Ghostship's rum buff will greatly reduce the Alchemist's damage output in teamfights including his Radiance.

* A good Skywrath Mage with quick fingers will punish Queen of Pain for blinking aggressively. Ancient Seal is a six second silence with no cast time, so he can interrupt either her Shadow Strike or Sonic Wave, and a good Mystic Flare on top of that will seal the deal for her.
* Ancient Seal also has pretty good range so he could get it off before she blinks away.

* Skywrath Mage can easily harass Alchemist in the laning phase with multiple Arcane Bolts. Additionally, if Alchemist is in the process of throwing an Unstable Concoction, and has no way to dispel Ancient Seal, the self stun becomes an easy set up for Mystic Flare.
* Caution, however, as a decently farmed Alchemist with {Item ID:Radiance} and {Item ID:Manta Style} can easily send illusions to harass and force Skywrath Mage out.

* Aggressively blinking is not going to end well against Luna, because Queen of Pain will be an easy target for Lucent Beam & Eclipse.
* Queen of Pain's HP is abysmal, so Luna can quickly kill Queen of Pain as soon as she initiates with Blink.
Additional:
* Aggressively blinking is not going to end well against Luna, because Queen of Pain will be an easy target for Lucent Beam & Eclipse.
* Queen of Pain's HP is abysmal, so Luna can quickly kill Queen of Pain as soon as she initiates with Blink.

* Heroes who are melee but cannot fight back against Eclipse will really struggle with Luna: Monkey King, Alchemist, Timbersaw.

* Heroes that have escape abilities (such as Queen of Pain, Storm Spirit or Timbersaw) can be either nullified by Reaper's Scythe or a complimentary item for Necrophos (like Rod of Atos or Scythe of Vyse). If Necrophos is quick enough and enters range, they can quickly, if not instantly, die if they are not quick enough.

* Reaper's Scythe can kill Alchemist before Chemical Rage has the time to heal him.
* Ghost Shroud can prevent Alchemist from attacking Necrophos, as well as make him immune to Acid Spray and Unstable Concoction damage.
* Heartstopper Aura will do damage as long as Necrophos is alive based on health percentage, which is a problem for a strength hero such as Alchemist.

* Heroes with gap-closing abilities will be easy targets for Berserker's Call: Phantom Assassin, Faceless Void, Slark, Chaos Knight, Morphling, Queen of Pain

Additional:
* Berserker's Call prevents Queen of Pain from escaping with Blink and also pierces her Black King Bar.
* Due to her fast attack speed from Mjollnir, it will quickly trigger Counter Helix.
* Culling Blade finishes off Queen of Pain's low health pool before she gets a chance to escape, preventing her from playing the hit-and-run style often associated with Queen of Pain.

* Axe can force Alchemist to attack him with Berserker's Call. High attack speed from Chemical Rage will cause Counter Helix to proc multiple times.
* This can get worse if axe has Blade Mail, which then returns all damage to Alchemist himself.
* Axe's abilities can pierce through Black King Bar, which is a common item for Alchemist.
* Berserker's Call grants Axe a huge bonus armor, which greatly counters Alchemist's physical damage for the most part.

* Meepo is the hard counter for Queen of Pain - chaining Earthbinds prevents her from using Blink for a long time, and without any other escape options, Queen of Pain cannot survive several Poofs and attacks.
* Meepo tends to build items with attributes, mitigating Queen of Pain's magical burst.
Additional:
* Chain of Earthbinds prevents her from using Blink, allowing Meepo to quickly kill her with Poof and attacks.
* Meepo tends to buy items with attributes, mitigating Queen of Pain's magical burst.

* Alchemist likes to farm fast and be ahead, unfortunately Lone Druid likes to do the same by taking towers.
* Acid Spray will never prove a threat to Lone Druid or his Spirit Bear.
* Chemical Rage may not prove so useful once Lone Druid procs entangled keeping him in place.
* Monkey King Bar is a very good choice on Lone Druid's Spirit Bear and it directly counters any potential Radiance from Alchemist.
* Assault Cuirass is another very good Spirit Bear item that further makes Alchemist vulnerable to physical damage, which is all Lone Druid does.
* Alchemist is not the kind of hero who wants to go on single target summon units, by the time he has killed the Spirit Bear his teammates might had already been slayed by his teammates. Not to mention Lone Druid can just resummon it, even if he is successful.

* Corrosive Haze followed by Slithereen Crush takes advantage of Alchemist's main weakness, being physical damage before he has the change to improve his surviability with items.
* Bash of the Deep will deal lots of damage during the laning phase.

* Sonic Wave is a bad choice in abilities if he and the Tempest Double both use Blade Mail to reflect the damage to Queen of Pain, potentially killing her outright if her health is low enough.
* Magnetic Field protects himself or his ally from Queen of Pain's attacks unless she has Monkey King Bar.
* One more advantage of Tempest Double is that he can deny himself if he is close to death with Shadow Strike's debuff.

* Smoke Cloud prevents Queen of Pain from using any of her offensive and defensive spells, rendering her unable to effectively react to Riki's attack.
* It's easy to dodge Sonic Wave by using Blink Strike & Tricks of the Trade.

* Because Queen of Pain's spells cost a decent amount of mana, Anti-Mage can easily use Mana Void if she spams her spells recklessly.
* Anti-Mage has similar mobility through Blink, which can allow him to catch up with her.
* Counterspell will reduce the damage done by Shadow Strike and Scream of Pain. Additionaly, Counterspell also reflect to Shadow Strike will return to herself.

* Night Stalker has a huge, almost instant silence through Crippling Fear. The main problem is that he can get it off while Queen of Pain barely has any vision of him if he creeps up to her during Dark Ascension. She'll have to play very carefully before she gets a Black King Bar or a Eul's Scepter of Divinity.

* A good Nyx can reflect Queen of Pain's Sonic Wave with his Spiked Carapace, or even initiate a gank on her in Vendetta while she farms a creep wave with Scream of Pain.
* Her strength to intelligence ratio is bad enough that he should be able to kill her without even requiring a Dagon, provided he can get his full combo off.

* Feast is good against high health strength heroes such as Alchemist.
* Rage allows Lifestealer to not be targetable by Unstable Concoction, possibly making Alchemist stun himself.

* A good Centaur can catch Queen of Pain with a Blink Dagger and Hoof Stomp.
* Retaliate with Blade Mail reflects all of Queen of Pain's damage, especially Sonic Wave.
* Stampede grants a movement speed bonus, which can prevent Queen of Pain from initiating.
* Double Edge can shred her low health pool if she's not careful.

* Time Walk and Backtrack allows Faceless Void to easily negate Queen of Pain's burst damage.
* Chronosphere prevents Queen of Pain from escaping with Blink, and her low survivability makes her an easy kill.
* Time Dilation will prevent Queen of Pain from using her low-cooldown spells or force her to buy Black King Bar or a Eul's Scepter of Divinity to dispel the debuff and re-engage.
Additional:
* Time Dilation affects Queen of Pain's low cooldown abilities, making them unusable for a long time, rendering Queen of Pain nearly useless.
* Chronosphere provides excellent lockdown against Queen of Pain, allowing for reliable kills in all stages of the game.

* Queen of Pain's intelligence is very vulnearble stealing after Silencer kill her with Glaives of Wisdom and influence mana regen and mana pool from her.

* Lina has a very long range of attack, which completely overlaps the range of Queen of Pain's abilities and attacks, which is why even a single Shadow Strike roll can become deplorable, since Lina will shoot Queen of Pain from a long distance before and after the Shadow Strike roll. And with the help of the abilities of Light Strike Array and Laguna Blade, Lina can even kill Queen of Pain because of her small health reserve if she is exposed to a blow
Additional:
* Lina has a very long range of attack, which completely overlaps the range of Queen of Pain's abilities and attacks, which is why even a single Shadow Strike roll can become deplorable, since Lina will shoot Queen of Pain from a long distance before and after the Shadow Strike roll. And with the help of the abilities of Light Strike Array and Laguna Blade, Lina can even kill Queen of Pain because of her small health reserve if she is exposed to a blow

* Blood Rite prevents Queen of Pain from escaping with Blink.
* Blink will trigger the extra damage from Rupture.
Additional:
* Blood Rite silences her, preventing her from initiating or escaping.
* With Thirst, even if she Blinks away, Bloodseeker can catch right up to her.
* Rupture will heavily damage Queen of Pain if she tries to Blink away.
* She is, however, one of the few heroes who can avoid the damage from Rupture if she successfully blink-walks.

* Duels prevents Queen of Pain from using Blink, which may force her to purchase a Linken's Sphere
* Because Queen of Pain is also not a right-click hero, Legion won't have much difficulties in duels.
* Press the Attack dispels Shadow Strike's debuff.

* Silence will prevent Queen of Pain from using Blink to escape or chase.
* If Queen of Pain uses Blink to close the gap to Death Prophet, Death Prophet will be in range for Spirit Siphon and typically gain an advantage over Queen of Pain.

* Thunder Strike gives vision of Queen of Pain when she's trying to escape. When combined with Glimpse, her mobility and hit-and-run style can be negated.
* While in a team fight, Static Storm forces Queen of Pain to only use right-clicks.
* When combined with the Kinetic Field, she can only wait until she respawns.
Additional:
* Blink and positioning is crucial for Queen of Pain. These factors are heavily countered by a good Glimpse.
* Static Storm is devastating for Queen as she relies heavily on her spells to inflict heavy burst damage.

* All her abilities can stealing by Rubick with Spell Steal.
* Rubick's always purchase Blink Dagger can catch up Queen of Pain's and since Rubick's get stealing Blink, Rubick's makes escape twice blink or since Rubick's get Aghanim's Shard,Rubick's Telekinesis can save him although Blink and Blink Dagger cooldown.

* Clinkz can use Burning Army in teamfights which will cause a problem for Alchemist.

* In general, squishy heroes that rely on escape often struggle against the amount of disables Shadow Shaman can bring. Queen of Pain, Anti-Mage and Storm Spirit are among these.

Additional:
* Shadow Shaman has many disables to lock down Queen of Pain, preventing her from Blinking away, even through Linken's Sphere or her spell block talent.
* Mass Serpent Ward can tear through Queen of Pain's low health pool once she's locked down by Hex & Shackles.

* Pugna's Decrepify makes sure that either Alchemist is unable to hit anyone while also being slowed and susceptible to magical damage, or can protect an ally from physical attacks. Besides, Pugna can push early on, when Alchemist is not strong enough to repel it, so by the time Alchemist comes online, he might be forced to sit in base.

* Heroes that depend on disrupting fights with ability combos or big ultimate abilities are vulnerable to the long stun of Fiend's Grip: Disruptor, Death Prophet, Enigma, Faceless Void, Invoker, Lich, Magnus, Mars, Medusa, Outworld Destroyer, Phoenix, Puck, Queen of Pain, Shadow Fiend, Treant Protector, Underlord, Winter Wyvern, Witch Doctor, Zeus.

* Melee heroes with low mobility can be kited and killed by Viper: Treant Protector, Kunkka, Alchemist, Troll Warlord, Wraith King, Tiny, Sven.

* Heroes who rely on physical damage output to be effective will fare badly against Muerta's Pierce the Veil: Phantom Assassin, Terrorblade, Drow Ranger, Lifestealer, Anti-Mage, Alchemist, Lycan, Clinkz, Sniper.

* Heroes with blink or movement abilities, which are disabled by Pounce's leash: Anti-Mage, Earth Spirit, Faceless Void, Magnus, Mirana, Monkey King, Morphling, Pangolier, Phantom Assassin, Phoenix, Puck, Queen of Pain, Riki, Sand King, Spirit Breaker, Timbersaw, Tusk.

* Shadow Dance allows Slark to not be targeted by Unstable Concoction, making Alchemist stun himself and making himself vulnerable to the enemy.
* Dark Pact also allows him to just purge off the stun if timed correctly.
* Essence Shift will steal stats over long durations at a time should Alchemist lack the damage to kill Slark.

* Heroes without an escape mechanism: Shadow Fiend, Alchemist

Additional:
* Chemical Rage will rarely save Alchemist against Ursa's Fury Swipes.
* Enrage allows Ursa to both be a threat to Alchemist and avoid his over time damage.

* Heroes with mobility spells like Queen of Pain, Anti-Mage, Phantom Assassin, Riki, Puck, and Spirit Breaker that are cancelled by Frostbite can suffer greatly from the presence of Crystal Maiden. It is absolutely critical, however, to have followup from teammates, as all of the above heroes can make quick work of the squishy Crystal Maiden after they are released from her grip.

* Any Hero with high mobility will be neutralized by dream coil: Queen of Pain, Storm Spirit, Ember Spirit, Lycan, Bloodseeker, Anti-Mage, Timbersaw.

Additional:
* Puck will make a game of dodging as many Shadow Strikes as he can with Phase Shift. If he's a good player, he will also dodge Sonic Wave. If he's a great player, he will also dodge Scream of Pain. All through a single spell.
* Puck also has a silence to stop her blink with Waning Rift.
* Puck will have vision to hunt her down if she blinks into the trees with Illusory Orb.
* If Queen of Pain is under the effect of Dream Coil, she will be unable to blink out.

* Melee heroes that get kited easily have hard times dealing with Puck without any lockdowns, as Puck is one of the most mobile heroes. Heroes like Sven, Lifestealer, Ursa and Alchemist may have problems to get to Puck without proper initiation items. They also lack reliable lockdowns, as their disables are easily avoidable for Puck, or are just a soft disable.

* In general, attacks of the melee heroes who are entirely reliant on dealing physical damage and/or have very little to no area-of-effect abilities will make Underlord tickle and will have no effect against him, and will be unable to ambush Underlord and his team if Underlord chooses to use Fiend's GAte to get to a designated point of the map: Phantom Assassin, Terrorblade, Troll Warlord, Drow Ranger, Phantom Lancer, Chaos Knight, Sven, Wraith King, Bounty Hunter, Alchemist, Templar Assassin, Nyx Assassin, Bane.

* High priority targets like Queen of Pain, Drow Ranger, Ember Spirit can't get caught out from Lion's long range disables, making it harder to them fulfill their roles, and making it easy to target them.

* Heroes who rely on high mobility are especially vulnerable to Primal Roar: Storm Spirit, Ember Spirit, Queen of Pain.

* Heroes who struggle to fight back against Sven at any point in the game are at a severe disadvantage: Alchemist, Anti-Mage, Crystal Maiden.

* Ice Blast nullifies the health regeneration granted by Chemical Rage, which Alchemist greatly relies on to stay alive in battle.
* Alchemist tends to build Armlet of Mordiggian which can be deadly during Ice Blast.
Additional:
* Ice Blast cancels out Chemical Rage's rapid health regeneration. It can also take advantage of Alchemist's Armlet of Mordiggian toggling, as it will make HP drain insanely fast, essentially killing the bearer in no time.

* Ember's magic damage build is able to burst down Alchemist due to his low strength gain and Alchemist's normal item pick up.

* Alchemist has very bad armor and does not build armor items for the large majority of his build, so Jingu Mastery and Wukong's Command can be very deadly.
* Desolator, Sange and Yasha or Diffusal Blade can all be purchased to increase your damage against Alchemist or just to keep your movement speed high enough to match him while Chemical Rage is active.
* Monkey King is an agility hero and scales with armor, so Acid Spray loses it's effectiveness later in the game.

* Heroes that rely on their high mobility such as Queen of Pain, Slark and Weaver can be constantly engaged against due to your excellent ability to chase over any terrain. Make sure you carry true sight items (such as Dust of Appearance or Gem of True Sight) for invisible heroes that could potentially escape your clutches.

* Heroes reliant on abilities to output damage or escape can be shut down by Gust: Queen of Pain.

* Untouchable greatly reduces Chemical Rage's attack speed advantage.

* Heroes who rely on burst physical damage are affected by Lucky Shot's disarm: Terrorblade, Sven, Clinkz, Windranger, Alchemist, Dragon Knight, Legion Commander

* Alchemist's reliance on fast attack speed to do single-target damage makes him vulnerable to Static Link. It also goes through Black King Bar, which is a standard item on Alchemist.
* Eye of the Storm is great against high health strength heroes as it reduces their survivability to physical damage.
* Razor has early lane push to counter Acid Spray.

* Alchemist is a well-known Radiance carrier among other auras your illusions will benefit from. They also get the extra move speed and reduced base attack time from his Chemical Rage, and it's even better if you can catch him as his own rage is about to expire.
* Disruption will buy enough time for all allies to retreat when Alchemist starts to activate Unstable Concoction.

* Heroes who recklessly jump on Pudge with their gap-closing abilities will be easy targets for Pudge's Meat Hook and Dismember Combo: Phantom Assassin, Faceless Void, Queen of Pain etc.

* Quas-Exort Invoker can win the mid lane easily against Alchemist because Quas regeneration will nullify Acid Spray's damage over time and Exort damage bonus will allow Invoker to out last hit Alchemist.

* Heroes that rely on escapes to stay alive can be caught and locked down for a long time: Queen of Pain, Phantom Assassin

* Sprout is good for trapping melee carries with no escape abilities: Sven, Alchemist, Lifestealer etc.

* Visage can quickly kill heroes with low to medium base armor and no innate escape mechanism. Examples include Alchemist, Crystal Maiden and Zeus.