* With Vendetta, Nyx Assassin can move closely to Ember Spirit when he's farming with his Flame Guard and use Spiked Carapace with Impale to provide a reliable and long disable.
Additional:
* Spiked Carapace can be easily triggered by Flame Guard or Battle Fury, setting up a deadly Impale.

* Mind Flare does tons of damage against Lina because of her high intelligence.
* Vendetta can deal heavy damage to Lina while also burning her mana, preventing Lina from casting her abilities.
* Spiked Carapace can easily be used to counter Lina's abilities because of their long cast animation, and could probably kill Lina outright if Laguna Blade is reflected. However, Lina can counter this with Eul's Scepter of Divinity, a common item on Lina.

* Demonic Purge takes off Luna's superior mobility, removing the need for chasing her and allowing your team to reposition in team fights or escape when at low HP. If Shadow Demon has Aghanim's Scepter it will also take away glaive bounces and extra damage from Luna's passive. And Luna's commonly items Manta Style and Black King Bar does not work dispell to Demonic Purge
* Luna's illusions created by Disruption are very valuable with their Moon Glaives. These will effectively counter her pushing attempts and are painfully effective in team fights.
* Disruption can be used to save an ally from Eclipse.
* For the same reasons, Shadow Demon makes a very powerful ally for Luna when they are in the same team.
Additional:
* Demonic Purge takes off Luna's superior mobility, removing the need for chasing her and allowing your team to reposition in team fights or escape when at low HP. If Shadow Demon has Aghanim's Sceptre it will also take away glaive bounces and extra damage from Luna's passive.
* Luna's illusions created by Disruption are very valuable with their Moon Glaives. These will effectively counter her pushing attempts and are painfully effective in team fights.
* Disruption can be used to save an ally from Eclipse.
* For the same reasons, Shadow Demon is a very good ally for Luna when they are in the same team.

* Shadow Demon's Demonic Purge is undispellable.
* Heroes with undispellable debuffs will help identify the real Phantom Lancer through visual effects or debuff indicators, provided that it was cast on the real Phantom Lancer to begin with:
* Doom's Doom marks Phantom Lancer with a highly visible effect, and also silences and mutes him.
* Bloodseeker's Rupture shows a clear red trail effect on the real Phantom Lancer.
* Ancient Apparition's Ice Blast will only debuff Phantom Lancer and not his illusions.
* Grimstroke's Soulbind is undispellable.
* Shadow Demon's Demonic Purge is undispellable.
* Monkey King's Jingu Mastery is undispellable and puts a big yellow Mark over his head.

Additional:
* Phantom Lancer's strength is the sheer amount of illusions he can conjure, Dissimulate can be cast on an ally that he is focusing to quickly thin out his ranks
* Landing a upgraded Demonic Purge on the real Phantom Lancer prevents him from making very many illusions (His only source being Doppelganger), You can reapply as needed if you have the Shard
* Disrupting Phantom Lancer allows you to create multiple extra illusions with Juxtapose, As he is a common carrier of Diffusal Blade, you can also drain the mana of any nearby heros

* Heroes who can hide the Dueled target (Outworld Destroyer, Shadow Demon, Tusk, Phoenix with Aghanim's Scepter etc).

Additional:
* Disruption can save allies and mess up an initiation from an enemy Legion Commander. Using Disruption on your ally that is affected by Duel will leave her totally exposed without the benefit of the life steal from Moment of Courage. A precise decision to Disrupt Legion Commander or her victim is crucial to waste Duel's potential.
* Demonic Purge cannot be dispelled by a hard dispel from Press the Attack, which in turn can be dispelled by your ultimate.

* Melee carries such as Sven, Ursa or Lifestealer can be slowed and easily kited with Demonic Purge.

* Heroes with abilities that can save teammates are also effective such as Shadow Demon, Dazzle, Oracle, Bane, Pugna, Tusk, Winter Wyvern, Io, Underlord, Treant Protector and Keeper of the Light.

Additional:
* Be ready to save an ally from Omnislash with your Disruption.
* Spawning Juggernaut's illusions is a great deal, as his base attack time is low and he has a critical strike. Illusions will benefit from both.
* Demonic Purge will prevent Juggernaut's desperate attempt to flee using Blade Fury. However, it cannot stop him if he is using Town Portal Scroll.

* Heroes that lose a great amount of their tankiness and become easier to finish off: Bristleback, Spectre, Phantom Assassin, Enchantress, Dragon Knight.
* Once you have an Aghanim's Scepter, Shadow Demon instantly reaches a new power spike and becomes a counter for a variety of heroes that have strong passives.
* Heroes that lose a great amount of their tankiness and become easier to finish off: Bristleback, Spectre, Phantom Assassin, Enchantress, Dragon Knight.
* Heroes that lose a great amount of damage output and become less threatening: Phantom Assassin, Sven, Slark, Phantom Lancer.
* You can always stack camps and farm the scepter with Shadow Poison.

* Disruption can save an ally from a fatal Reaper's Scythe.
* Demonic Purge can remove Ghost Shroud, making Necrophos vulnerable to physical damage and preventing him from regenerating health.

* The huge physical damage taken from Vendetta will force Necrophos to use Ghost Shroud, which is good for a followup with Dagon and Ethereal Blade, both of which are common items on Nyx Assassin.
* Using Ghost Shroud also sets Necrophos up for a Mind Flare or Impale.

* Shadow Demon can waste precious seconds of Windrun with Disruption.
* Alternatively, Demonic Purge can be used to dispel it altogether, leaving her completely defenseless for 7 seconds.
* Disruption can be used to save an ally if they get stunned by Shackleshot.
Additional:
* Shadow Demon can waste precious seconds of Windrun with Disruption.
* Alternatively, Demonic Purge. can be used to dispel it altogether, leaving her completely defenseless.
* Disruption can be used to save an ally if they get stunned by Shackleshot.

* Many of Nyx Assassin's abilities are good against Windranger.
* Impale is great for stunning Windranger and allowing additional disables to be landed.
* Mind Flare is useful against Windranger's decent intelligence growth.
* Spiked Carapace is easy to use against Powershot.
* Vendetta allows Nyx Assassin to sneak up on and deal massive damage to Windranger without giving Windranger a chance to use Windrun to evade it.
* Nyx Assassin's item build allows him to easily deal with Windranger.

* Shadow Demon's Disruption will allow his allies to maneuver around you. It can also be used to protect an ally from your abilities, or Astral Imprisonment - Meteor Hammer combo.
* Disseminate turns your high damage Arcane Orb and Sanitiy's Eclipse against you and your teammates.
* Scepter upgraded Demonic Purge will break your Essence Flux passive for 7 seconds, preventing you from regaining mana, and severely hindering your damage output.

* Outworld Destroyer's high intelligence gain and fragility makes him an easy target for a massive Mana Burn, as well as killing him outwards with Nyx Assassin's high burst damage.
* Astral Imprisonment can be easily exploited by Nyx Assassin with his abilities. As long as Astral Imprisonment was not cast on Nyx Assassin, it will make an opportunity for an easy stun, either by Spiked Carapace (if Outworld Destroyer hid his allies or your allies) or Impale (if he hid himself). If Astral Imprisonment was cast on Nyx Assassin, using Spiked Carapace while banished will proc the stun after the disable, since Spike Carapace has a 0 second cast time and Astral Imprisonment deals damage right after the disable ends.
* An ill-timed Sanity's Eclipse and/or well timed Spiked Carapace can deal a lot of damage to Outworld Destroyer and stun him, unless Outworld Destroyer used Black King Bar beforehand.
Additional:
* Outworld Destroyer's high intelligence makes him a good target for Mind Flare.
* If timed correctly, Spiked Carapace will return the full damage from Sanity's Eclipse back to Outworld Destroyer. Even a reflected Arcane Orb can deal significant damage and make him vulnerable to a follow-up from Nyx Assassin.
* Spiked Carapace is also the perfect tool against Astral Imprisonment: if used on Nyx, he can reflect the damage back as he comes out of the prison by casting the ability while imprisoned.

* Heroes who can summon illusions and summons because Terrorblade has no abilities to deal with multiple enemies at once outside Reflection: Shadow Shaman, Naga Siren, Broodmother, Lycan, Enigma, Chaos Knight, Phantom Lancer, Shadow Demon, Dark Seer, Nature's Prophet, Invoker, Morphling, Visage, Grimstroke with Aghanim's Scepter.

* Nyx Assassin deals large amounts of pure damage with Vendetta and magical damage with Impale and Mind Flare, allowing him to ignore Terrorblade's armor and burst his low health pool down before he can use Sunder.
* Nyx Assassin commonly buys Urn of Shadows, Dagon and Meteor Hammer which deal magic damage that ignore Terrorblade's armor.
* However, Terrorblade is a natural Eye of Skadi and Black King Bar wielder, and once he gets those items, Nyx Assassin's solo kill potential against Terrorblade will be gone.

* Heroes with break can disable Untouchable for a while: Doom and Shadow Demon (via Aghanim's Scepter), Viper, Shadow Shaman with Hex Breaks talent.

* Vendetta can deal great damage against her. However, it requires an direct attack, so Nyx Assassin may have difficulties applying Vendetta on her.
* Enchantress's lack of mobility makes her a primary target for ganking with Vendetta.
* Mind Flare can deal a great damage against her due to being an Intelligence hero.
* Spiked Carapace can reflect Impetus and stun Enchantress.
Additional:
* Spiked Carapace reflects the damage from Impetus.
* Enchantress is a rather squishy hero, making her fall easily to Nyx Assassin's high burst damage.

* Heroes with high physical damage output but lack of reliable escape mechanisms are always a good target for a solo gank: Sniper, Shadow Fiend, Troll Warlord, Drow Ranger. Those heroes, however, are dangerous if they manage to close the gap, so take caution.

* Assassinate is easy to reflect with Spiked Carapace for massive damage.
* Shrapnel's area damage can set up an easy stun with Spiked Carapace, especially when combined with Vendetta.
* In the early game, Sniper's low health pool and high intelligence makes him easy prey for Nyx Assassin.

* Heroes with high physical damage output but lack of reliable escape mechanisms are always a good target for a solo gank: Sniper, Shadow Fiend, Troll Warlord, Drow Ranger. Those heroes, however, are dangerous if they manage to close the gap, so take caution.

* Nyx Assassin has a lot of burst damage from his Impale, Mind Flare, Dagon, and the bonus damage from Vendetta. All of this damage is enough to kill Drow Ranger.
* Nyx Assassin is usually invisible most of the time thanks to his ability Vendetta, which allows him to gank Drow Ranger easily.
* However, Gust is extremely dangerous for Nyx Assassin, as it's silence can render Nyx Assassin unable to lock down Drow Ranger. And if Gust hits Nyx Assassin while he is invisible with Vendetta, Drow Ranger will be able to detect him and foil his ganking attempts on her because Gust reveals invisible units.

* Heroes that can gain vision over trees to catch Tinker: Invoker, Shadow Demon, Batrider.

* Heat-Seeking Missile allow easy Spiked Carapace stuns.
* As a fragile hero that relies on mana and intelligence items, Tinker is vulnerable to Mana Burn.
* Nyx Assassin's stuns can interrupt Rearm and leave Tinker helpless.
Additional:
* Nyx Assassin's whole skillset is good against Tinker:
* Impale prevents Tinker from blinding Nyx Assassin or fighting back, while giving Nyx' allies time to catch up to Tinker's position.
* Mind Flare generally deals more damage to intelligence based heroes like Tinker.
* Spiked Carapace can stun Tinker at a moment of Nyx Assassin's choosing if March of the Machines has been cast. It is also quite easy to time Spiked Carapace against Heat Seeking Missiles.
* Vendetta allows Nyx to approach Tinker in the trees or wait for him in common hiding spots and deal heavy damage to his low armor.

* Heroes with high physical damage output but lack of reliable escape mechanisms are always a good target for a solo gank: Sniper, Shadow Fiend, Troll Warlord, Drow Ranger. Those heroes, however, are dangerous if they manage to close the gap, so take caution.

* Large area-of-effect with delay or require channeling: Enigma, Crystal Maiden, Invoker, Shadow Fiend, Pugna, Keeper of the Light, Dawnbreaker.

* Primal Beast really suffers against supports he cannot bully in the lane: this includes Dazzle, Shadow Demon and Dark Willow since they can use their respective abilities to stop Primal Beast from dealing burst damage, or make it hard for him to stay in range.

* Like above, supports with reliable stuns can be a massive problem and force Black King Bar in fights unideally, such as Shadow Shaman, Lion, Nyx Assassin.

* Hex abilities prevent attacking, ability and item usage, which is a severe problem for Phantom Assassin as it prevents her from using Black King Bar, the one item that helps protect her against the aforementioned dangers. Doom and Shadow Demon with Aghanim's Scepter also disables Phantom Assassin's Evasion and Critical Strike, removing much of her damage and survivabaility: Doom, Disruptor with Aghanim's Scepter, Dazzle with Aghanim's Shard

* Heroes with heavy early and mid-game magical damage are also problematic for Phantom Assassin due to being able to easily kill her before she can gain an item advantage over them: Lina, Necrophos, Nyx Assassin, Gyrocopter, Jakiro, Death Prophet.

* Heroes that can purge buffs can dispel Guardian Angel: Invoker, Shadow Demon, Oracle.

Additional:
* Demonic Purge can dispel Guardian Angel on the key target during combat, allow your allies to finish them.

* Heroes who can drain mana can make Omniknight useless after he uses one or two abilities: Lion, Anti-Mage, Nyx Assassin.

* Shadow Demon, Outworld Destroyer and Tusk can all save a Lasso'd teammate with their defensive spells.

* Nyx can walk into Firefly with Spiked Carapace and stun Batrider if he has no Spell Immunity, even if Batrider is focusing on other enemy hero.

* Spiked Carapace stops Snapfire's Mortimer Kisses.

* Nyx Assassin's high burst damage, excellent ganking potential and multiple disables pose a threat to Muerta at all stages of the game.
* Mind Flare allows Nyx Assassin to take advantage of Muerta's high intelligence and make a short work of her low health.
* Spiked Carapace and Vendetta allow Nyx to escape or initiate well against Muerta's low mobility.
* As with most retaliation based abilities, Spiked Carapace can easily take advantage of Gunslinger's stray shots.
* However, Muerta is a natural Black King Bar wielder. And if she succeeds to activate it before Nyx Assassin can ambush her, he will go down very quickly against Muerta as Spiked Carapace cannot pierce through debuff immunity at all.

* Disruption instantly removes Phantom Embrace, and can potentially save allies affected by Soulbind.
* Demonic Purge dispels Ink Swell.

* Nyx Assassin can simply activate Spiked Carapace while under many Invoker's abilities to stun him.
* Nyx Assassin takes advantage of Invoker's massive intelligence gain to do tons of damage using Mind Flare, as the spell does more damage based on the target's intelligence.
* Vendetta burns a large amount of Invoker's essential mana pool.

* Nyx's Spiked Carapace can reflect the damage of Sharpshooter, instantly killing hoodwink. Nyx can also use Vendetta to position himself in such a way to screen allies from Sharpshooter and catch Hoodwink by surprise.

* Her illusions with Desolate are very valuable, especially when they are usually paired with Radiance. Unlike blink or force movement, Spectral Dagger's escaping mechanic requires manual movement, and therefore Demonic Purge can hold her back really hard and allow your allies to finish her off.
* If she tries to kill you or any key ally with Haunt at any point of the game, remember to not panic and always use Disruption on the illusion, whether it is fake or the real Spectre herself. When the situation calls, Demonic Purge can save a second victim from a haunting Spectre.
* When upgraded by Aghanim's Scepter, Demonic Purge can remove Spectre from a fight by disabling Desolate and Dispersion, negating her damage and tankiness respectively.

* Crystal Maiden has a very bad movement speed, so Impale is easy to land against her. Furthermore, even while trapped by Frostbite, Nyx Assassin can still cast Impale.
* Crystal Maiden has very low armor, so Vendetta is very effective.
* Nyx Assassin has two ways to stop Freezing Field, provided she doesn't get a Black King Bar. He can either pop Spiked Carapace and simply walk into the field, or he can use Impale to interrupt the field, since Crystal Maiden has to channel it.
Additional:
* Spiked Carapace easily interrupts Freezing Field.
* Frostbite's damage over time sets up an easy Spiked Carapace stun.
* Crystal Maiden is extremely fragile and dies quickly to Nyx Assassin's burst damage.

* Shadow Demon's Shadow Poison can quickly stack to the point where Huskars generally low health is easily finished off.
* Shadow Demon's Disruption can turn Huskar's high attack speed and regeneration against him, It also makes him an easy target for Shadow Poison,
* Shadow Demon commonly builds a Meteor Hammer, allowing him to land a heavy stun on Huskar
* Shadow Demon's upgraded Demonic Purge breaks Huskar, It also pierces Spell Immunity, Without his passive for 7 seconds Huskar quickly falls in battle
* However note that Shadow Demon is a squishy target and you can often overwhelm him if he is alone, But he can still Disrupt you to escape
Additional:
* Shadow Poison can quickly stack up on Huskar, And with his naturally low health you don't need as many stacks to be effective.
* Disruption turns Huskars high attack speed against him, They also have the highest survivability as illusions due to his passive Berserker's Blood, It also allows you to put Shadow Poison stacks on him,
* Dissimulate turns Huskar's burning damage against his team, You can cast it on an ally who is taking a bunch of Burning Spear stacks and cause Huskar to take high amounts of damage as well
* Scepter upgraded Demonic Purge is your most effective weapon against him, It's 7 second Break causes him to quickly die in battle

* Nyx Assassin can reflect Life Break with Spiked Carapace.

* Spiked Carapace can be used to reflect Illuminate damage and stun Keeper of the Light.
* Vendetta allows Nyx Assassin to follow Keeper of the Light around if he tries to split-push.
* Keeper of the Light is very squishy and will very quickly die to Vendetta and it's followup abilities.

* Impale and Spiked Carapace can be used to cancel Dismember easily, and can even do so when Pudge uses it on Nyx Assassin, if timed correctly.

* Ravage's travel time allows Nyx Assassin to easily stun Tidehunter with Spiked Carapace.
* Vendetta can instantly deplete Tidehunter's low mana pool, especially in the early game, potentially preventing Tidehunter from casting Ravage.

* Nyx Assassin's high burst damage can be the bane of Dark Willow, as her low health makes it difficult to survive long enough to escape through Shadow Realm.
* Spiked Carapace can be triggered by walking deliberately into Bramble Maze, leaving Dark Willow stunned and defenseless.

* Alchemist is a well-known Radiance carrier among other auras your illusions will benefit from. They also get the extra move speed and reduced base attack time from his Chemical Rage, and it's even better if you can catch him as his own rage is about to expire.
* Disruption will buy enough time for all allies to retreat when Alchemist starts to activate Unstable Concoction.

* Impale and Spiked Carapace interrupts Upheaval with ease.
* Warlock's low health pool, mobility, and high intelligence gain makes him a prime target for Nyx Assassin's burst damage.

* Vendetta disables Vengeance Aura and allows him to attack Vengeful Spirit with Impale and Mind Flare.
* Spiked Carapace is easy to use against a Wave of Terror or Magic Missile.

* Vendetta burns a significant amount of mana on hit, and the damage from the ability drains Medusa's mana pool even further.
* Due to the passive nature of Mystic Snake and Split Shot, it can possibly proc Nyx's Spiked Carapace if he's within range of Medusa's abilities and isn't invisible.
* Medusa lacks single target damage, making Nyx with Aghanim's Scepter extremely hard to deal with if Medusa is the team's main damage source.
Additional:
* With her passive Split Shot, Medusa can be easily interrupted by Spiked Carapace during combat, especially during her precious Stone Gaze.
* Mana Burn quickly destroys Mana Shield, especially if Medusa only increases her mana pool by bolstering intelligence (which has the added bonus of increasing Mana Burn's damage).
* Uncontrollable damage from Mystic Snake and Split Shot can trigger Spiked Carapace.
* Medusa lacks single target damage, making a Burrowed Nyx Assassin hard to kill.

* Disruption can protect Shadow Demon's allies from Fortune's End, preserving healing or buffs. It can also catch Oracle's allies, allowing Shadow Poison to be used without being dispelled.
* Demonic Purge prevents over-time healing during False Promise, such as Purifying Flames and Urn of Shadows. If he has Aghanim's Scepter, this issue can persist for longer or on multiple allies.
* It will not, however, prevent healing from instant abilities, items, or auras, making Mekansm a good choice against him.

* Heroes with either magical, physical or pure damage burst can often kill Chen or his allies before he can use Hand of God: Lina, Luna, Techies, Shadow Fiend, Pugna, Nyx Assassin.

* Heroes with summons or illusions makes Sacred Arrow harder to land: Shadow Demon, Phantom Lancer, Nature's Prophet.

* Shadow Demon's Demonic Purge with Aghanim's Scepter disables Bristleback's passives.

* Heroes with break abilities: Shadow Demon (with Aghanim's Scepter), Viper.

* Heroes with invisibility: (Riki, Clinkz, Nyx Assassin.

* Heroes with ways to protect themselves or allies from Spirit Breaker's initiation: Shadow Demon, Outworld Destroyer, Omniknight, Dawnbreaker.

* Heroes with silence and mana drain abilites, as Ancient Apparition relies entirely on his abilities: Invoker, Silencer, Nyx Assassin, Skywrath Mage, Shadow Shaman, Lion and etc.

* Heroes that can pick you off: Clinkz, Nyx Assassin, Puck, Riki.

* Heroes with either magical, physical or pure damage burst: Bane, Ember Spirit, Leshrac, Lina, Luna, Nyx Assassin, Phantom Assassin, Skywrath Mage, Tinker, Ursa, Void Spirit.

* Slow-moving projectiles: Skywrath Mage, Tinker, Necrophos

Additional:
* Skywrath Mage's low health makes him rather easy prey for Nyx Assassin and his lack of armor generally means he'll take the full brunt of a Vendetta strike.
* Mind Flare turns Skywrath Mage's high intelligence growth against him and deals heavy damage.
* Spiked Carapace gives Nyx some degree of protection against Skywrath's spells.

* Similarly, they can negate your X Marks The Spot & Torrent combo by protecting your target when you use Return. Good candidates to negate your combo include Outworld Destroyer and his Astral Imprisonment, and Shadow Demon and his Disruption.
* Heroes with hide abilities can often dodge a Ghostship just before it hits.
* Similarly, they can negate your X Marks The Spot & Torrent combo by protecting your target when you use Return. Good candidates to negate your combo include Outworld Destroyer and his Astral Imprisonment, and Shadow Demon and his Disruption.
* A Eul's Scepter of Divinity can also do the trick, but, unlike the previously mentioned abilities, you can only use it on yourself and not your allies.

* Heroes with hiding abilities can protect disabled allies: Outworld Destroyer, Shadow Demon, Tusk, Phoenix with Aghanim's Scepter.

* Heroes that lose a great amount of damage output and become less threatening: Phantom Assassin, Sven, Slark, Phantom Lancer.
* Once you have an Aghanim's Scepter, Shadow Demon instantly reaches a new power spike and becomes a counter for a variety of heroes that have strong passives.
* Heroes that lose a great amount of their tankiness and become easier to finish off: Bristleback, Spectre, Phantom Assassin, Enchantress, Dragon Knight.
* Heroes that lose a great amount of damage output and become less threatening: Phantom Assassin, Sven, Slark, Phantom Lancer.
* You can always stack camps and farm the scepter with Shadow Poison.

* Nyx Assassin, Bounty Hunter and Slark can all sneak up and kill Shadow Shaman, Nyx being particularly deadly. Shadow Shaman must watch out for Slark carefully, as he can break either (but not both unless he makes a mistake) of Shadow Shaman's disables, with Dark Pact and leap out of a serpent ward ring. These heroes, however, rely heavily on escape and are themselves not very durable and none of them can survive a full lockdown with Mass Serpent Ward. Having Sentry Wards can turn Shadow Shaman from prey to predator.

* Melee carries such as Sven, Ursa or Lifestealer can be slowed and easily kited with Demonic Purge.

Additional:
* Shadow Demon's Demonic Purge renders Ursa useless even through Black King Bar as it slows him, continually purges his Overpower charges and can not be dispelled by Ursa's Enrage.
* Disruption is a good way to save teammates against Ursa. Disrupting Ursa is also a good way to kite him, as it can not be dispelled by Enrage.

* Shadow Demon with an Aghanim's Scepter will use Demonic Purge to disable Curse of Avernus and the passive component of Borrowed Time. If this is combined with a silence, Borrowed Time will not trigger at all.
* Even without Aghanim's Scepter, he can still waste Borrowed Time with Disruption. Curse of Avernus fully works on illusions, turning the passive ability against him.

* Nyx Assassin might not kill Abaddon with his nuke, but a support Abaddon will struggle to protect an ally from him.

* Shadow Demon's spammable illusions can be used to scout Techies' Proximity Mines.

* In the laning stage, making illusions of Venomancer will turn his Poison Sting back at him, making for an easy gank at level one, and for later when your mid comes for ganks.

* Disruption sets up Anti-Mage for a chain disable. The illusions will deal extra damage due to Mana Break.
* Shadow Poison hits Anti-Mage even after he's Blinked away.
* If Shadow Demon has Aghanim's Scepter, Demonic Purge can break Mana Break and Counterspell, weakening both his offense and defense.
Additional:
* While it is unwise to encounter Anti-Mage alone, Disruption's considerable cast range can become a perfect setup for any hard-disable to follow up. If he is pinned down, Anti-Mage will quickly face his demise when the illusions deplete his already low mana pool. Manta Style will easily allow him to escape, however.
* The illusions can be controlled to quickly sap mana from any other target, making Anti-Mage one of the most valuable targets to disrupt.

* Disruption can banish Faceless Void or an ally in Chronosphere, making it a less effective ability.
* Faceless Void's illusions created by Disruption will not get stunned by Chronosphere, allowing Shadow Demon to attack Faceless Void in his Chronosphere.
* Casting Disruption after releasing Shadow Poison charges will make Time Walk unable to backtrack the damage.
* Shadow Poison is a good way to deal damage as the initial damage and the release damage can't both be Time Walked at the same time.
* Demonic Purge is a great slow, useful to force out a Time Walk early and can break Time Lock with Aghanim's Scepter.

* Spiked Carapace can stop Dawnbreaker's Solar Guardian which will eliminate her global presence and limits her movement around the map.
Additional:
* Spiked Carapace interrupts Starbreaker before Dawnbreaker has her Aghanim's Shard, as well as Solar Guardian during the initial channel, making her ineffective at joining and dealing damage in teamfights.
* The slow projectile and damage over time effect of Celestial Hammer makes it easy to stun Dawnbreaker if she attemps to engage or chase.

* Spiked Carapace allows Nyx to get an easy long-duration stun on Weaver once he uses Shukuchi, and then he can follow up with Impale.
* Vendetta works as a great setup for both Impale and Spiked Carapace and can deal decent damage to Weaver. Additionally he can neutralize The Swarm beetles due to his invisibility duration.

* The constant dispel from Demonic Purge will make any attempt to save the victim or himself by Surge become futile. For what it's worth, Demonic Purge will also dispel Ion Shell.

* Illusory Orb is easy to reflect with Spiked Carapace, either stunning Puck and setting up an easy Impale or forcing a premature Phase Shift.
* Puck is an intelligence hero that tends to build intelligence items, making it vulnerable to Mana Burn.
* An ill-timed Phase Shift can easily set Puck up to be stunned by Impale.
* Puck's low base armor and below average agility gain mean it is always susceptible to Vendetta.
Additional:
* Nyx Assassin can take advantage of every one of Puck's weaknesses. His entire skill set is very effective in countering Puck.
* Because Illusory Orb is such a slow moving projectile, Nyx Assassin can simply walk into the orb and activate Spiked Carapace, stunning Puck and setting up an easy Impale. This can be circumvented by using Phase Shift while the orb is traveling, however, that means that Puck cannot use Phase Shift to dodge any other skill nor use it to safely blink away from a fight.
* Puck is an intelligence hero that likes to build intelligence items such as Eul's Scepter of Divinity, Scythe of Vyse, and Dagon. This makes Mind Flare that much more deadly against Puck.
* An ill-timed Phase Shift can turn into an easy setup for Impale.

* Mana Burn removes much-needed mana for Ball Lightning.
* Spiked Carapace triggers on Static Remnant for an easy stun.
Additional:
* Vendetta is capable of removing most of Storm Spirit's large mana pool, along with dealing heavy damage and quickly depleting his chances of escaping a gank or fight.

* Nether Blast's animation makes it easy to time Spiked Carapace for a stun.
* Pugna has the largest intelligence gain in the game, making him a prime target for Mana Burn.
* Pugna needs to channel Life Drain, making him easy to hit with Impale.
Additional:
* Due to Pugna's incredible intelligence growth and terrible strength growth, Nyx should always be able to take you out with his combo, with or without an added Dagon. Mind Flare will deal a large amount of damage in particular, especially in the late game.
* Spiked Carapace is also a great tool versus Pugna. A good player will wait for you in Vendetta until you farm a creep wave with Nether Blast and reflect it back at you as their initiation and setup for Impale.

* A good Nyx can reflect Queen of Pain's Sonic Wave with his Spiked Carapace, or even initiate a gank on her in Vendetta while she farms a creep wave with Scream of Pain.
* Her strength to intelligence ratio is bad enough that he should be able to kill her without even requiring a Dagon, provided he can get his full combo off.

* Heroes that lose a great amount of damage output and become less threatening: Phantom Assassin, Sven, Slark, Phantom Lancer.
* Once you have an Aghanim's Scepter, Shadow Demon instantly reaches a new power spike and becomes a counter for a variety of heroes that have strong passives.
* Heroes that lose a great amount of their tankiness and become easier to finish off: Bristleback, Spectre, Phantom Assassin, Enchantress, Dragon Knight.
* Heroes that lose a great amount of damage output and become less threatening: Phantom Assassin, Sven, Slark, Phantom Lancer.
* You can always stack camps and farm the scepter with Shadow Poison.

* Last Word is extremely easy to reflect with Spiked Carapace for large amounts damage, due to triggering when Nyx Assassin casts a spell, but can still silence Nyx Assassin. It also has the added bonus of dealing more damage the more Intelligence Silencer has.
* Glaives of Wisdom quickly builds Silencer's Intelligence, making him a particularly prime target for Mana Burn.
* Silencer rarely builds survivability items, nor is he able to steal much Intelligence while surrounded by his team, and so is an excellent target for Vendetta.
* Silencer has no reliable way of dealing with a burrowed Nyx, and also lacks the ability to prevent Nyx from escaping with Vendetta,
Additional:
* Silencer is rather squishy and has poor mobility without items, making him an easy target for Nyx.
* Silencer's intelligence steal ability is a complete disadvantage against Nyx Assassin as Mind Flare will deal increasing damage for each point of intelligence Silencer has stolen, turning Silencer's intelligence steal against him.

* Heroes with high physical damage output but lack of reliable escape mechanisms are always a good target for a solo gank: Sniper, Shadow Fiend, Troll Warlord, Drow Ranger. Those heroes, however, are dangerous if they manage to close the gap, so take caution.

* Spiked Carapace reacts on any of the damage over time from Phoenix's abilities and can interrupt Sun Ray and Icarus Dive.

* Nyx Assassin's Spiked Carapace will stun Leshrac when hit by any of his AOE abilities.
* Mind Flare deals high damage due to Leshrac's high intelligence gain.
* Vendetta burns a large amount of Leshrac's essential mana pool.

* Enigma is fragile, and lacks escapes, being dependent on Blink Dagger for mobility. Ganking Heroes or Heroes with burst damage will likely kill him before he can do anything. Such Heroes include: Lina, Lion, Luna, Puck, Slark, Nyx Assassin, etc.

Additional:
* Enigma's uncontrollable damage from Malefice and Midnight Pulse make him easy to stun with Spiked Carapace.
* Black Hole can be easily interrupted by Impale or Spiked Carapace.

* Heroes that can punish aggressive heroes, such as: Leshrac, Shadow Demon, Pugna, Death Prophet.

* Disruption will save Shadow Demon's teammates from being killed by Counter Helix or Culling Blade.
* Demonic Purge slows Axe to a crawl, making him nearly useless after initiating. If Shadow Demon has Aghanim's Scepter, it will also break Counter Helix.
* Demonic Cleanse clears Battle Hunger and Aghanim's Shard Counter Helix Damage Reduction, both allowing targets to escape and reducing your own survivability.
Additional:
* While it is unwise to encounter Axe alone, Disruption can be used to save your allies from Axe's initiate Berserker's Call, or, if timed correctly, from his Culling Blade.
* Illusions spawned from Axe has the Counter Helix passive, which with deal some nasty damage if an enemy focuses them
* Your upgraded Demonic Purge breaks Axe's primary damage output: Counter Helix, This can be used on him during Berserker's Call to seriously hinder him.
* Demonic Cleanse will clear Battle Hunger, which is Axe's method of catching heroes, and Shard upgraded Counter Helix's Damage Reduction, which is one of Axe's primary survivability abilities.

* Heroes with magical or pure damage output will not have any problems against Atrophy Aura at all: Luna, Lina, Jakiro, Pugna, Bane, Snapfire, Muerta, Nyx Assassin, Enigma, Tinker, Witch Doctor, Zeus, Crystal Maiden.

* Heroes with summons or illusions can counter Flux, such as Beastmaster , Chen, or Shadow Demon.