* Heroes with abilities or items that can silence or disable Anti-Mage for long periods of time will prevent him from Blinking away: Lion, Silencer, Shadow Shaman, Grimstroke, Witch Doctor, Riki, Faceless Void, Skywrath Mage, Puck.

* Heroes with cleave or multi-target attacks can quickly take on Familiars and reduce Visage's firepower like Gyrocopter, Kunkka, Magnus and Medusa.

* A couple of nukers and disablers on the same lane can finish a squishy Luna efficiently despite a teammate's assistance: Sven + Shadow Shaman.

* Heroes that relies on armor or other type of physical damage negation are easy for Gyrocopter to take down during the early game with his magical damage: Axe, Dragon Knight, Sven.

* All of Shadow Shaman's abilities totally ruin Terrorblade: Ether Shock destroys his illusions, Hex prevents him from using Sunder or Manta Style in bad situations, Shackles not only that prevent him from using Sunder, but he has no way to cancel it and Mass Serpent Ward can help Shadow Shaman push faster than Terrorblade even in Metamorphosis.
Additional:
* Ether Shock, Mass Serpent Wards summoned from both, Mass Serpent Ward and Aghanim's Shard upgraded Shackles can do great damage to both, Terrorblade and his illusions.
* Hex prevents Terrorblade from using Sunder or Manta Style in bad situations. Hex can also destroy one of his illusions.
* Shackles can damage Terrorblade and prevent him from using his abilities and items, whether to fight, survive, or dispel it in any way while also healing Shadow Shaman in process. In addition, Terrorblade has no solutions to cancel it. Aghanim's Shard upgraded Shackles can also summon four more Mass Serpent Wards to attack Terrorblade while he is disabled.

* Flak Cannon destroys Terrorblade's illusions very quickly.

* Shackles and Hex can both be used on Muerta while in Pierce the Veil, potentially wasting it until she gets Black King Bar.
* Ether Shock and Shackles can deal high damage to Muerta while she is affected by Pierce the Veil.
* However, Mass Serpent Ward cannot hurt Muerta while Pierce the Veil is active.

* Heroes with high physical and magical damage alike are a huge hazard for Muerta, as they can deal serious damage to her even if she has Pierce the Veil active: Luna, Lina, Tusk, Broodmother, Shadow Fiend, Ember Spirit, Gyrocopter, Vengeful Spirit, Arc Warden, Medusa, Shadow Shaman.

* Shackles and Mass Serpent Ward instantly destroy Refraction

* Weak damage but high tick rate or persist in a long time: Slark, Gyrocopter, Queen of Pain, Shadow Shaman (Shackles), Jakiro, Pugna, Doom
* Heroes that can quickly deal damage to her, regardless of how weak they are, can easily break through her Refraction:
* Multiple attackers thanks to summoned units or clones: Meepo, Witch Doctor, Lycan, Enigma, Shadow Shaman
* Multiple attackers thanks to illusions: Phantom Lancer, Chaos Knight, Naga Siren (bonus for her Ensnare). Also despite the visual effects, Templar Assassin does not spill damage against illusions or buildings, so she is not a really good hero to clean up illusions.
* Weak damage but high tick rate or persist in a long time: Slark, Gyrocopter, Queen of Pain, Shadow Shaman (Shackles), Jakiro, Pugna, Doom

* Heroes with both illusions and summons, for Io has nothing to deal with multiple enemies at once outside from Spirits's weak area-of-effect: Beastmaster, Broodmother, Chaos Knight, Lycan, Naga Siren, Nature's Prophet, Phantom Lancer, Shadow Shaman, Terrorblade, Visage, Warlock, Wraith King.

* Homing Missile can be used to cancel escape attempts with Relocate.
* Flak Cannon allows Gyrocopter to attack both, Io and his Tethered target, especially when upgraded with Aghanim's Scepter.
* Rocket Barrage and Call Down allow Gyrocopter to deal serious damage to both Io and his Tethered target.
Additional:
* Homing Missile can be used to cancel escape attempts with Relocate.
* Flak Cannon allows Gyrocopter to attack both, Io and his Tethered target, especially when upgraded with Aghanim's Scepter.
* Rocket Barrage and Call Down allow Gyrocopter to deal serious damage to both Io and his Tethered target.

* Heroes with illusions and summons can be hard for Phantom Assassin to deal with, as she lacks any AoE abilities to deal with them without items: Broodmother, Phantom Lancer, Chaos Knight, Lycan, Naga Siren, Shadow Shaman, Visage, Nature's Prophet, Terrorblade, Warlock, Wraith King.

* Heroes with heavy early and mid-game magical damage are also problematic for Phantom Assassin due to being able to easily kill her before she can gain an item advantage over them: Lina, Necrophos, Nyx Assassin, Gyrocopter, Jakiro, Death Prophet.

* Sven is very vulnerable to chain stun such as Lion, Shadow Shaman or Magnus.

* Heroes that relies on armor or other type of physical damage negation are easy for Gyrocopter to take down during the early game with his magical damage: Axe, Dragon Knight, Sven.

* Flak Cannon destroys Phantom Lancer's illusions very quickly.
Additional:
* Flak Cannon and Call Down destroy Phantom Lancer's illusions very quickly.

* Shackles prevents Chen from acting, and damages him while healing Shadow Shaman, also allowing Shadow Shaman's allies to kill him faster. Aghanim's Shard upgraded Shackles can also summon four more Mass Serpent Wards to attack Chen while he is disabled. And to make things worse, Chen has no way to cancel Shackles on his own, and must rely on outside from {U:Centaur Conqueror} or {U:Mud Golem} under his control.
* Ether Shock and Mass Serpent Ward can often not only kill Chen's allies before he can save them with Hand of God, but they can also be used to destroy Chen's creeps easily thanks to their high damage and area-of-effect.
* Hex will prevent Chen from any attempt to save himself or his allies with Hand of God.
Additional:
* Shackles prevents Chen from acting, and damages him while healing Shadow Shaman, also allowing Shadow Shaman's allies to kill him faster. Aghanim's Shard upgraded Shackles can also summon four more Mass Serpent Wards to attack Chen while he is disabled. And to make things worse, Chen has no way to cancel Shackles on his own, and must rely on {U:Centaur Conqueror} or {U:Mud Golem} creeps under his control to be able to do so.
* Ether Shock and Mass Serpent Ward can often not only kill Chen's allies before he can save them with Hand of God, but they can also be used to destroy Chen's creeps easily thanks to their high damage and area-of-effect.
* Hex will prevent Chen from any attempt to save himself or his allies with Hand of God.

* Flak Cannon and Call Down can easily clear Naga Siren's illusions.

* Shadow Shaman's Mass Serpent Ward together with Ether Shock can easily kill lots of Treants if played defensively.
* Hex and Shackles can disrupt Nature's Prophet's escape attempts with Teleportation.
Additional:
* Mass Serpent Ward can kill lots of treants if played defensively.
* Mass Serpent Ward, Hex, and Shackles can catch and kill a Nature's Prophet trying to use Teleportation.

* Shadow Shaman's long disables are effective at kiting and wasting the duration of Battle Trance.
* Mass Serpent Ward are especially effective against Troll Warlord during Battle Trance, as trapping him inside them during the duration is effectively another hard disable, as Troll cannot attack the wards or use Phase Boots to escape.

* Hex's instant cast time will force Brewmaster into the awkward situation of needing some form of spell immunity or block to prevent being immediately hex upon blinking in, or wait until Shaman has used all his crowd control before entering a fight.
* Brewmaster also has no defense against Shadow Shaman lockdowns.

* Shadow Shaman's many disables can lock down Weaver. Even with Linken's Sphere, Weaver might not be able to escape should Shadow Shaman uses Shackles quickly enough following Hex.
* Mass Serpent Wards can make short work of Weaver once he is locked down.

* Flak Cannon rips through Tombstone's zombies.
Additional:
* Flak Cannon enables Gyrocopter to clear the zombies easily.

* Heroes with break can disable Untouchable for a while: Doom and Shadow Demon (via Aghanim's Scepter), Viper, Shadow Shaman with Hex Breaks talent.

* Heroes with long lockdowns: Shadow Shaman, Legion Commander.

* Any hero who can counter-initiate in anticipation without getting caught in Reverse Polarity: Sven, Omniknight, Enigma, Luna, Naga Siren, Mars, Jakiro, Venomancer, Elder Titan, Faceless Void, Rubick, Keeper of the Light, Pugna, Invoker, Spectre, Alchemist, Treant Protector, Lina, Oracle, Zeus, Shadow Shaman, Phoenix, Razor, Huskar, Batrider, Kunkka, Tidehunter, Wraith King, Sand King, Medusa, Dawnbreaker.

* Heroes with channeling spells because Shadow Fiend has nothing to cancel channeling outside of Requiem of Souls: Bane, Enigma, Pudge, Shadow Shaman, Dawnbreaker, Warlock, Crystal Maiden.

* Heroes with silence and mana drain abilites, as Ancient Apparition relies entirely on his abilities: Invoker, Silencer, Nyx Assassin, Skywrath Mage, Shadow Shaman, Lion and etc.

* Viper cannot interrupt heroes with powerful channeling abilities: Bane, Enigma, Shadow Shaman, Warlock

* Heroes that can keep Marci for a long time in one place so she can't pursue her targets, like Bane, Lion, Shadow Shaman, Invoker, Disruptor and Kunkka.

Additional:
* Shadow Shaman can provide an excellent counter-initiation against her Rebound. His abilities can shut down any of her tower dive attempts in the laning phase.
* Shackles keeps Marci stunned for an extended time, wasting her ultimate. A combo with Mass Serpent Ward only makes things worse for her, as her armor is low.

* Heroes who can clear the waves of Enigma's Eidolons: Lina, Luna, Dawnbreaker, Jakiro, Shadow Shaman, Death Prophet, Keeper of the Light, Invoker, Leshrac, Puck.

* Heroes with strong area-of-effect damaging and/or disabling abilities will be able to intercept Underlord and his team when they exit from Fiend's Gate: Luna's Aghanim's Scepter upgraded Eclipse, Dawnbreaker's Solar Guardian, Axe's Berserker's Call, Mars's Arena of Blood, Jakiro's Macropyre, Dual Breath and Ice Path, Naga Siren's Song of the Siren, Razor's Eye of the Storm and Plasma Field, Lina's Light Strike Array, Broodmother's Spinner's Snare from Aghanim's Scepter, Elder Titan's Earth Splitter and Echo Stomp, Alchemist's Unstable Concoction and Acid Spray, Queen of Pain's Sonic Wave, Dark Seer's Wall of Replica and Vacuum, Venomancer's Noxious Plague and Poison Nova from Aghanim's Scepter, Oracle's Fortune's End and Rain of Destiny from Aghanim's Shard, Bloodseeker's Blood Rite, Enigma's Black Hole and Midnight Pulse, Shadow Fiend's Requiem of Souls, Batrider's Aghanim's Scepter upgraded Flaming Lasso, Firefly, Flamebreak and Sticky Napalm, Ancient Apparition's Ice Blast, Sand King's Epicenter, Sand Storm and Burrowstrike, Gyrocopter's Call Down, Ember Spirit's Sleight of Fist, Death Prophet's Exorcism and Silence, Monkey King's Wukong's Command, Crystal Maiden's Freezing Field, Muerta's The Calling, Medusa's Stone Gaze, Zeus's Nimbus from Aghanim's Scepter. Dark Willow's Bramble Maze, Pangolier's Swashbuckle, Grimstroke's Soulbind, Ink Swell and Stroke of Fate, Earthshaker's Echo Slam and Fissure, Puck's Dream Coil and Waning Rift, Winter Wyvern's Winter's Curse, Magnus's Reverse Polarity.

* Hex can be used immediately to destroy Spectre's illusion when she Haunts.
* Shadow Shaman can use Shackles to lock down Spectre for his team.
* Shadow Shaman's Mass Serpent Ward and Ether Shock help him push lanes and end the game early before Spectre can come online and take over the late game.

* Flak Cannon destroys Chaos Knight's illusions very quickly.

* Can easily interrupt and disable Spirit Breaker with hex if being charged.

* Mass Serpent Ward rips apart Huskar quickly due to his poor armor.
* As soon as Huskar jumps in, he will be vulnerable to Shadow Shaman's disables if he does not have Black King Bar.

* In general, squishy heroes that rely on escape often struggle against the amount of disables Shadow Shaman can bring. Queen of Pain, Anti-Mage and Storm Spirit are among these.

* Hex greatly reduces Timbersaw's mobility.
* The stun and damage over time from Shackles mitigates Reactive Armor's HP and armor regen.

* Like above, supports with reliable stuns can be a massive problem and force Black King Bar in fights unideally, such as Shadow Shaman, Lion, Nyx Assassin.

* Shadow Shaman has many disables to lock down Queen of Pain, preventing her from Blinking away, even through Linken's Sphere or her spell block talent.
* Mass Serpent Ward can tear through Queen of Pain's low health pool once she's locked down by Hex & Shackles.

* Flak Cannon and Call Down will shred Meepo's clones.
* Homing Missile can catch and single out retreating Meepos, making them an easy kill.

* Hex abilities can cancel the channelling of Fiend's Grip : Lion, Shadow Shaman, Dazzle from Aghanim's Shard with upgraded Poison Touch.

* Heroes with long or multiple disables will prevent Legion Commander from winning Duels: Shadow Shaman, Lion

* Heroes that relies on armor or other type of physical damage negation are easy for Gyrocopter to take down during the early game with his magical damage: Axe, Dragon Knight, Sven.