* Enemies that possess high defenses through magic resistance, damage reduction, or high regeneration will make it difficult to whittle their health down to get to Reaper's Scythe's threshold. Such heroes include Bristleback (although only from behind), Spectre, Ursa, and Dragon Knight.

* Slardar's level 25 talent makes Corrosive Haze undispellable, thus providing his allies vision of Slark.

* Corrosive Haze reveals Pudge's location, making it hard for him to use Meat Hook from the fog of war on Slardar's teammates or Slardar himself.
* Slithereen Crush interrupts Pudge while he is using Dismember.
* Guardian Sprint allows Slardar to avoid Meat Hook.
Additional:
* While Slardar has Guardian Sprint activated, Rot cannot slow him and Meat Hook is easier to avoid.
* Slithereen Crush allows Slardar to interrupt Dismember at close range (when Slardar is not a target).
* Corrosive Haze reveals Pudge's location, making it very difficult for him to land hooks from the fog.

* Bristleback is one of the hardest heroes to gank with a Meat Hook and Dismember combo, and attempts to do so sometimes backfire on Pudge.
Additional:
* Pudge is particularly susceptible to Bristleback's Viscous Nasal Goo and Quill Spray due to his naturally low armor and poor agility gain.
* Bristleback, in combination with his strength gain, high health, common itemization for magic resistance and damage reduction from Bristleback makes him a poor target for Pudge.

* Corrosive Haze works much like Track, giving the enemy team vision over Riki. While it doesn't give a movement speed or gold bonus, it instead can melt Riki's armor and Slardar can use Guardian Sprint to catch up to him.
* Slardar's Aghanim's Shard, causes Slithereen Crush to apply Corrosive Haze even if Slardar does not have vision over him.
Additional:
* Corrosive Haze makes Riki completely vulnerable to Slardar and his allies, as Riki has no easy way of dispelling it.
* Slardar's physical damage with Slithereen Crush and Bash of the Deep amplified by Corrosive Haze can easily kill Riki.

* Quill Spray will hit Riki even when he is invisible.
* Cloak and Dagger's bonus backstab damage is rendered irrelevant against Bristleback.
* Smoke Screen does not stop Bristleback's passive from activating.
* Due to Bristleback's natural tankiness, he is an ideal Gem of True Sight carrier, directly countering Riki's invisibility.
Additional:
* The bonus Backstab damage from Cloak and Dagger is rendered irrelevant with Bristleback and hurts Riki more than him because of the passive Quill Spray.
* Riki can still get damaged by Bristleback's Quill Spray while invisible, and it can be hard to deal with in lane.
* Bristleback is not too bothered by Smoke Screen. Though he cannot use Quill Spray manually inside it, it still procs passively when he takes damage from the back. The movement speed from Warpath allows him to get out of the area easily.
* Due to Bristleback's natural tankiness, he is an ideal Gem of True Sight carrier.
* Riki rarely buys Silver Edge to break Bristleback's passive because the invisibility aspect of it is redundant.

* While Slardar has Guardian's Sprint activated, Powershot cannot slow him and is easier to avoid.
* Slithereen Crush and Bash of the Deep help Slardar put Windranger in place, even when she uses Windrun to escape.
* Corrosive Haze from Slardar is very effective against Windranger's already low armor. This becomes even worse if she has Aghanim's Scepter-upgraded Windrun, because it also reveals her position and allowing his allies to use their abilities on Windranger.
* Note that the invisibility provided by Aghanim's Scepter-upgraded Windrun is not broken upon attacking, casting abilities or using items, so it's vital to cast Corrosive Haze beforehand.

* Combo Quill Spray and items Blade Mail can easily trigger from Focus Fire damage.
Additional:
* Using Focus Fire on Bristleback tends to fare badly for Windranger, as he can trigger passive Quill Sprays many times, especially when she attacks him from behind. In addition, Windrun does not protect her from both Viscous Nasal Goo and Quill Spray, rendering her helpless.
* Bristleback's natural tankiness makes it hard for Windranger to effectively burst her down throughout the game.
* Bristleback tends to continuously spam Viscous Nasal Goo to slow down Windranger when she uses Windrun to escape, potentially allowing him to outrun her with his Warpath stacks.
* Bristleback can build Lotus Orb to reflect Shackleshot and Focus Fire back at Windranger.

* Corrosive Haze and Bash of the Deep will make short work of Huskar's low armor, even if Slardar is alone.

* The damage from Burning Spear can be reduced by turning away from Huskar.
* Bristleback can bait Huskar into using Life Break on him, then turn around and receive very little damage.
Additional:
* Bristleback's tankiness and Bristleback allow him to outlast Burning Spears' damage-over-time at almost any point in the game. In addition, if Huskar chooses to cast Life Break on Bristleback, Bristleback can simply turn around before it hits and receive little damage.
* Viscous Nasal Goo will reduce Huskar's low armor even further, and Quill Spray and Warpath will tear him down extremely quickly.

* Slardar can chase Dragon Knight down with Guardian Sprint and stun him with both Slithereen Crush and his passive Bash of the Deep. He can also use Corrosive Haze to whittle Dragon Knight's armor.

* Viscous Nasal Goo slows down Dragon Knight and lowers armor, locking him down and making him more vulnerable.

* Crystal Maiden's already low armor and easily interruptible ultimate, Freezing Field can make Slardar her worst nightmare. Crystal Maiden also often builds Glimmer Cape which is revealed by Corrosive Haze.

* Viscous Nasal Goo can hinder Crystal Maiden's already abysmal mobility, which allows Bristleback (or his teammates) to run her down and kill her.
* Bristleback frequently builds Blade Mail, which can quickly kill Crystal Maiden if her ultimate is used while he is under its effect.
* The passive part of Bristleback will trigger many, many times under the damage from Freezing Field, and as the stacks increase, the damage output from each successive cast (or proc) will eat away at Crystal Maiden's small HP pool.

* Corrosive Haze provides True Sight on its target, exposing Bounty Hunter's position regardless of Shadow Walk.
* Guardian Sprint gives a very high movement speed bonus, allowing him to chase Bounty Hunter even if Slardar is tracked.
Additional:
* Bounty Hunter's Shadow Walk is rendered useless with Corrosive Haze and makes Bounty Hunter an easy target for Slardar and his team.

* Bristleback's Viscous Nasal Goo can catch and slow Bounty Hunter. Warpath and Quill Spray can defeat him quickly due to his small HP pool when compared to Bristleback's.

* Heroes who can provide True Sight or semi-reveal enemy heroes as Nature's Prophet is prone to buying Shadow Blade: Bounty Hunter, Slardar, Spectre, Zeus, Spirit Breaker.

* Heroes that have AoE damage: Lina, Keeper of the Light, Timbersaw, Leshrac, Bristleback, Axe.

* Slardar can attack through Plague Wards and gain Bash of the Deep charges, and Templar Assassin can spill Psi Blades through Plague Wards too.

* Heroes with damage-over-time abilities easily allow Bristleback to turn his back in order to proc Bristleback continuously and to massively reduce to damage dealt to him: Arc Warden, Venomancer, Luna.

* Heroes with high physical damage can damage Lifestealer more than he can heal: Bristleback, Clinkz, Luna,Shadow Fiend, Slardar, Terrorblade

* Heroes with high physical damage can damage Lifestealer more than he can heal: Bristleback, Clinkz, Luna,Shadow Fiend, Slardar, Terrorblade

* Tiny's nonexistent armor in the early game makes him very vulnerable to Quill Spray's large amounts of physical damage.
* Bristleback decreases Tiny's high burst damage against Bristleback.
* Viscous Nasal Goo can slow Tiny to a crawl and allows Bristleback to easily kite him with his high movement speed and Quill Spray's long range, as Tiny has no ability to escape.

* Bristleback's abilities are nearly useless for Rubick to Spell Steal, as he does not gain the bonuses from Warpath.
Additional:
* Rubick deals little damage on his own, and Bristleback can simply shrug off all his spells and chase Rubick down with his Quill Spray and the damage bonus from Warpath.
* Rubick does not tend to charge forward in teamfights, stay in the front lines under most circumstances, yet effective casts of Quill Spray and Viscous Nasal Goo requires the opposite as they require multiple casts and close range to add up stacks.
* Rubick does not benefit from Warpath through casting the stolen spell.

* Slardar can use Guardian Sprint with Blink Dagger or Shadow Blade to get close, and Slithereen Crush will stun Sniper and slow him, making him vulnerable to Slardar's teammates.
* Corrosive Haze lowers Sniper's armor and makes Sniper's Shadow Blade useless, easily killing him with a few attacks.

* Quill Spray quickly destroys Chaos Knight's Phantasms.

* Lone Druid and The Spirit Bear cannot burst down Bristleback due to Bristleback
* Bristleback can easily run to Lone Druid without any hesitation, with Viscous Nasal Goo to reduce armor and slow the Spirit Bear or Lone Druid and Quill Spray can deal damage to both Lone Druid and the Spirit Bear at the same time

* Shadow Fiend, a normal Shadow Blade builder often relies on its invisibility to escape fights. Corrosive Haze reveals Shadow Fiend and also weakens his already low armor.

* Slardar can reveal Clinkz with Corrosive Haze and make him easy to kill, and his Bash of the Deep also hits hard against Clinkz's naturally low health pool.
* Slardar's Guardian Sprint can catch up with Clinkz's Skeleton Walk.
* The stun and slow from Slardar's Slithereen Crush can hold Clinkz in place.
Additional:
* Clinkz survivability depends entirely on Skeleton Walk. Corrosive Haze not only makes its invisibility useless, but also makes Clinkz even more vulnerable to physical damage.

* Quill Spray's constant AoE damage will hit Dark Willow even in Shadow Realm. Its automatic damage will hurt her if she tries to get close and use Bedlam.

* Corrosive Haze followed by Slithereen Crush takes advantage of Alchemist's main weakness, being physical damage before he has the change to improve his surviability with items.
* Bash of the Deep will deal lots of damage during the laning phase.

* Lycan's wolves deal little damage to Bristleback, and are easily killed by Quill Spray, even when they're invisible.
* Lycan's lack of burst damage makes it very hard for him to kill Bristleback, especially when his back is turned.
Additional:
* Quill Spray can be used to kill Lycan's summons.
* Bristleback allows him to stay alive against Lycan while dishing out counter attacks
* He can overpower Lycan with his Warpath instead.

* Quill Spray is very effective against Io, as it has very low armor and has to stay close to the fight to not break its Tether.

* Slardar is one of the few meele heroes who can lane against Ursa in the early game, out harassing him with Bash of the Deep, and running away from a bad engagement with Guardian Sprint
* Corrosize Haze can force Ursa to cast Enrage defensively instead of offensively
* With Corrosize Haze, Slardar's team can quickly dispatch of Roshan, denying one of Ursa's greatest advantages

* Corrosive Haze hinders Nyx Assassin's ganking attempts with Vendetta, as well as reducing his armor and make him very vulnerable due to his low health pool.
* Guardian Sprint allows Slardar to catch up with Nyx Asssassin and finish him off if he has vision over him.

* Quill Spray will hit Sand King inside Sand Storm, damaging him and putting Sand King's Blink Dagger on cooldown, preventing him from escaping.
* Epicenter's numerous damage ticks will trigger Bristleback's passive repeatedly during teamfights.

* Arc Warden has relatively lower armor and mobility, which makes him an easy target to apply Quill Spray and Viscous Nasal Goo stacks.
* Arc Warden also does not like to build a Silver Edge as it takes a long time to build up and may slow down the timings for other important items needed in the game like Gleipnir.
* However, do note that in a game where Arc Warden's team has many jumping capabilities or good passives, like a Tidehunter or Spectre, a Silver Edge becomes incredibly valuable on Arc Warden as not only can he run away from the jumps, he effectively gets 2 breaks, and Bristleback may not be the best pick.

* The brutal physical damage of Slithereen Crush and Bash of the Deep can quickly remove Void Spirit's shield and stun him for a while.
* Corrosive Haze provides vision of Void Spirit while he is running away and Guardian Sprint allows Slardar to quickly close the gap

* Quill Spray destroys spiderlings, and hits Broodmother even when she's regenerating in her webs. This makes Bristleback one of her hardest counters in lane.
Additional:
* Bristleback reduces most of Broodmother's and her spiderlings' damage.
* Quill Spray will hit any spiders in its proximity, hindering Broodmother's fighting and farming capabilities.

* Corrosive Haze will reveal Treant Protector even when he is under the effects of Nature's Guise.

* Heroes with spells that negate invisibility such as Bounty Hunter, Zeus and Slardar prevent her from saving her allies with Moonlight Shadow.

* Heroes who can provide True Sight are always credible threats: Slardar, Bounty Hunter, especially Zeus since his Lightning Bolt provides True Sight without the need to detect her beforehand to apply the debuff. So even a late-coming Zeus can easily scout a large area to reveal her, and she cannot purge herself from his sight with the dispel talent.

* Axe, Bristleback, Centaur Warrunner, Spirit Breaker, Pudge, Huskar, Wraith King, Doom: These heroes are too tanky for Puck to burst down. Also, all of them have spells which can deal with and shut Puck down reliably.

* Bounty Hunter and Slardar both have ultimates (Corrosive Haze and Track) that reveal Invoker through Ghost Walk.

* Slardar's Slithereen Crush allows him to stun Spectre and illusions, and Corrosive Haze prevents her from juking with Spectral Dagger.

* Heroes who can stun multiple units at once: Dark Willow, Spirit Breaker, Slardar, Invoker, and Tidehunter.

* Quill Spray usually hits Meepo's clones, although Bristleback cannot turn his back when rooted with Earthbind.

* Heroes with armor reducing abilities greatly hinder Visage's defense like Slardar and Dazzle.

* Other heroes who has armor and slow debuffs won't allow Medusa to disengage from combat: Tidehunter, Bristleback, Slardar.

* Other heroes who has armor and slow debuffs won't allow Medusa to disengage from combat: Tidehunter, Bristleback, Slardar.

* Bristleback's constant harass from Quill Spray will greatly hurt Enigma's laning and kill his Eidolons.
* However, Bristleback has no way of canceling Black Hole at all. And Bristleback is not a hero that goes for disabling items to counter that problem.

* Bristleback's tankiness and damage reduction from the rear makes him very hard for Phantom Lancer to chase and finish off, due to his lack of burst damage.
* Quill Spray quickly destroys Phantom Lancer's illusions.
* Bristleback's passive costs no mana, meaning that it will continue to trigger even if Phantom Lancer drains Bristleback's mana with Diffusal Blade.
Additional:
* Bristleback's tankiness and damage reduction from the rear makes him very hard for Phantom Lancer to chase and finish off, due to his lack of burst damage.
* Quill Spray destroys Phantom Lancer's illusions.
* Bristleback's passive costs no mana, meaning that it will continue to trigger even if Phantom Lancer drains Bristleback's mana with Diffusal Blade.

* Slardar deals entirely physical damage. He does not have to worry about Counterspell.
* Slithereen Crush and Bash of the Deep prevent Anti-Mage from using Blink, the latter even if Anti-Mage activates Black King Bar.
* Corrosive Haze allows allies to take down Anti-Mage before he has a chance to Blink, and maintains vision over him even if he does Blink away.
Additional:
* Slithereen Crush and Bash of the Deep deals physical damage, bypassing the magic resistance bonus from Counterspell
* Corrosize Haze significantly increases the damage dealt against Anti-Mage, and makes it harder for him to flee with Blink, although Anti-mage can block its casting with with Counterspell

* Weaver relies on Shukuchi to escape and kite enemy heroes. Slardar's Corrosive Haze lowers armor and reveals Weaver, who is already a very frail target.
* Weaver usually builds Linken's Sphere, Corrosive Haze can be used to pop the spell block, additionally the level 25 undispellable talent will prevent Weaver from removing Corrosive Haze with Time Lapse, allowing allied heroes to use their abilities on Weaver.
Additional:
* Corrosive Haze lowers armor and reveals Weaver during Shukuchi, who is already a frail target. In addition, Weaver usually builds Linken's Sphere, and Corrosive Haze can be used to "pop" the spell block. His level 25 talent can also make Corrosive Haze undispellable by Time Lapse, which puts Weaver in an even worse situation.
* Guardian Sprint can dodge Weaver's bugs with the movement speed bonus.

* Macropyre's frequent damage ticks causes Bristleback to activate repeatedly, resulting in free damage as long as Bristleback faces away from Jakiro.

* Heroes who can continue dealing damage even while being stunned: Luna, Razor, Axe, Bristleback, Leshrac, Death Prophet, Jakiro.

* Heroes who can stop Axe from getting close will severely inhibit his presence in fights: Bristleback, Crystal Maiden, Batrider, Arc Warden, Winter Wyvern, Clockwerk

* Heroes with damage-over-time abilities easily allow Bristleback to turn his back in order to proc Bristleback continuously and to massively reduce to damage dealt to him: Arc Warden, Venomancer, Luna.

Additional:
* Quill Spray and Bristleback harass Luna more efficiently than she does with Lucent Beam.
* Bristleback helps return a lot of damage to Luna’s team if she uses her nukes on him and he has his back to her, and her only way to counter this is by buying Silver Edge.
* Viscous Nasal Goo and Warpath are enough to outrun a speedy Luna.
* Bristleback tends to be a frequent carrier of Crimson Guard and Eternal Shroud, which are good protection from Moon Glaives and Eclipse.
* For the same reasons, Bristleback makes a very powerful ally for Luna when they are in the same team.

* With armor items like Solar Crest or Assault Cuirass combined with Bash of the Deep, Slardar can easily tank the Duel, If not dueled himself, he can drop Legion Commander's armor during duel and/or buff his teammate and save them, leaving her only the choice of dueling supports which can also be saved with fast Blink into Slithereen Crush.

* Fortune's End cannot dispel Warpath stacks on Bristleback or Quill Spray stacks on allies.
* Bristleback can heavily reduce Oracle's damage output. With it, Oracle may accidentally heal Bristleback with Purifying Flames, especially if Bristleback has bonus magic resistance.