Tinker
* Even though Luna has a hard time laning against Tinker because of 
Heat-Seeking Missile and 
Laser, she can win against him in late game once she buys 
Black King Bar, as none of Tinker's spells can bypass spell immunity.
* 
Lucent Beam and 0.25 
Eclipse Lucent Mini-stun talent for Eclipse can be used to cancel 
Rearm and prevent Tinker's escape attempts with 
Boots of Travel. Luna can also use Lucent Beam and Eclipse if she is blinded with Laser.
* An ill-timed and ill-positioned 
Blink Dagger will make Tinker a very easy target for Luna's Eclipse that can quickly tear him to shreds. This can get even better if Luna buys 
Aghanim's Scepter and combines it with 0.25 Eclipse Lucent Mini-stun talent for Eclipse.
* However, Luna needs to approach Tinker carefully, as Tinker is a natural 
Scythe of Vyse wielder, and if he gets a jump on Luna first, he will be able to use it to disable and burst down Luna before she can use Black King Bar, Lucent Beam or Eclipse.
Additional:
* Even though Luna has a hard time laning against Tinker because of Heat-Seeking Missile and Laser, she can win against him in late game once she buys Black King Bar, as none of Tinker's spells can bypass spell immunity.
* Lucent Beam and 0.25 Eclipse Lucent Mini-stun talent for Eclipse can be used to cancel Rearm and prevent Tinker's escape attempts with Boots of Travel. Luna can also use Lucent Beam and Eclipse if she is blinded with Laser.
* An ill-timed and ill-positioned Blink Dagger will make Tinker a very easy target for Luna's Eclipse that can quickly tear him to shreds. This can get even better if Luna buys Aghanim's Scepter and combines it with 0.25 Eclipse Lucent Mini-stun talent for Eclipse.
* However, Luna needs to approach Tinker carefully, as Tinker is a natural Scythe of Vyse wielder, and if he gets a jump on Luna first, he will be able to use it to disable and burst down Luna before she can use Black King Bar, Lucent Beam or Eclipse.
Nyx Assassin
* Even though Nyx Assassin can easily kill Luna with his high burst damage, Luna can also do the same to him if he is not careful.
* Lucent Beam can deal a fair amount of damage to Nyx Assassin if he has no 
Spiked Carapace available to use. Although Luna should be patient using Lucent Beam on Nyx Assassin when he uses Spiked Carapace.
* As Luna commonly buys Black King Bar, she can use it to freely attack Nyx Assassin whenever he tries to defend himself with Spiked Carapace during teamfights. Luna can also buy 
Eye of Skadi and 
Manta Style to survive Nyx Assassin's burst damage and distract him.
* Though 
Vendetta can deal serious damage to Luna and avoid Eclipse, smart Luna will always buy 
Dust of Appearance to provide vision on Nyx Assassin to her and her team.
Additional:
* Even though Nyx Assassin can easily kill Luna with his high burst damage, Luna can also do the same to him if he is not careful.
* Lucent Beam can deal a fair amount of damage to Nyx Assassin if he has no Spiked Carapace available to use. Although Luna should be patient using Lucent Beam on Nyx Assassin when he uses Spiked Carapace.
* As Luna commonly buys Black King Bar, she can use it to freely attack Nyx Assassin whenever he tries to defend himself with Spiked Carapace during teamfights. Luna can also buy Eye of Skadi and Manta Style to survive Nyx Assassin's burst damage and distract him.
* Though Vendetta can deal serious damage to Luna and avoid Eclipse, smart Luna will always buy Dust of Appearance to provide vision on Nyx Assassin to her and her team.
Tinker
* Tinker is heavily dependent on active abilities and 
Doom prevents him from using any of them.
Additional:
* Tinker is heavily reliant on casting his spells and Doom can disable all of his abilities and items. An Aghanim's Scepter only makes it harder for Tinker to survive.
Nyx Assassin
* A well-timed Doom prevents Nyx Assassin escaping with Vendetta and fighting back with Spiked Carapace.
* Doom's high health also allows him to easily shrug off Nyx Assassin's burst damage and fend him off.
Tinker
* Night Stalker is one of the best heroes to find (and silence) Tinker in the trees during Dark Ascension.
Additional:
* Night Stalker can easily find Tinker in the trees during 
Dark Ascension.
* 
Void's mini-stun will stop Rearm and 
Keen Conveyance
* 
Crippling Fear's silence will prevent Tinker from fighting back, as Tinker relies on his spells.
Nyx Assassin
* Heroes that have a weak laning stage: 
Spectre, 
Nyx Assassin, 
Clockwerk, 
Spirit Breaker, 
Omniknight, 
Pudge.
Tinker
* 
Pounce prevents Tinker from blinking away.
* Slark frequently builds 
Shadow Blade, which allows him to approach Tinker unnoticed. Since Tinker's farming usually covers a significant amount of area on the map, Sentry Wards may not be cost effective.
* 
Shadow Dance allows Slark to detect both common and unusual wards. Eliminating common ward causes Tinker trouble farming many lanes if he does not know who may be waiting to jump on him. Slark is also uniquely able to identify some of the less common wards used by Tinker, such as those placed on the cliffs at map edges which Tinker uses to give him vision over the trees he uses to hide in.
* Slark's extremely high move speed from Shadow Dance, potentially stacked with Shadow Blade, allows him to easily follow Tinker between lanes, especially if Tinker has pushed the lanes out.
* 
Dark Pact dispels Laser's blind.
Nyx Assassin
* Heroes who build Black King Bar as either core or situational item will be able to fight back against Nyx Assassin and freely attack him as Spiked Carapace cannot pierce spell immunity at all: 
Axe, 
Broodmother, 
Dawnbreaker, 
Enigma, 
Huskar, 
Jakiro, 
Legion Commander, 
Lina, 
Luna, 
Lycan, 
Slardar, 
Slark, 
Troll Warlord, 
Witch Doctor.
Tinker
* 
Press the Attack can dispel Laser's blind while providing great attack speed and health regeneration.
* Once caught in a 
Duel, Tinker, who completely relies on his spells to be effective, has little chances of survival with his low health pool and armor.
Nyx Assassin
* Duel's long duration prevents Nyx Assassin escaping from Vendetta. With Aghanim's Scepter, she can also bypass Spiked Carapace.
Tinker
* Heroes with abilities that blind or cause Legion Commander to miss will prevent her from winning Duels: 
Arc Warden, 
Keeper of the Light, 
Riki, 
Tinker
Tinker
* Anti-Mage's high mobility from Blink and tendency to build 
Battle Fury makes him strong against split-pushing heroes: 
Nature's Prophet, Tinker, and Arc Warden.
Additional:
* Tinker is fragile and vulnerable against carries like Anti-Mage.
* 
Mana Break burns away his mana pool and deals bonus physical damage.
* Tinker's massive mana pool makes 
Mana Void deal large amount of damage, and can be used to cancel a Keen Conveyance teleport.
* 
Blink gives Anti-Mage many options, like disjointing Heat Seeking Missiles. He can use Blink to wait out of sight for a split pushing Tinker or chase a blinking Tinker into trees.
* Tinker doesn't want any of his spells reflected back at him through 
Counterspell.
Nyx Assassin
* Heroes who build mana boosting items but have low mana regeneration are especially vulnerable against Mana Break and Mana Void: 
Timbersaw, Slark, 
Shadow Fiend, 
Clinkz, 
Bristleback Nyx Assassin, 
Magnus
Tinker
* Illusion heroes, such as 
Naga Siren, 
Phantom Lancer, 
Chaos Knight, 
Terrorblade will become strong against Tinker in the late game. Without Aghanim's Scepter Tinker is forced to defensively disarm heroes with Laser, leaving illusions free to deal physical damage which Tinker's low armor makes highly effective. In addition, 
Mjollnir or Battle Fury, two common pickups against illusion heroes, don't work well on Tinker at all.
Nyx Assassin
* Nyx Assassin's skillset is mostly single-targeted, therefore he will have difficulties against heroes with illusions and summons: Naga Siren, Broodmother, Lycan, 
Visage, Phantom Lancer. And to make things worse, Nyx Asassin is not a common Battle Fury, 
Maelstrom, Mjollnir, 
Gleipnir or 
Radiance wielder to counter this problem.
Nyx Assassin
* Even though Visage's Familiars from 
Summon Familiars are fragile and can be killed quickly with Nyx Assassin's high burst damage, they can deal many instances of damage quickly, minimizing the effectiveness of Spiked Carapace.
* 
Gravekeeper's Cloak and tanky item builds make Visage hard for Nyx to kill with his burst damage. 
Aghanim's Shard upgraded Gravekeeper's Cloak also allows Visage to use 
Stone Form to both recover himself and stun Nyx Assassin if he is close enough to Visage.
* Visage's long range on 
Soul Assumption and 
Grave Chill make him hard to escape from, and Soul Assumption's low cooldown outmatches Spiked Carapace.
Nyx Assassin
* 
Corrosive Haze hinders Nyx Assassin's ganking attempts with Vendetta, as well as reducing his armor and make him very vulnerable due to his low health pool.
Tinker
* His global teleportation with Boots of Travel and Rearm is easily countered with 
Haunt, and Spectre can reach him anywhere on the map.
* He is squishy, and if alone 
Desolate will kill him very fast.
* 
Dispersion can reflect and reduce his burst damage.
Tinker
* Zeus can easily reveal Tinker's location in the trees with 
Thundergod's wrath.
* When Zeus has an Aghanim's Scepter, he can use his 
Nimbus, together with 
Lightning Bolt to interrupt Tinker's Keen Conveyance channelling and cancel Tinker's Blink Dagger.
Additional:
* Due to Tinker's low health pool, Zeus can easily burst Tinker down, while also cancelling Rearm.
* Once Zeus gets Aghanim's Scepter, he will gain Nimbus, which allows him to scout out Tinker on the map, especially when he is pushing lanes while hiding in the trees.
Tinker
* Tinker's Laser has very little effect on Jakiro.
* Tinker has to sit still for a short period of time due to Rearm, not only making it easy to catch him with Ice Path, but also by stunning him while he is Rearming, Jakiro generally spell Tinker's doom.
* With s high area-of-effect and strong damage-over-time capabilties, Jakiro can quickly burn through his 
Defense Matrix, and at the same time lock down his Blink Dagger. Both of which he relies heavily to survive on.
Nyx Assassin
* Heroes who build Black King Bar as either core or situational item will be able to fight back against Nyx Assassin and freely attack him as Spiked Carapace cannot pierce spell immunity at all: Axe, Broodmother, Dawnbreaker, Enigma, Huskar, Jakiro, Legion Commander, Lina, Luna, Lycan, Slardar, Slark, Troll Warlord, Witch Doctor.
Tinker
* Heroes with good counter-push abilities to clear creep waves can hinder Jakiro's early pushing ability: 
Death Prophet, 
Sniper, Tinker, 
Windranger.
Nyx Assassin
* Lycan's high health allows him to easily shrug off Nyx Assassin's burst damage and fend him off.
* As Lycan commonly buys Black King Bar, he can use it to freely attack Nyx Assassin and chase after him with 
Shapeshift.
Nyx Assassin
* Centaur's low Intelligence makes 
Mind Flare do low damage.
* With some creative skill builds, Centaur's Hoof Stomp stun duration should always last longer than Spiked Carapace stun, so escaping unscathed is hard for Nyx.
* With Blink Dagger and detection, Centaur can devastate Nyx in the open.
* However, bear in mind that Nyx can also easily initiate on Centaur Warrunner as well if he uses Spiked Carapace in anticipation, and with Vendetta. The damage from Retaliate will be reflected back to Centaur Warrunner, stunning him with no chance to react after he's revealed himself, and should guarantee a successful 
Impale.
Tinker
* Tinker relies on his high mobility from Boots of Travel and Blink Dagger to survive. Those items don't help him if Spirit Breaker manages to cast Charge of Darkness on him.
* Spirit Breaker can easily cancel Rearm and Boots of Travel.
Nyx Assassin
* Nyx Assassin wants to start ganking as soon as he gets his Vendetta. Keeping him Tracked prevents him from ganking, and thus from doing his job in the game.
* Nyx Assassin has a lot of armor and health regen, making the nuke damage from Shuriken Toss very good against him.
Additional:
* 
Track hinders Nyx Assassin's ganking attempts with Vendetta, making him an easy kill for gold as well.
Tinker
* 
Shadow Wave provides good sustain against Tinker's spammable abilities.
* 
Shallow Grave can stop Tinker from bursting down a target.
Nyx Assassin
* A well-timed 
Berserker's Call can expose Nyx Assassin while he is invisible with Vendetta, and prevent him from using Spiked Carapace.
* Axe can use 
Battle Hunger's damage over time to minimialize effects of Spiked Carapace.
* Axe's high health also allows him to easily shrug off Nyx Assassin's burst damage and fend him off. Especially since Axe is a common 
Heart of Tarrasque wielder, which can completely eliminate any chance for Nyx Assassin to kill Axe alone.
* 
Culling Blade can often kill Nyx Assassin as he is very fragile and vulnerable to damage while Spiked Carapace is on cooldown.
Additional:
* A well-timed Berserker's Call can expose Nyx Assassin while he is invisible with Vendetta, and prevent him from using Spiked Carapace.
* Axe can use Battle Hunger's damage over time to minimialize effects of Spiked Carapace.
* Axe's high health also allows him to easily shrug off Nyx Assassin's burst damage and fend him off. Especially since Axe is a common Heart of Tarrasque wielder, which can completely eliminate any chance for Nyx Assassin to kill Axe alone.
* Culling Blade can often kill Nyx Assassin as he is very fragile and vulnerable to damage while Spiked Carapace is on cooldown.
Nyx Assassin
* 
Cyclone from Storm in 
Primal Split can waste Nyx's Spiked Carapace, since its duration is shorter than the Cyclone's.
Nyx Assassin
* 
Blade Fury makes Juggernaut immune to all Nyx's abilities, except Vendetta.
* 
Omnislash. and 
Swiftslash can burst Nyx down, ignoring Spiked Carapace. However, Vendetta can be used to escape, canceling Omnislash/Swiftslash.
Additional:
* Juggernaut's entire skillset greatly counters Nyx Assassin's Spiked Carapace, his most important ability.
* Blade Fury allows Juggernaut to freely attack Nyx Assassin, and deal heavy damage to Nyx Assassin. Nyx Assassin cannot counter Blade Fury with Spiked Carapace because Blade Fury gives Juggernaut spell immunity. And besides Vendetta, Nyx Assassin has no other way of dealing damage to Juggernaut while he is spell immune.
* 
Healing Ward allows Juggernaut to recover himself and his allies from Nyx Assassin's damage output.
* Omnislash and Swiftslash from Aghanim's Scepter can quickly finish off Nyx Assassin, and just like Blade Fury, Nyx Assassin cannot counter neither Omnislash and Swiftslash from Aghanim's Scepter with Spiked Carapace because both abilities render Juggernaut invulnerable. And if Nyx Assassin has no Vendetta available to use for escaping, both abilities will kill him very quickly before he can do anything.
* Overall, any attempt for Nyx Assassin to gank and kill Juggernaut will hurt Nyx Assassin more than Juggernaut.
Tinker
* Tinker is an easy target for Earth Spirit to initiate on. He likes to split push lanes once he acquires Boots of Travel and Earth Spirit can jump him with his Rolling Boulder and disable him to buy enough time for his teammates to come and assist Earth Spirit.
* The huge range of Stone Remnant and Rolling Boulder enables Earth Spirit to stop Tinker from teleporting to his fountain since Tinker tends to buy Blink Dagger most of the time to escape.
Tinker
* Rocket Flare can find Tinker if he blinks into the treeline, and Hookshot will prevent him from teleporting out.
* Battery Assault makes Tinker unable to Rearm by stunning him repeatedly.
Additional:
* Clockwerk can easily catch a split pushing Tinker with his 
Hookshot and prevent him from escaping with 
Power Cogs and 
Battery Assault. Clockwerk can also find a Tinker hiding in trees with his 
Rocket Flare.
* Clockwerk usually buys a 
Blade Mail, which does lots of damage to Tinker if he gets hit by his abilities (especially March of the Machines).
Nyx Assassin
* Dragon Knight's heavy armor negates Vendetta's burst physical damage. His large HP pool also gives him a good chance of surviving Nyx Assassin's follow-up nuke damage.
Tinker
* Beastmaster's Hawk can find Tinker easily while he is pushing or blinking into trees.
Tinker
* Tinker who can't fight multiple heroes will suffer greatly against Ransack and Earthbind.
Tinker
* Similarly, heroes with low cooldown teleports can be afraid to split push against X Marks the Spot, such as Tinker and Nature's Prophet.
* In general, highly mobile heroes like 
Earth Spirit or 
Storm Spirit are at a disadvantage against X Marks the Spot.
* Similarly, heroes with low cooldown teleports can be afraid to split push against X Marks the Spot, such as Tinker and Nature's Prophet.
Additional:
* 
X Marks the Spot can be used to prevent Tinker from escape with Blink Dagger or Keen Conveyance, discourage him from snapping farm and snapping gank. However, in later game, it'll be much more difficult because Tinker can buy Black King Bar or 
Linken's Sphere to prevent Kunkka from placing X on him, or 
Eul's Scepter of Divinity to prevent the recall.
Nyx Assassin
* Heroes who build Black King Bar as either core or situational item will be able to fight back against Nyx Assassin and freely attack him as Spiked Carapace cannot pierce spell immunity at all: Axe, Broodmother, Dawnbreaker, Enigma, Huskar, Jakiro, Legion Commander, Lina, Luna, Lycan, Slardar, Slark, Troll Warlord, Witch Doctor.
Nyx Assassin
* Heroes who rely on damage over time as Spiked Carapace can block and reflect only one instance of damage: 
Venomancer, Huskar, 
Ember Spirit, 
Dark Seer, 
Sand King, 
Doom, Dawnbreaker. However, this also means they are easily stunned.
Nyx Assassin
* Heroes with very little to no area-of-effect abilities will struggle greatly against Broodmother: Sniper, 
Phantom Assassin, Nyx Assassin, 
Bane, Visage, 
Bounty Hunter.
Nyx Assassin
* Heroes who build Black King Bar as either core or situational item will be able to fight back against Nyx Assassin and freely attack him as Spiked Carapace cannot pierce spell immunity at all: Axe, Broodmother, Dawnbreaker, Enigma, Huskar, Jakiro, Legion Commander, Lina, Luna, Lycan, Slardar, Slark, Troll Warlord, Witch Doctor.
Nyx Assassin
* Heroes who rely on damage over time as Spiked Carapace can block and reflect only one instance of damage: Venomancer, Huskar, Ember Spirit, Dark Seer, Sand King, Doom, Dawnbreaker. However, this also means they are easily stunned.
Nyx Assassin
* Heroes who rely on damage over time as Spiked Carapace can block and reflect only one instance of damage: Venomancer, Huskar, Ember Spirit, Dark Seer, Sand King, Doom, Dawnbreaker. However, this also means they are easily stunned.
Tinker
* Heroes that can gain vision over trees to catch Tinker: 
Invoker, 
Shadow Demon, 
Batrider.
Nyx Assassin
* In general, attacks of the melee heroes who are entirely reliant on dealing physical damage and/or have very little to no area-of-effect abilities will make Underlord tickle and will have no effect against him, and will be unable to ambush Underlord and his team if Underlord chooses to use 
Fiend's GAte to get to a designated point of the map: Phantom Assassin, Terrorblade, Troll Warlord, 
Drow Ranger, Phantom Lancer, Chaos Knight, 
Sven, 
Wraith King, Bounty Hunter, 
Alchemist, 
Templar Assassin, Nyx Assassin, Bane.
Nyx Assassin
* Impale and Spiked Carapace stun can be instantly dispelled by Aphotic Shield.
* Abaddon can use Borrowed Time and easily heal for the duration of Borrowed Time by Nyx's burst damage.
Nyx Assassin
* Nyx Assassin might not kill Abaddon with his nuke, but a support Abaddon will struggle to protect an ally from him.
Tinker
* Skywrath Mage stands perfectly on the center line against Tinker, thanks to his nuke and silence. Also, thanks to his abilities, he can quickly kill a victim, and Tinker is one of the most subtle heroes in the game
Additional:
* Skywrath Mage stands perfectly on the center line against Tinker, thanks to his nuke and silence. Also, thanks to his abilities, he can quickly kill a victim, and Tinker is one of the most subtle heroes in the game
Nyx Assassin
* Slow-moving projectiles: 
Skywrath Mage, Tinker, 
Necrophos
Additional:
* Skywrath Mage's low health makes him rather easy prey for Nyx Assassin and his lack of armor generally means he'll take the full brunt of a Vendetta strike.
* Mind Flare turns Skywrath Mage's high intelligence growth against him and deals heavy damage.
* Spiked Carapace gives Nyx some degree of protection against Skywrath's spells.
Tinker
* Illusion heroes, such as Naga Siren, Phantom Lancer, Chaos Knight, Terrorblade will become strong against Tinker in the late game. Without Aghanim's Scepter Tinker is forced to defensively disarm heroes with Laser, leaving illusions free to deal physical damage which Tinker's low armor makes highly effective. In addition, Mjollnir or Battle Fury, two common pickups against illusion heroes, don't work well on Tinker at all.
Nyx Assassin
* Nyx Assassin's skillset is mostly single-targeted, therefore he will have difficulties against heroes with illusions and summons: Naga Siren, Broodmother, Lycan, Visage, Phantom Lancer. And to make things worse, Nyx Asassin is not a common Battle Fury, Maelstrom, Mjollnir, Gleipnir or Radiance wielder to counter this problem.
Tinker
* Laser prevents 
Juxtapose from triggering, as it only triggers on successful attacks
* Laser does high splash, and upgrading it with Aghanim's Scepter makes it deal twice as much damage due to the bounce. Combined with Rearm, Tinker can rapidly deplete Phantom Lancer's illusion army
* However, if Phantom Lancer ambushes Tinker, Tinker will not survive versus Phantom Lancer.
Tinker
* All of Tinker's damage is magic/pure and completely ignores Enchantress's 
Untouchable. And Tinker's nukes can quickly decimate her small HP pool, sometimes even preventing Enchantress from even responding.
* As Enchantress relies solely on her primary attacks to deal damage, and rarely builds something to dispel it, Laser's Blind is particularly effective.
* However, Enchantress will probably build a Linken's Sphere against Tinker's Laser, so getting an additional disable is highly recommended.
Nyx Assassin
* Vendetta can deal great damage against her. However, it requires an direct attack, so Nyx Assassin may have difficulties applying Vendetta on her.
* Enchantress's lack of mobility makes her a primary target for ganking with Vendetta.
* Mind Flare can deal a great damage against her due to being an Intelligence hero.
* Spiked Carapace can reflect Impetus and stun Enchantress.
Additional:
* Spiked Carapace reflects the damage from 
Impetus.
* Enchantress is a rather squishy hero, making her fall easily to Nyx Assassin's high burst damage.
Tinker
* Tinker is one of the few characters in Dota 2 who is able to defeat a Sniper on the center line – Tinker. On the center line, he gains an advantage over his opponent, and later acquires additional control. It is these abilities that the enemy should have in the game against the Sniper.
Additional:
* Tinker is one of the few characters in Dota 2 who is able to defeat a Sniper on the center line – Tinker. On the center line, he gains an advantage over his opponent, and later acquires additional control. It is these abilities that the enemy should have in the game against the Sniper.
Nyx Assassin
* 
Assassinate is easy to reflect with Spiked Carapace for massive damage.
* 
Shrapnel's area damage can set up an easy stun with Spiked Carapace, especially when combined with Vendetta.
* In the early game, Sniper's low health pool and high intelligence makes him easy prey for Nyx Assassin.
Tinker
* Laser along with Heat-Seeking Missile allows Tinker to quickly burst down Drow Ranger due to her low health.
* Heat-Seeking Missile lets Tinker out-range Drow Ranger and hit her in the backline of a teamfight.
Nyx Assassin
* Nyx Assassin has a lot of burst damage from his Impale, Mind Flare, 
Dagon, and the bonus damage from Vendetta. All of this damage is enough to kill Drow Ranger.
* Nyx Assassin is usually invisible most of the time thanks to his ability Vendetta, which allows him to gank Drow Ranger easily.
Tinker
* Tinker can use Laser to save an ally or himself from Phantom Assassin's initiate 
Phantom Strike due to the blind, forcing her to use a Black King Bar to effectively initiate, Tinker can also use Warp Flare one he buys Aghanim's Shard to reverse Phantom Strike's blinking with Phantom Strike.
* Tinker almost never uses his physical attack, relying on his spell-spamming to deal damage which ignores 
Blur's Evasion
* Defense Matrix prevents 
Coup de Grace from triggering.
Nyx Assassin
* Heroes with heavy early and mid-game magical damage are also problematic for Phantom Assassin due to being able to easily kill her before she can gain an item advantage over them: Lina, Necrophos, Nyx Assassin, 
Gyrocopter.
Tinker
* Any hero with a low HP pool is easy for Tinker to nuke down: 
Crystal Maiden, 
Enchantress, Gyrocopter, 
Lion, Riki, 
Techies, Terrorblade, Necrophos, Invoker.
Nyx Assassin
* Crystal Maiden has a very bad movement speed, so Impale is easy to land against her. Furthermore, even while trapped by Frostbite, Nyx Assassin can still cast Impale.
* Crystal Maiden has very low armor, so Vendetta is very effective.
* Nyx Assassin has two ways to stop Freezing Field, provided she doesn't get a Black King Bar. He can either pop Spiked Carapace and simply walk into the field, or he can use Impale to interrupt the field, since Crystal Maiden has to channel it.
Additional:
* Spiked Carapace easily interrupts 
Freezing Field.
* 
Frostbite's damage over time sets up an easy Spiked Carapace stun.
* Crystal Maiden is extremely fragile and dies quickly to Nyx Assassin's burst damage.
Tinker
* Since Windranger is bad against magical damage, heroes with continuous magical damage or magical nukes can blast her: 
Zeus, Tinker, 
Leshrac, 
Viper, Skywrath Mage, Lion, Lina, Venomancer.
Nyx Assassin
* Many of Nyx Assassin's abilities are good against Windranger.
* Impale is great for stunning Windranger and allowing additional disables to be landed.
* Mind Flare is useful against Windranger's decent intelligence growth.
* Spiked Carapace is easy to use against Powershot.
* Vendetta allows Nyx Assassin to sneak up on and deal massive damage to Windranger without giving Windranger a chance to use Windrun to evade it.
* Nyx Assassin's item build allows him to easily deal with Windranger.
Tinker
* The blind from Laser prevents Shadow Fiend from attacking for its duration, potentially preventing him from getting a kill.
* Scythe of Vyse can be used to prevent Shadow Fiend from casting Requiem of Souls.
* A combination of Tinker's abilities and his items (like the 
Dagon 5 and 
Ethereal Blade combo) can kill Shadow Fiend quickly.
Additional:
* During the laning stage Laser will reduce Shadow Fiend's last hits, preventing him from getting 
Necromastery souls.
* Shadow Fiend has low health and is vulnerable to Tinker's high magic burst.
Nyx Assassin
* Large area-of-effect with delay or require channeling: Enigma, Crystal Maiden, Invoker, Shadow Fiend, 
Pugna, Keeper of the Light, Dawnbreaker.
Tinker
* Heroes that commonly attack ethereal units will not have any problems against Muerta's Pierce The Veil: Tinker, Jakiro, Lina, Luna, Pugna or 
Ogre Magi.
Nyx Assassin
* Nyx Assassin's high burst damage, excellent ganking potential and multiple disables pose a threat to Muerta at all stages of the game.
* Mind Flare abuses Muerta's high intelligence to make short work of her low health.
* Spiked Carapace and Vendetta allow Nyx to escape or initiate well against Muerta's low mobility.
* As with most retaliation based abilities, Spiked Carapace can easily take advantage of Gunslinger's stray shots.
Tinker
* Tinker has great map presence because of Keen Conveyance and Rearm, which means he can always teleport and defend towers whenever Nature's Prophet tries to push.
* Laser prevents Nature's Prophet from attacking. Additionally, even with 
Monkey King Bar, Nature's Prophet cannot hit towers and buildings during the effect.
Nyx Assassin
* Heroes with invisibility: (Riki, Clinkz, Nyx Assassin.
Tinker
* Tinker's Laser is useful against Outworld Destroyer, as the blind prevents him from landing Arcane Orbs.
Nyx Assassin
* Outworld Destroyer's high intelligence gain and fragility makes him an easy target for a massive Mana Burn, as well as killing him outwards with Nyx Assassin's high burst damage.
* 
Astral Imprisonment can be easily exploited by Nyx Assassin with his abilities. As long as Astral Imprisonment was not cast on Nyx Assassin, it will make an opportunity for an easy stun, either by Spiked Carapace (if Outworld Destroyer hid his allies or your allies) or Impale (if he hid himself). If Astral Imprisonment was cast on Nyx Assassin, using Spiked Carapace while banished will proc the stun after the disable, since Spike Carapace has a 0 second cast time and Astral Imprisonment deals damage right after the disable ends.
* An ill-timed 
Sanity's Eclipse and/or well timed Spiked Carapace can deal a lot of damage to Outworld Destroyer and stun him, unless Outworld Destroyer used Black King Bar beforehand.
Additional:
* Outworld Destroyer's high intelligence makes him a good target for Mind Flare.
* If timed correctly, Spiked Carapace will return the full damage from Sanity's Eclipse back to Outworld Destroyer. Even a reflected Arcane Orb can deal significant damage and make him vulnerable to a follow-up from Nyx Assassin.
* Spiked Carapace is also the perfect tool against Astral Imprisonment: if used on Nyx, he can reflect the damage back as he comes out of the prison by casting the ability while imprisoned.
Tinker
* Any hero with a low HP pool is easy for Tinker to nuke down: Crystal Maiden, Enchantress, Gyrocopter, Lion, Riki, Techies, Terrorblade, Necrophos, Invoker.
Nyx Assassin
* The huge physical damage taken from Vendetta will force Necrophos to use Ghost Shroud, which is good for a followup with Dagon and Ethereal Blade, both of which are common items on Nyx Assassin.
* Using Ghost Shroud also sets Necrophos up for a Mind Flare or Impale.
Tinker
* Illusion heroes, such as Naga Siren, Phantom Lancer, Chaos Knight, Terrorblade will become strong against Tinker in the late game. Without Aghanim's Scepter Tinker is forced to defensively disarm heroes with Laser, leaving illusions free to deal physical damage which Tinker's low armor makes highly effective. In addition, Mjollnir or Battle Fury, two common pickups against illusion heroes, don't work well on Tinker at all.
Tinker
* An Aghanim's Scepter upgraded Laser allows Tinker to blind Terrorblade and his illusions.
* Tinker deals incredible amounts of pure and magical damage with Laser and Heat-Seeking Missile combined with Rearm, which will ignore Terrorblade's armor and be devastating to his low health pool.
* Tinker is a hero who very often goes for Blink Dagger, and because Terrorblade has no disable to lock down Tinker, he will be unable to catch up with him nor to prevent him from escaping with Boots of Travel.
Additional:
* Tinker can single-handedly stop Terrorblade's early-push and quickly clear his illusions with Laser (especially with Aghanim's Scepter).
* Tinker has perfect tools to reveal Terrorblade from his illusions as well as to burst him down if he is low-health before he will be able 
Sunder.
Nyx Assassin
* Nyx Assassin deals large amounts of pure damage with Vendetta and magical damage with Impale and Mind Flare, allowing him to ignore Terrorblade's armor and burst his low health pool down before he can use Sunder.
* Nyx Assassin commonly buys 
Urn of Shadows, Dagon and 
Meteor Hammer which deal magic damage that ignore Terrorblade's armor.
Tinker
* Heroes with either magical, physical or pure damage burst: Bane, Ember Spirit, Leshrac, Lina, Luna, Nyx Assassin, Phantom Assassin, Skywrath Mage, Tinker, 
Ursa, 
Void Spirit.
Nyx Assassin
* Heroes with either magical, physical or pure damage burst: Bane, Ember Spirit, Leshrac, Lina, Luna, Nyx Assassin, Phantom Assassin, Skywrath Mage, Tinker, Ursa, Void Spirit.
Tinker
* Heroes with either magical, physical or pure damage burst: Bane, Ember Spirit, Leshrac, Lina, Luna, Nyx Assassin, Phantom Assassin, Skywrath Mage, Tinker, Ursa, Void Spirit.
Nyx Assassin
* Heroes with either magical, physical or pure damage burst can often kill Chen or his allies before he can use Hand of God: Lina, Luna, Techies, Shadow Fiend, Pugna, Nyx Assassin.
Nyx Assassin
* Spiked Carapace stops Snapfire's 
Mortimer Kisses.
Nyx Assassin
* Vendetta burns a significant amount of mana on hit, and the damage from the ability drains Medusa's mana pool even further.
* Due to the passive nature of Mystic Snake and Split Shot, it can possibly proc Nyx's Spiked Carapace if he's within range of Medusa's abilities and isn't invisible.
* Medusa lacks single target damage, making Nyx with Aghanim's Scepter extremely hard to deal with if Medusa is the team's main damage source.
Additional:
* With her passive 
Split Shot, Medusa can be easily interrupted by Spiked Carapace during combat, especially during her precious 
Stone Gaze.
* Mana Burn quickly destroys 
Mana Shield, especially if Medusa only increases her mana pool by bolstering intelligence (which has the added bonus of increasing Mana Burn's damage).
* Uncontrollable damage from 
Mystic Snake and Split Shot can trigger Spiked Carapace.
* 
Medusa lacks single target damage, making a Burrowed Nyx Assassin hard to kill.
Nyx Assassin
* Ravage's travel time allows Nyx Assassin to easily stun Tidehunter with Spiked Carapace.
* Vendetta can instantly deplete Tidehunter's low mana pool, especially in the early game, potentially preventing Tidehunter from casting Ravage.
Nyx Assassin
* Nyx Assassin's high burst damage can be the bane of Dark Willow, as her low health makes it difficult to survive long enough to escape through Shadow Realm.
* Spiked Carapace can be triggered by walking deliberately into Bramble Maze, leaving Dark Willow stunned and defenseless.
Tinker
* Tinker can break Magnus's Blink Dagger using 
March of the Machines and Heat-Seeking Missile, therefore delaying any initiation or making Magnus use Skewer or 
Force Staff to initiate. His {Ability ID:Defense Matrix|Tinker} will decrease the duration of Reverse Polarity and can also be cast on all of his teammates with {Ability ID:Rearm|Tinker}. Tinker usually gets his own Blink Dagger as well, which makes him harder to lock down unless Magnus commits Reverse Polarity only for Tinker.
Nyx Assassin
* Spiked Carapace can be used to reflect Illuminate damage and stun Keeper of the Light.
* Vendetta allows Nyx Assassin to follow Keeper of the Light around if he tries to split-push.
* Keeper of the Light is very squishy and will very quickly die to Vendetta and it's followup abilities.
Tinker
* Laser can be cast on a initiating Ursa, normally causing him to waste multiple 
Overpower attacks, forcing him to either Black King's Bar, or 
Enrage to protect himself.
* Ursa will probably carry a Linken's Sphere to counter Tinker's Laser. Popping it with Scythe of Vyse is actually preferable, due to Laser's high Pure damage.
* While Ursa is a common Blink Dagger carrier, but he otherwise has no way to close the gap, Baiting him into using his Blink, then blinking away, allows Tinkrt to easily kite Ursa.
* Enrage is generally how Ursa disengages, Due to Tinker's high maneuverability, he can follow him until it runs out. then burst him down with high magic damage.
Nyx Assassin
* Nyx's Spiked Carapace can reflect the damage of 
Sharpshooter, instantly killing hoodwink. Nyx can also use Vendetta to position himself in such a way to screen allies from Sharpshooter and catch Hoodwink by surprise.
Nyx Assassin
* A good Nyx can reflect Queen of Pain's Sonic Wave with his Spiked Carapace, or even initiate a gank on her in Vendetta while she farms a creep wave with Scream of Pain.
* Her strength to intelligence ratio is bad enough that he should be able to kill her without even requiring a Dagon, provided he can get his full combo off.
Nyx Assassin
* Spiked Carapace allows Nyx to get an easy long-duration stun on Weaver once he uses Shukuchi, and then he can follow up with Impale.
* Vendetta works as a great setup for both Impale and Spiked Carapace and can deal decent damage to Weaver. Additionally he can neutralize The Swarm beetles due to his invisibility duration.
Nyx Assassin
* Nyx Assassin's Spiked Carapace will stun Leshrac when hit by any of his AOE abilities.
* Mind Flare deals high damage due to Leshrac's high intelligence gain.
* Vendetta burns a large amount of Leshrac's essential mana pool.
Nyx Assassin
* Spiked Carapace reacts on any of the damage over time from Phoenix's abilities and can interrupt 
Sun Ray and 
Icarus Dive.
Nyx Assassin
* Impale and Spiked Carapace interrupts Upheaval with ease.
* Warlock's low health pool, mobility, and high intelligence gain makes him a prime target for Nyx Assassin's burst damage.
Tinker
* All of his damage is magical and pure, which makes Cold Embrace a good setup for his nukes.
* Winter's Curse is very hard to cast on Tinker because he usually stays in the back-lines in team-fights. In turn, Tinker has mediocre attack damage and will contribute very little when he is cursed to attack an ally. He can also save his ally under Winter's Curse effect with Ethereal Blade and Defense Matrix.
Tinker
* Laser blinds Lone Druid, making his attacks miss.
Tinker
* Heroes with high magical or pure damage will bypass Bulwark: Timbersaw, 
Dark Willow, Enigma, Invoker, Pugna, Skywrath Mage, Tinker, Zeus, 
Oracle.
Tinker
* Heroes with Evasion or abilities that cause Tiny to miss like Phantom Assassin and Tinker are very effective because of Tiny's low attack speed. Additionally, Monkey King Bar is not a good item for Tiny because of its reliance on high attack speed to proc for magical damage.
Tinker
* Heroes who rely on abilities to deal damage (e.g. Timbersaw, Tinker) can fight a Razor even after Static Link.
Tinker
* Lion has an incredibly fragile health pool, making him weak against nukers like Tinker or Oracle.
Tinker
* Heroes with wide AoE abilities will reveal Monkey King through Mischief: Necrophos, 
Phoenix, Alchemist, 
Earthshaker, 
Razor, Tinker, Leshrac, 
Queen of Pain
Nyx Assassin
* Heroes that can pick you off: Clinkz, Nyx Assassin, 
Puck, Riki.
Tinker
* Tinker is relatively helpless against Invoker, as his Rearm and Boots of Travel can be easily interrupted by Invoker's long range disables, even if he blinks away.
Tinker
* Any hero with a low HP pool is easy for Tinker to nuke down: Crystal Maiden, Enchantress, Gyrocopter, Lion, Riki, Techies, Terrorblade, Necrophos, Invoker.
Nyx Assassin
* Nyx Assassin can simply activate Spiked Carapace while under many Invoker's abilities to stun him.
* Nyx Assassin takes advantage of Invoker's massive intelligence gain to do tons of damage using Mind Flare, as the spell does more damage based on the target's intelligence.
* Vendetta burns a large amount of Invoker's essential mana pool.
Tinker
* Any hero with a low HP pool is easy for Tinker to nuke down: Crystal Maiden, Enchantress, Gyrocopter, Lion, Riki, Techies, Terrorblade, Necrophos, Invoker.
Nyx Assassin
* Heroes who can drain mana can make Omniknight useless after he uses one or two abilities: Lion, 
Anti-Mage, Nyx Assassin.
Tinker
* Heroes with powerful spammable abilities will prove problematic for Grimstroke as Ink Swell does not protect him from them: Zeus, Skywrath Mage, Tinker, Lina
Nyx Assassin
* Heroes with silence and mana drain abilites, as Ancient Apparition relies entirely on his abilities: Invoker, 
Silencer, Nyx Assassin, Skywrath Mage, 
Shadow Shaman, Lion and etc.
Nyx Assassin
* Nyx Assassin, Bounty Hunter and Slark can all sneak up and kill Shadow Shaman, Nyx being particularly deadly. Shadow Shaman must watch out for Slark carefully, as he can break either (but not both unless he makes a mistake) of Shadow Shaman's disables, with Dark Pact and leap out of a serpent ward ring. These heroes, however, rely heavily on escape and are themselves not very durable and none of them can survive a full lockdown with Mass Serpent Ward. Having Sentry Wards can turn Shadow Shaman from prey to predator.
Tinker
* Any hero with a low HP pool is easy for Tinker to nuke down: Crystal Maiden, Enchantress, Gyrocopter, Lion, Riki, Techies, Terrorblade, Necrophos, Invoker.
Tinker
* Heroes with high armor like 
Dragon Knight, or with abilities to cause attacks to miss like Phantom Assassin, Riki and Tinker will be hard to deal with, as Clinkz relies almost entirely on physical attacks.
Nyx Assassin
* Heroes who rely on damage over time as Spiked Carapace can block and reflect only one instance of damage: Venomancer, Huskar, Ember Spirit, Dark Seer, Sand King, Doom, Dawnbreaker. However, this also means they are easily stunned.
Tinker
* Heroes who rely on basic attacks will suffer from Laser: Phantom Assassin, Wraith King, Huskar.
Nyx Assassin
* Nyx Assassin can reflect Life Break with Spiked Carapace.
Tinker
* Heroes who rely on basic attacks will suffer from Laser: Phantom Assassin, Wraith King, Huskar.
Tinker
* Heroes that can gain vision over trees to catch Tinker: Invoker, Shadow Demon, Batrider.
Nyx Assassin
* Nyx can walk into Firefly with Spiked Carapace and stun Batrider if he has no Spell Immunity, even if Batrider is focusing on other enemy hero.
Tinker
* Timbersaw's ability to destroy trees can be a serious problem for some heroes that use them, as either a way of enhancing their spells like 
Treant Protector, or heroes that tend to hide inside of them like Tinker and 
Monkey King.
Tinker
* All Tinker's damage is magic/pure and completely ignores Timbersaw's 
Reactive Armor.
* Timbersaw very rarely builds Black King Bar, making him very vulnerable if Tinker builds Scythe of Vyse.
Nyx Assassin
* Heroes who rely on damage over time as Spiked Carapace can block and reflect only one instance of damage: Venomancer, Huskar, Ember Spirit, Dark Seer, Sand King, Doom, Dawnbreaker. However, this also means they are easily stunned.
Nyx Assassin
* With Vendetta, Nyx Assassin can move closely to Ember Spirit when he's farming with his Flame Guard and use Spiked Carapace with Impale to provide a reliable and long disable.
Additional:
* Spiked Carapace can be easily triggered by 
Flame Guard or Battle Fury, setting up a deadly Impale.
Tinker
* Low health spellcasters: Lina, Witch Doctor, Tinker, Keeper of the Light, all rely heavily on their spells and are fragile heroes. They all also have avoidable spells, allowing Puck to get to them and quickly burst them down.
Nyx Assassin
* 
Illusory Orb is easy to reflect with Spiked Carapace, either stunning Puck and setting up an easy Impale or forcing a premature 
Phase Shift.
* Puck is an intelligence hero that tends to build intelligence items, making it vulnerable to Mana Burn.
* An ill-timed Phase Shift can easily set Puck up to be stunned by Impale.
* Puck's low base armor and below average agility gain mean it is always susceptible to Vendetta.
Additional:
* Nyx Assassin can take advantage of every one of Puck's weaknesses. His entire skill set is very effective in countering Puck.
* Because Illusory Orb is such a slow moving projectile, Nyx Assassin can simply walk into the orb and activate Spiked Carapace, stunning Puck and setting up an easy Impale. This can be circumvented by using Phase Shift while the orb is traveling, however, that means that Puck cannot use Phase Shift to dodge any other skill nor use it to safely blink away from a fight.
* Puck is an intelligence hero that likes to build intelligence items such as Eul's Scepter of Divinity, Scythe of Vyse, and Dagon. This makes Mind Flare that much more deadly against Puck.
* An ill-timed Phase Shift can turn into an easy setup for Impale.
Nyx Assassin
* Heroes who rely on damage over time as Spiked Carapace can block and reflect only one instance of damage: Venomancer, Huskar, Ember Spirit, Dark Seer, Sand King, Doom, Dawnbreaker. However, this also means they are easily stunned.
Nyx Assassin
* Spiked Carapace can stop Dawnbreaker's Solar Guardian which will eliminate her global presence and limits her movement around the map.
Additional:
* Spiked Carapace interrupts 
Starbreaker before Dawnbreaker has her Aghanim's Shard, as well as 
Solar Guardian during the initial channel, making her ineffective at joining and dealing damage in teamfights.
* The slow projectile and damage over time effect of 
Celestial Hammer makes it easy to stun Dawnbreaker if she attemps to engage or chase.
Nyx Assassin
* Heroes who build Black King Bar as either core or situational item will be able to fight back against Nyx Assassin and freely attack him as Spiked Carapace cannot pierce spell immunity at all: Axe, Broodmother, Dawnbreaker, Enigma, Huskar, Jakiro, Legion Commander, Lina, Luna, Lycan, Slardar, Slark, Troll Warlord, Witch Doctor.
Nyx Assassin
* Mind Flare does tons of damage against Lina because of her high intelligence.
* The mana burn from Vendetta also prevents Lina from casting her full combo.
* Spiked Carapace can easily be used to counter Lina's abilities because of their long cast animation, and could probably kill Lina outright if Laguna Blade is reflected.
Nyx Assassin
* Heroes with invisibility will be detected by Thirst when they have low enough health: Bounty Hunter, Templar Assassin, Riki, Clinkz, 
Weaver, Treant Protector, Nyx Assassin.
Additional:
* While Burrowing, Nyx is an easy target for a 
Blood Rite, although he can at least partially counter it with a well-timed Spiked Carapace.
* 
Thirst is always a threat to Nyx Assassin, hindering his attempt of escape using Vendetta.
* 
Rupture also prevents Nyx Assassin from escaping with Vendetta, as it forces him to stay still.
Tinker
* Laser blinds Bloodseeker, preventing him from getting last hits and denies during the laning stage and preventing him from finishing off enemies.
* Tinker always buys Boots of Travel, helping him escape Bloodseeker's early ganks.
* Tinker's heavy magical damage will burst down Bloodseeker during the early to mid game, as he has little health.
Additional:
* Laser can be very effective against 
Bloodrage as the damage will be amplified while the blind prevents Bloodseeker from landing hits.
* Keen Conveyance guarantees him escape from Rupture.
Nyx Assassin
* Heroes who rely on invisibility, such as Bounty Hunter, Clinkz, 
Mirana, Nyx Assassin and Riki, as they will be revealed if caught by Chronosphere.
Tinker
* If Tinker can stay outside of 
Chronosphere, Laser can cause Faceless Void to miss all his attacks.
* Faceless Void has low health and strongly relies on 
Time Walk's healing factor to remain alive. Getting caught by Tinker with Scythe of Vyse will almost always spell a quick end for Void.
* Rearm ignores 
Time Dilation completely.
Tinker
* Illusion heroes, such as Naga Siren, Phantom Lancer, Chaos Knight, Terrorblade will become strong against Tinker in the late game. Without Aghanim's Scepter Tinker is forced to defensively disarm heroes with Laser, leaving illusions free to deal physical damage which Tinker's low armor makes highly effective. In addition, Mjollnir or Battle Fury, two common pickups against illusion heroes, don't work well on Tinker at all.
Tinker
* With Aghanim's Scepter, Tinker's Laser completely stops Chaos Knight's damage, forcing him to buy either a Black King Bar for his own survivability while leaving his illusions still vulnerable, or a Monkey King Bar leaving him still vulnerable to Tinker's nukes, though improving his damage.
* Tinker rarely finds himself in the middle of a fight, which is where Chaos Knight typically thrives, and even in the rare cases of being so, at level 3 Tinker's constant rearm and blink away can kite and dodge Chaos Knight's spells reliably, so Chaos Knight has very little catch against Tinker's mobility. This gives Tinker impunity to create more chaos in a teamfight than Chaos Knight can control, laying down the field with March of the Machines and constantly being hit by rockets and lasers.
Nyx Assassin
* Some abilities deals damage from an independent source and not from the hero itself, so Nyx cannot counter them with Spiked Carapace: illusions or summoning units, 
Homing Missile, Nimbus, 
Mass Serpent Ward, 
Death Ward and especially Techies's mines.
Tinker
* Any hero with a low HP pool is easy for Tinker to nuke down: Crystal Maiden, Enchantress, Gyrocopter, Lion, Riki, Techies, Terrorblade, Necrophos, Invoker.
Tinker
* Storm Spirit destroys trees and ignores impassable terrains with 
Ball Lightning, rendering them dangerous places for Tinker to hide within.
* Ball Lightning disjoints projectile from Heat-Seeking Missile and damage from March of the Machines.
* 
Electric Vortex prevents Tinker from teleporting away, and 
Static Remnant and 
Overload can easily burst him down.
Additional:
* He can easily catch Tinker in the trees with Ball Lightning and kill him with 
Orchid Malevolence and his abilities, which deal both physical and magical damage, making them difficult for Tinker to itemize against.
Nyx Assassin
* Mana Burn removes much-needed mana for Ball Lightning.
* Spiked Carapace triggers on Static Remnant for an easy stun.
Additional:
* Vendetta is capable of removing most of Storm Spirit's large mana pool, along with dealing heavy damage and quickly depleting his chances of escaping a gank or fight.
Nyx Assassin
* Heroes who build Black King Bar as either core or situational item will be able to fight back against Nyx Assassin and freely attack him as Spiked Carapace cannot pierce spell immunity at all: Axe, Broodmother, Dawnbreaker, Enigma, Huskar, Jakiro, Legion Commander, Lina, Luna, Lycan, Slardar, Slark, Troll Warlord, Witch Doctor.
Nyx Assassin
* Enigma is fragile, and lacks escapes, being dependent on Blink Dagger for mobility. Ganking Heroes or Heroes with burst damage will likely kill him before he can do anything. Such Heroes include: Lina, Lion, Luna, Puck, Slark, Nyx Assassin, etc.
Additional:
* Enigma's uncontrollable damage from 
Malefice and 
Midnight Pulse make him easy to stun with Spiked Carapace.
* 
Black Hole can be easily interrupted by Impale or Spiked Carapace.
Tinker
* Meat Hook can be used to pull Tinker to Pudge while he is hiding in the trees, and a follow up with Dismember and Rot can lead to a valuable kill, as Tinker doesn't buy many survivability items.
* Flesh Heap makes it hard for Tinker to deal serious damage.
Additional:
* Pudge can 
Meat Hook a Tinker hiding in the trees and follow it up with 
Dismember and 
Rot for an easy solo kill, as Tinker doesn't tend to buy survivability items.
* Many stacks of 
Flesh Heap combined with items that give Pudge high strength and health will make it hard for Tinker to deal serious damage to Pudge.
Nyx Assassin
* Impale and Spiked Carapace can be used to cancel Dismember easily, and can even do so when Pudge uses it on Nyx Assassin, if timed correctly.
Nyx Assassin
* 
Corrosive Skin minimizes the damage from Impale and Mind Flare.
* Nyx Assassin cannot survive several poison damage-over-time, even Spiked Carapace is activated.
Tinker
* Viper is kind of a mixed package. Tinker is very good against him. but stands a better chance against him than most heroes.
* Viper has a high innate magic resistance, but relies on his primary attacks to really deal damage. making Laser an effective way to save allies from him, and deal damage. Keep in mind that his Corrosive Skin will prevent Tinker from blinking.
* Viper's 
Viper Strike and 
Poison Attack will also have a hard time damaging allies through Tinker's constant casting of Defense Matrix.
* Viper has no solutions to cancel Rearm nor any of Tinker's escape attempts with Boots of Travel
* However, if Viper gets a jump on Tinker first. Tinker will unlikely survive versus Viper.
Tinker
* Heroes with unorthodox escapes will struggle against Primal Beast, such as Nature's Prophet, Tinker, and Templar Assassin.
Nyx Assassin
* Like above, supports with reliable stuns can be a massive problem and force Black King Bar in fights unideally, such as Shadow Shaman, Lion, Nyx Assassin.
Tinker
* Silencer can stop Rearm, preventing Tinker from spamming his abilities/items or escaping.
* Tinker heavily relies on his mana pool and has mana issues throughout the entire game and Silencer's intelligence steal does not help with that.
Additional:
* As Tinker relies heavily on his spells to be effective, 
Last Word and 
Global Silence will render him largely useless.
* 
Arcane Curse effectively prevents Tinker from casting spells during its duration, as he will otherwise suffer heavy damage.
* 
Glaives of Wisdom deal pure damage, which make quick work of fragile heroes like Tinker.
* Silencer's intelligence steal permanently weakens Tinker since he's a hero who requires lots of mana to be effective.
Nyx Assassin
* Last Word is extremely easy to reflect with Spiked Carapace for large amounts damage, due to triggering when Nyx Assassin casts a spell, but can still silence Nyx Assassin. It also has the added bonus of dealing more damage the more Intelligence Silencer has.
* Glaives of Wisdom quickly builds Silencer's Intelligence, making him a particularly prime target for Mana Burn.
* Silencer rarely builds survivability items, nor is he able to steal much Intelligence while surrounded by his team, and so is an excellent target for Vendetta.
* Silencer has no reliable way of dealing with a burrowed Nyx, and also lacks the ability to prevent Nyx from escaping with Vendetta,
Additional:
* Silencer is rather squishy and has poor mobility without items, making him an easy target for Nyx.
* Silencer's intelligence steal ability is a complete disadvantage against Nyx Assassin as Mind Flare will deal increasing damage for each point of intelligence Silencer has stolen, turning Silencer's intelligence steal against him.
Tinker
* 
Wave of Terror can reveal a Tinker attempting to hide in the trees and then 
Nether Swap and 
Magic Missile will both serve to interrupt/lock him down, should he attempt to town portal or reload.
Nyx Assassin
* Vendetta disables Vengeance Aura and allows him to attack Vengeful Spirit with Impale and Mind Flare.
* Spiked Carapace is easy to use against a Wave of Terror or Magic Missile.
Tinker
* 
Nether Ward discourages Tinker from using abilities and items due to its high damage against heavy mana usage.
Nyx Assassin
* 
Nether Blast's animation makes it easy to time Spiked Carapace for a stun.
* Pugna has the largest intelligence gain in the game, making him a prime target for Mana Burn.
* Pugna needs to channel 
Life Drain, making him easy to hit with Impale.
Additional:
* Due to Pugna's incredible intelligence growth and terrible strength growth, Nyx should always be able to take you out with his combo, with or without an added Dagon. Mind Flare will deal a large amount of damage in particular, especially in the late game.
* Spiked Carapace is also a great tool versus Pugna. A good player will wait for you in Vendetta until you farm a creep wave with Nether Blast and reflect it back at you as their initiation and setup for Impale.
Tinker
* Lifestealer's Rage makes him immune to all of Tinker's damage and debuffs.
Rage will dispel Laser's blind and turns him spell immune for the duration so Tinker cannot damage him.
Feast will quickly bring down Tinker due to being so fragile.
* Lifestealer can infest a mobile ally (teams usually pick one against Tinker), which may ensure that Tinker will die if he is caught.
Additional:
*
*
Nyx Assassin
* Like with Juggernaut's
Blade Fury, 
Rage allows Lifestealer to freely attack Nyx Assassin and hunt him down if Vendetta is on cooldown. Nyx Assassin cannot counter 
Rage with Spiked Carapace because 
Rage gives Lifestealer spell immunity. And besides Vendetta, Nyx Assassin has no other way of dealing damage to Lifestealer while he is spell immune.
Open Wounds from 
Aghanim's Shard allows Lifestealer to severely slow down Nyx Assassin while also allowing his team to recover themselves while attacking Nyx Assassin. 
Open Wounds can also fester and spread if Nyx Assassin takes enough damage that will trigger the spread while he is affected with 
Open Wounds.
Infest combined with an ancient creep makes Nyx Assassin an easy target to surprise with 
Dust of Appearance or a 
Gem of True Sight. And similarly to Juggernaut's 
Omnislash and 
Swiftslash from 
Aghanim's Scepter, 
Aghanim's Scepter upgraded 
Infest can also allow Lifestealer to infest, disarm and freely attack Nyx Assassin from within. and Nyx Assassin cannot counter this with Spiked Carapace because Lifestealer is invulnerable while attacking the infested enemy hero from within.
*
*
* Like with Juggernaut, any attempt for Nyx Assassin to gank and kill Lifestealer will hurt Nyx Assassin more than Lifestealer.