Tiny
* 
Reaper's Scythe will turn Tiny's high health against him.
* 
Heartstopper Aura does substantial damage to Tiny as a result of his high max health.
* 
Ghost Shroud protects Necrophos from Tiny's physical damage with Tree Grab and Tree Volley.
Bristleback
* Reaper's Scythe and Heartstopper Aura deal percentage-based damage, ignoring Bristleback's high health.
* Heartstopper Aura's HP removal does not trigger Bristleback's passive.
Additional:
* Heartstopper Aura deals percentage-based damage flagged as HP removal, so it is not reduced by 
Bristleback, nor does it trigger passive 
Quill Sprays.
* Reaper's Scythe is very effective against Bristleback not only due to its percentage-based damage, but rather because it first stuns and then deals its damage, allowing Necrophos to position in front of Bristleback in time.
Bristleback
* Enemies that possess high defenses through magic resistance, damage reduction, or high regeneration will make it difficult to whittle their health down to get to Reaper's Scythe's threshold. Such heroes include 
Bristleback (although only from behind), 
Spectre, 
Ursa, and 
Dragon Knight.
Tiny
* Heroes that are able to slow Tiny's attack speed, like 
Tusk and 
Phoenix, will greatly limit his Physical damage output.
Bristleback
* Heroes with high health especially Strength heroes will take more damage on Sun Ray: 
Axe, 
Pudge, Bristleback, 
Mars.
Tiny
* Heroes with high base damage (
Morphling, 
Tiny, 
Drow Ranger), heroes with mana burning abilities (
Anti-Mage), and 
Diffusal Blade users (
Juggernaut or 
Riki) will suffer from Reflection's illusions.
Bristleback
* 
Terrorblade's 
Sunder is not affected by the Bristleback damage reduction.
Tiny
* 
Avalanche and 
Toss will never be enough damage to take out Sven in a clean way.
* Tiny is very slow with low armour growth and does not buy items to sustain Sven's damage output.
Bristleback
* 
Duel makes Bristleback fight Legion Commander face to face, forcing him to take full damage.
* 
Press the Attack dispels the slow from stacks of Viscous Nasal Goo.
Additional:
* When dueled, Bristleback will have to face Legion head on, not allowing his passive Bristleback to come into effect.
Bristleback
* Outworld Destroyer's high burst damage is not negated by Bristleback's passive. So, even if Bristleback turns his back on Outworld, he can decimate Bristleback quickly.
* If Bristleback attempts to flee, or tries to close the gap, Outworld can banish him with 
Astral Imprisonment, both reducing Bristlebacks much needed mana and allowing Outworld to move in front of him, forcing him to take the full damage from his spells. This will also allow Outworld to land a devasting Sanity's Eclipse, without it being reduced by Bristleback's passive.
Bristleback
* Undying's Decay is a dangerous ability against Bristleback, as it makes him more vulnerable and reduces his tankiness.
* Undying's Tombstone together with Flesh Golem can slow Bristleback down significantly.
Bristleback
* 
Shukuchi gets Weaver in front of Bristleback, negating the protection from Bristleback.
* Weaver's mana break talent depletes Bristleback's mana pool, preventing him from spamming abilities.
Tiny
* 
Blade Fury protects Juggernaut from all of Tiny's magic burst damage.
Tiny
* Dual Breath and Liquid Fire reduces Tiny's already abysmal Attack Speed.
* If Tiny Tosses a hero onto Jakiro, he can react with Ice Path, and potentially Macropyre.
* Tiny's Avalanche is easily countered with Ice Path.
* As Tiny has a very high Health, Liquid Frost is particularly effective against him.
Bristleback
* While Jakiro's damage is going to be little more then average against him due to his Bristleback. His large quantity of stuns can prevent Bristleback from getting his much needed 
Warpath stacks, while also giving his allies a chance to counter his high defense.
* Dual Breath and Liquid Frost both reduce Movement Speed, removing one of Bristlebacks greatest strengths.
* Liquid Fire reduces Bristlebacks Attack Speed, making it harder for him to burst down a hero with Warpath.
* However Bristleback can generally catch and kill a lone Jakiro. And Jakiro is only effective in a group.
Bristleback
* 
Macropyre's frequent damage ticks causes Bristleback to activate repeatedly, resulting in free damage as long as Bristleback faces away from Jakiro.
Bristleback
* 
Eye of the Storm melts Bristleback's armor, and makes him much less tanky.
* 
Static Link can completely drain Bristleback's bonus damage from Warpath.
* 
Storm Surge allows Razor to outdistance Bristleback, even with a few stacks of Viscous Nasal Goo on him. Also, if Razor has his Shard, it will deal full damage to Bristleback every time he uses Viscous Nasal Goo (as Bristleback will face him to cast it).
Additional:
* Eye of the Storm melts Bristleback's armor, and makes him much less tanky.
* Static Link can completely drain Bristleback's bonus damage from Warpath.
Bristleback
* 
Arcane Curse stacks every time Bristleback uses an ability, forcing him to stop spamming his abilities, or take heavy health degeneration.
* 
Glaives of Wisdom steals intelligence both permanently and temporarily, causing mana issues for Bristleback.
* 
Last Word and 
Global Silence stops Bristleback from using his abilities altogether.
Additional:
* Bristleback will not be able to cast 
Viscous Nasal Goo or Quill Spray while silenced, effectively blocking a major part of the hero's damage and preventing Warpath charges from stacking.
* Arcane Curse slows Bristleback down and lasts longer the more abilities he uses. On the other hand, if he doesn't use any abilities, he will begin to lose Warpath charges.
Bristleback
* 
Whirling Death deals damage while also reducing {Show:A|Timbersaw|Whirling Death|value4} of Bristleback's strength, making him less tanky.
* 
Reactive Armor can sustain through multiple Viscous Nasal Goo and Quill Spray stacks.
* 
Timber Chain makes it hard for Bristleback to slow down Timbersaw even with Viscous Nasal Goo.
Bristleback
* 
Time Dilation prevents Bristleback from spamming his low-cooldown abilities, greatly reducing his damage and effectiveness.
* 
Chronosphere allows allies to reposition and hit Bristleback from the front, bypassing his defensive bonus from behind.
* Bristleback has no way to prevent Void from using 
Time Walk.
Additional:
* Time Dilation while Quill Spray and Viscous Nasal Goo are on cooldown will make these abilities unusable for a long time, rendering Bristleback nearly useless.
* Bristleback cannot turn inside the Chronosphere, which makes it easy to attack him from the front, completely bypassing his passive damage reduction.
Bristleback
* Mana Break quickly eats away at Bristleback's small mana pool, preventing him from spamming Viscous Nasal Goo and Quill Sprays.
* Bristleback has no innate mobility. Bristleback is easily kited by Blink, ignoring the protection from Bristleback.
Additional:
* 
Mana Break removes both a percentage and flat amount of your mana, preventing Bristleback from using abilities in the lane.
* 
Blink Anti-Mage has very high mobility with this skill, and can easily escape from Bristleback since he has no way to prevent his blink. He can also use this offensively to get in front of Bristleback during fights.
Bristleback
* 
Guardian Sprint allows Slardar to outrun Bristleback, even when slowed by Viscous Nasal Goo.
* 
Corrosive Haze's armor reduction makes Bristleback much less tanky.
Bristleback
* 
Sharpshooter deals massive damage to Bristleback and applies a high duration disable on his passive.
* 
Bushwhack and 
Scurry can be used to easily kite Bristleback.
Additional:
* Bristleback and Warpath can be disabled by Hoodwink's Sharpshooter ability for a long period of time, reducing his both offense and defense.
* Scurry and Bushwhack can be used to kite bristleback.
Tiny
* Invoker is a big problem for Tiny the whole game because of its multiple disables. For example, the 
Cold Snap ability can catch an attack from Tiny's hand by surprise, because it becomes slower with the pumping of 
Grow. has a giant deceleration, creating a condition for the kite, which Tiny is very afraid of. In addition, Invoker has a 
Deafening Blast that disables Tiny's main weapon - strong blows from the hand
Additional:
* Invoker is a big problem for Tiny the whole game because of its multiple disables. For example, such as 
Tornado + 
E.M.P. create unrealistic conditions for Tiny with mana, which is very necessary for Tiny at least for some attacks in a fight. The Cold Snap ability can catch an attack from Tiny's hand by surprise, because it becomes slower with the pumping of Grow. has a giant deceleration, creating a condition for the kite, which Tiny is very afraid of. In addition, Invoker has a Deafening Blast that disables Tiny's main weapon - strong blows from the hand
Bristleback
* 
Phantom's Embrace silences Viscous Nasal Goo and Quill Spray.
* 
Ink Swell stuns Bristleback and gets allies in position faster with increased movement speed to attack his front, countering his passive ability.
Bristleback
* 
Infernal Blade deals scaling damage and is useful against high health targets such as Bristleback.
* 
Doom disables Bristleback's low cooldown abilities, preventing him from triggering Warpath. With his upgraded level 25 talent, it also breaks Bristleback's passive, rendering him more vulnerable.
Additional:
* Infernal Blade deals scaling damage and is useful against high HP targets such as Bristleback.
* Doom prevents Bristleback from casting his two low cooldown abilities, which then prevents him from utilizing Warpath.
* If Doom chooses the Level 25 talent {ValueColor:1|Doom applies Break|25tal} {Symbol:Talent}, he can disable Bristleback and Warpath, taking away much of his durability and damage potential in team fights.
Tiny
* Primal Roar and the slow from Boars make kiting Tiny very easy.
Tiny
* Heroes with Evasion or abilities that cause Tiny to miss like 
Phantom Assassin and 
Tinker are very effective because of Tiny's low attack speed. Additionally, 
Monkey King Bar is not a good item for Tiny because of its reliance on high attack speed to proc for magical damage.
Tiny
* Due to Tiny's non-existent agility gain, high physical damage heroes are more effective against him (
Clinkz, 
Templar Assassin, Ursa, 
Wraith King etc).
Tiny
* Heroes without blink mechanisms or spell immunity will have a hard time positioning against 
Pit of Malice: 
Sven, Tiny, Wraith King, Dragon Knight, 
Meepo, 
Doom, 
Bounty Hunter, 
Dark Seer, 
Undying, 
Alchemist, 
Legion Commander.
Tiny
* Due to Tiny's non-existent agility gain, high physical damage heroes are more effective against him (Clinkz, Templar Assassin, Ursa, Wraith King etc).
Tiny
* Due to Tiny's non-existent agility gain, high physical damage heroes are more effective against him (Clinkz, Templar Assassin, Ursa, Wraith King etc).
Bristleback
* 
Shadow Demon's 
Demonic Purge with 
Aghanim's Scepter disables Bristleback's passives.
Tiny
* He can quickly take out heroes with low armor (Tiny) with his great physical damage.
Tiny
* Heroes with Evasion or abilities that cause Tiny to miss like Phantom Assassin and Tinker are very effective because of Tiny's low attack speed. Additionally, Monkey King Bar is not a good item for Tiny because of its reliance on high attack speed to proc for magical damage.
Tiny
* Long ranged heroes like 
Sniper or Drow Ranger can kite Tiny effectively if he doesn't get the jump on them first.
Tiny
* 
Mana Drain has an fair long range and low cooldown. It can easily deplete most heroes of their entire mana pools, especially those with smaller mana pools such as Tiny or 
Spirit Breaker.
Additional:
* Lion can continuously Mana Drain Tiny in the early game, depleting his small mana pool for his abilities.
Bristleback
* 
Lion's Mana Drain is a headache for Bristleback to deal with during the laning stage, as it denies him the ability to get last hits with Quill Spray.
Tiny
* Squishy heroes, usually supports, like Lion, 
Ancient Apparition, 
Keeper of the Light etc can die quickly to Tiny's magic burst.
Tiny
* Long ranged heroes like Sniper or Drow Ranger can kite Tiny effectively if he doesn't get the jump on them first.
Tiny
* Heroes that are able to slow Tiny's attack speed, like Tusk and Phoenix, will greatly limit his Physical damage output.
Bristleback
* 
Batrider's turn rate slow from 
Sticky Napalm makes it harder for Bristleback to keep his back towards the enemy.
Tiny
* 
Feast will deal a enormous amount of damage because of Tiny's huge health pool.
* 
Rage protects Lifestealer from Tiny's magical burst damage.
Bristleback
* Heroes with high physical damage can damage Lifestealer more than he can heal: Bristleback, Clinkz, 
Luna,
Shadow Fiend, 
Slardar, Terrorblade
Tiny
* Tiny can quickly clear Spiderlings with his active abilities and cleave.
Bristleback
* Quill Spray destroys spiderlings, and hits Broodmother even when she's regenerating in her webs. This makes Bristleback one of her hardest counters in lane.
Additional:
* Bristleback reduces most of Broodmother's and her spiderlings' damage.
* Quill Spray will hit any spiders in its proximity, hindering Broodmother's fighting and farming capabilities.
Tiny
* Tiny can be a serious problem for the distance between Lone Druid and his 
Summon Spirit Bear with his Toss ability, since he will throw one away from the other, giving his team the opportunity to deal with either the Summon Spirit Bear or Lone Druid himself
* Lone Druid will not always be in his 
True Form, since she has her own recharge, which is why Tiny can find him with a 
Shadow Blade or 
Blink Dagger and kill him in a second with a combination of Avalanche and Toss, due to the fact that Lone Druid has a very small health reserve without True Form
Additional:
* Tiny can be a serious problem for the distance between Lone Druid and his Summon Spirit Bear with his Toss ability, since he will throw one away from the other, giving his team the opportunity to deal with either the Summon Spirit Bear or Lone Druid himself
* Lone Druid will not always be in his True Form, since she has her own recharge, which is why Tiny can find him with a Shadow Blade or Blink Dagger and kill him in a second with a combination of Avalanche and Toss, due to the fact that Lone Druid has a very small health reserve without True Form
Bristleback
* Lone Druid and The Spirit Bear cannot burst down Bristleback due to Bristleback
* Bristleback can easily run to Lone Druid without any hesitation, with Viscous Nasal Goo to reduce armor and slow the Spirit Bear or Lone Druid and Quill Spray can deal damage to both Lone Druid and the Spirit Bear at the same time
Tiny
* Tiny's Avalanche affects all Meepos and Toss can send a singular Meepo into death.
Additional:
* Avalanche and Toss prevents Meepo's from using 
Poof to escape.
* Tiny doesn't need to target the weakest clone while he is affected by Tree Grab.
Bristleback
* Quill Spray usually hits Meepo's clones, although Bristleback cannot turn his back when rooted with 
Earthbind.
Bristleback
* Bristleback's tankiness and damage reduction from the rear makes him very hard for Phantom Lancer to chase and finish off, due to his lack of burst damage.
* Quill Spray quickly destroys Phantom Lancer's illusions.
* Bristleback's passive costs no mana, meaning that it will continue to trigger even if Phantom Lancer drains Bristleback's mana with Diffusal Blade.
Additional:
* Bristleback's tankiness and damage reduction from the rear makes him very hard for Phantom Lancer to chase and finish off, due to his lack of burst damage.
* Quill Spray destroys Phantom Lancer's illusions.
* Bristleback's passive costs no mana, meaning that it will continue to trigger even if Phantom Lancer drains Bristleback's mana with Diffusal Blade.
Tiny
* Avalanche and Toss combo makes short work of 
Mirror Image's illusions.
* Tiny's cleave with Tree Grab and area of effect damage with Tree Volley will easily wipe out illusions.
Bristleback
* Viscous Nasal Goo slows down Dragon Knight and lowers armor, locking him down and making him more vulnerable.
Bristleback
* Viscous Nasal Goo can hinder Crystal Maiden's already abysmal mobility, which allows Bristleback (or his teammates) to run her down and kill her.
* Bristleback frequently builds 
Blade Mail, which can quickly kill Crystal Maiden if her ultimate is used while he is under its effect.
* The passive part of Bristleback will trigger many, many times under the damage from Freezing Field, and as the stacks increase, the damage output from each successive cast (or proc) will eat away at Crystal Maiden's small HP pool.
Bristleback
* Lycan's wolves deal little damage to Bristleback, and are easily killed by Quill Spray, even when they're invisible.
* Lycan's lack of burst damage makes it very hard for him to kill Bristleback, especially when his back is turned.
Additional:
* Quill Spray can be used to kill Lycan's summons.
* Bristleback allows him to stay alive against Lycan while dishing out counter attacks
* He can overpower Lycan with his Warpath instead.
Bristleback
* The damage from 
Burning Spear can be reduced by turning away from Huskar.
* Bristleback can bait Huskar into using 
Life Break on him, then turn around and receive very little damage.
Additional:
* Bristleback's tankiness and Bristleback allow him to outlast Burning Spears' damage-over-time at almost any point in the game. In addition, if Huskar chooses to cast Life Break on Bristleback, Bristleback can simply turn around before it hits and receive little damage.
* Viscous Nasal Goo will reduce Huskar's low armor even further, and Quill Spray and Warpath will tear him down extremely quickly.
Bristleback
* Bristleback's abilities are nearly useless for Rubick to 
Spell Steal, as he does not gain the bonuses from Warpath.
Additional:
* Rubick deals little damage on his own, and Bristleback can simply shrug off all his spells and chase Rubick down with his Quill Spray and the damage bonus from Warpath.
* Rubick does not tend to charge forward in teamfights, stay in the front lines under most circumstances, yet effective casts of Quill Spray and Viscous Nasal Goo requires the opposite as they require multiple casts and close range to add up stacks.
* Rubick does not benefit from Warpath through casting the stolen spell.
Bristleback
* Bristleback is one of the hardest heroes to gank with a 
Meat Hook and 
Dismember combo, and attempts to do so sometimes backfire on Pudge.
Additional:
* Pudge is particularly susceptible to Bristleback's Viscous Nasal Goo and Quill Spray due to his naturally low armor and poor agility gain.
* Bristleback, in combination with his strength gain, high health, common itemization for magic resistance and damage reduction from Bristleback makes him a poor target for Pudge.
Bristleback
* Quill Spray will hit Riki even when he is invisible.
* 
Cloak and Dagger's bonus backstab damage is rendered irrelevant against Bristleback.
* 
Smoke Screen does not stop Bristleback's passive from activating.
* Due to Bristleback's natural tankiness, he is an ideal 
Gem of True Sight carrier, directly countering Riki's invisibility.
Additional:
* The bonus Backstab damage from Cloak and Dagger is rendered irrelevant with Bristleback and hurts Riki more than him because of the passive Quill Spray.
* Riki can still get damaged by Bristleback's Quill Spray while invisible, and it can be hard to deal with in lane.
* Bristleback is not too bothered by Smoke Screen. Though he cannot use Quill Spray manually inside it, it still procs passively when he takes damage from the back. The movement speed from Warpath allows him to get out of the area easily.
* Due to Bristleback's natural tankiness, he is an ideal Gem of True Sight carrier.
* Riki rarely buys 
Silver Edge to break Bristleback's passive because the invisibility aspect of it is redundant.
Bristleback
* Quill Spray's constant AoE damage will hit Dark Willow even in Shadow Realm. Its automatic damage will hurt her if she tries to get close and use Bedlam.
Bristleback
* Quill Spray is very effective against Io, as it has very low armor and has to stay close to the fight to not break its Tether.
Bristleback
* Combo Quill Spray and items Blade Mail can easily trigger from Focus Fire damage.
Additional:
* Using Focus Fire on Bristleback tends to fare badly for Windranger, as he can trigger passive Quill Sprays many times, especially when she attacks him from behind. In addition, Windrun does not protect her from both Viscous Nasal Goo and Quill Spray, rendering her helpless.
* Bristleback's natural tankiness makes it hard for Windranger to effectively burst her down throughout the game.
* Bristleback tends to continuously spam Viscous Nasal Goo to slow down Windranger when she uses Windrun to escape, potentially allowing him to outrun her with his Warpath stacks.
* Bristleback can build 
Lotus Orb to reflect Shackleshot and Focus Fire back at Windranger.
Bristleback
* Quill Spray will hit Sand King inside 
Sand Storm, damaging him and putting Sand King's Blink Dagger on cooldown, preventing him from escaping.
* 
Epicenter's numerous damage ticks will trigger Bristleback's passive repeatedly during teamfights.
Bristleback
* Bristleback's constant harass from Quill Spray will greatly hurt Enigma's laning and kill his Eidolons.
* However, Bristleback has no way of canceling 
Black Hole at all. And Bristleback is not a hero that goes for disabling items to counter that problem.
Bristleback
* Arc Warden has relatively lower armor and mobility, which makes him an easy target to apply Quill Spray and Viscous Nasal Goo stacks.
* Arc Warden also does not like to build a Silver Edge as it takes a long time to build up and may slow down the timings for other important items needed in the game like 
Gleipnir.
* However, do note that in a game where Arc Warden's team has many jumping capabilities or good passives, like a 
Tidehunter or Spectre, a Silver Edge becomes incredibly valuable on Arc Warden as not only can he run away from the jumps, he effectively gets 2 breaks, and Bristleback may not be the best pick.
Bristleback
* Fortune's End cannot dispel Warpath stacks on Bristleback or Quill Spray stacks on allies.
* Bristleback can heavily reduce Oracle's damage output. With it, Oracle may accidentally heal Bristleback with Purifying Flames, especially if Bristleback has bonus magic resistance.
Bristleback
* Heroes with damage-over-time abilities easily allow Bristleback to turn his back in order to proc Bristleback continuously and to massively reduce to damage dealt to him: 
Arc Warden, 
Venomancer, Luna.
Bristleback
* Heroes that have AoE damage: 
Lina, Keeper of the Light, 
Timbersaw, 
Leshrac, Bristleback, Axe.
Bristleback
* Axe, Bristleback, 
Centaur Warrunner, Spirit Breaker, Pudge, 
Huskar, Wraith King, Doom: These heroes are too tanky for Puck to burst down. Also, all of them have spells which can deal with and shut Puck down reliably.
Tiny
* Squishy heroes, usually supports, like Lion, Ancient Apparition, Keeper of the Light etc can die quickly to Tiny's magic burst.
Bristleback
* Heroes with damage-over-time abilities easily allow Bristleback to turn his back in order to proc Bristleback continuously and to massively reduce to damage dealt to him: Arc Warden, Venomancer, Luna.
Additional:
* Quill Spray and Bristleback harass Luna more efficiently than she does with Lucent Beam.
* Bristleback helps return a lot of damage to Luna’s team if she uses her nukes on him and he has his back to her.
* Viscous Nasal Goo and Warpath are enough to outrun a speedy Luna.
* Bristleback tends to be a frequent carrier of 
Crimson Guard and 
Eternal Shroud, which are good protection from 
Moon Glaives and 
Eclipse.
* For the same reasons, Bristleback makes a very powerful ally for Luna when they are in the same team.
Tiny
* Side lanes with disables will greatly reduce the likeliness Void Spirit will be willing to rotate: Sven, Tiny, Wraith King, 
Ogre Magi.
Bristleback
* Bristleback's Viscous Nasal Goo can catch and slow Bounty Hunter. Warpath and Quill Spray can defeat him quickly due to his small HP pool when compared to Bristleback's.
Bristleback
* Other heroes who has armor and slow debuffs won't allow Medusa to disengage from combat: Tidehunter, Bristleback, Slardar.
Tiny
* Due to Tiny's non-existent agility gain, high physical damage heroes are more effective against him (Clinkz, Templar Assassin, Ursa, Wraith King etc).
Tiny
* Heroes that have disposable area-targeted spells can force her to undo her Meld: Leshrac, 
Puck, Tiny, 
Jakiro,. An experienced Templar Assassin could try to use Refraction before Meld so she can tank through those damage without getting her Blink disabled.
Tiny
* 
Chaos Bolt and 
Reality Rift makes Tiny's low mobility non existent.
* 
Chaos Strike means Chaos Knight will most likely survive longer in a duel between the two because Tiny has much lower attack speed.
* Chaos Knight has a 3.2 strength growth, making him one of the most tanky heroes and a very difficult target for Tiny to burst.
Bristleback
* Quill Spray quickly destroys Chaos Knight's 
Phantasms.
Bristleback
* 
Essence Shift allows Slark to hit Bristleback freely whether on the front or back, stealing attributes and make Bristleback much less tanky.
* 
Pounce can be used to disengage and recover lost HP with his ultimate passive, and can return to fight in a short period while Bristleback is already injured and got some of his attributes stolen.
* 
Dark Pact makes it near impossible to keep the Viscous Nasal Goo debuff on Slark.
* Although Dark Pact cannot dispel Quill Spray, meaning that Slark will still receive quill stack damage even if he used 
Shadow Dance before.
* Slark builds Silver Edge in almost every game, an item that greatly counters Bristleback.
Tiny
* Toss and Avalanche deals heavy damage to Slark in the early game, making Tiny a very dangerous target to gank.
* Tiny has 0 agility, which means Slark's Essence Shift permanent agility steal does not do much against him.
Bristleback
* Spirit Breaker's 
Nether Strike with 
Aghanim's Shard disables Bristleback's passives.
Bristleback
* Heroes who can continue dealing damage even while being stunned: Luna, 
Razor, Axe, Bristleback, Leshrac, 
Death Prophet, Jakiro.
Bristleback
* Heroes that withstand damage like Timbersaw, Bristleback, Dragon Knight and others will have their durability largely reduced when hit by an Ice Blast due to the risk of shattering.
Tiny
* Squishy heroes, usually supports, like Lion, Ancient Apparition, Keeper of the Light etc can die quickly to Tiny's magic burst.
Bristleback
* Axe forces Bristleback to turn around with 
Berserker's Call, allowing allies to attack him without fear of his passive.
Bristleback
* Heroes who can stop Axe from getting close will severely inhibit his presence in fights: Bristleback, 
Crystal Maiden, Batrider, Arc Warden, 
Winter Wyvern, 
Clockwerk
Tiny
* Familiars will easily be able to kite heroes with a short range or with low attack speed. For example, Tiny and Undying have a very hard time killing Familiars.
Tiny
* Tiny can deal with 
Visage's 
Gravekeeper's Cloak quickly, as Avalanche deals damage in enough instances to completely remove all 4 layers of the passive. With Visage's lower than average Armor, a well positioned stun can allow Tiny to kill Visage easily.
Additional:
* Tiny's Avalanche removes a significant number of layers from Gravekeeper's Cloak. When combined with Toss burns through all of Gravekeeper's Cloak while doing triple times Toss damage to Visage in midair.
* Tiny's already high damage coupled with 
Tree Grab's attack modifier will make short work of Visage's Familiars.
Tiny
* Tiny has low movement speed and attack speed, making him vulnerable to Viper's slows.
Corrosive Skin provides magic resistance to lower Tiny's magic burst damage.
*
Bristleback
*
Nethertoxin disables Bristleback's passive.
Viper Strike and 
Poison Attack slow down Bristleback's movement speed, making him unable to get out from Nethertoxin.
Viper Strike can disable 
Bristleback and prevents 
Warpath from building stacks. Besides losing his defensive passive, Bristleback also loses his ability to build up damage over lengthy battles.
Poison Attack and 
Viper Strike.
*
Additional:
*
* Viper can perpetually kite Bristleback with