Viper
* 
Rage ignores all of Viper's magical damage, although 
Viper Strike can pierce spell immunity and slows him down.
* 
Feast and 
Open Wounds from 
Aghanim's Shard can be combined to heal through Viper's physical damage.
* 
Aghanim's Scepter upgraded 
Infest can be used to disarm Viper, preventing him from using 
Poison Attack on Lifestealer's allies.
Chen
* Rage gives Lifestealer spell immunity, Chen and his converted creeps have little to no ways of fighting back against Lifestealer whenever he activates it.
* Feast allows Lifestealer to recover himself by damaging Chen's creeps.
* Chen has no escape mechanisms, so he will often be unable to escape from slows applied with 
Ghoul Frenzy.
* Open Wounds from Aghanim's Shard can severely slow down Chen, and allow Lifestealer and his team to heal themselves by attacking Chen. Open Wounds can also fester and spread if Chen takes enough damage that will trigger the spread while he is affected with Open Wounds.
* Infest allows Lifestealer to infest into one of Chen's converted creeps and take control of it, which allows Lifestealer to either escape from Chen or surprise him. Aghanim's Scepter upgraded Infest can disarm Chen and allow Lifestealer to attack Chen from within, even if Chen is spell immune.
Viper
* Viper's lack of escape and durability means he can be ran over in a laning stage by 
Spawn Spiderlings.
* Broodmother can bring Viper down quickly with 
Insatiable Hunger activated.
Chen
* Chen has no area-of-effect spells to deal with Broodmother's spiderlings and must rely on his creeps to take care of them.
* Spawn Spiderlings can kill Chen's creeps and spawn spiderlings in their place.
* 
Spin Web allows Broodmother to disrupt Chen's jungling.
* 
Silken Bola will cause Chen and his creeps's attack to miss more often while also making them more vulnerable to magical damage, especially if Broodmother picks 400 AoE Silken Bola talent.
* Broodmother is a natural 
Bloodthorn wielder, which will allow her to prevent Chen from trying to save himself with 
Hand of God while also making him more vulnerable to damage, and when combined with Insatiable Hunger, it will spell a quick and certain death for Chen. Bloodthorn's passive ability will also reduce any spell damage Chen tries to inflict with his creeps.
* 
Spinner's Snare from Aghanim's Scepter allows Broodmother to create invisible lines on her webs from Spin Web that will root Chen and his creeps, deal damage over time to them and reveal them if they unwittingly steps on them, disrupting Chen's jungling even more while also alerting Broodmother on their attempts to ambush her and her allies.
Additional:
* Chen has no area-of-effect spells to deal with Broodmother's spiderlings and must rely on his creeps to take care of them.
* Spawn Spiderlings can kill Chen's creeps and spawn spiderlings in their place.
* Spin Web allows Broodmother to disrupt Chen's jungling.
* Silken Bola will cause Chen and his creeps's attack to miss more often while also making them more vulnerable to magical damage, especially if Broodmother picks 400 AoE Silken Bola talent.
* Broodmother is a natural Bloodthorn wielder, which will allow her to prevent Chen from trying to save himself with Hand of God while also making him more vulnerable to damage, and when combined with Insatiable Hunger, it will spell a quick and certain death for Chen. Bloodthorn's passive ability will also reduce any spell damage Chen tries to inflict with his creeps.
* Spinner's Snare from Aghanim's Scepter allows Broodmother to create invisible lines on her webs from Spin Web that will root Chen and his creeps, deal damage over time to them and reveal them if they unwittingly steps on them, disrupting Chen's jungling even more while also alerting Broodmother on their attempts to ambush her and her allies.
Viper
* Viper's frailty and low mobility make him an enticing Duel target and 
Corrosive Skin doesn't protect him against Legion Commander physical attacks.
* Press the Attack can dispel Poison Attack.
* Viper slows can easily negate by Overwhelming Odds movement speed.
Chen
* Chen's fragility and low mobility make him an enticing 
Duel target.
* 
Overwhelming Odds and 
Moment of Courage can take advantage of converted creeps's numbers.
* With enough damage from Duel stacks, Legion Commander can also often kill any of Chen's unfortunate allies before he can use Hand of God.
Additional:
* Chen's frailty and low mobility make him an enticing Duel target.
* Overwhelming Odds and Moment of Courage can take advantage of converted creeps' numbers.
* With enough damage from Duel stacks, Legion Commander can also often kill any of Chen's unfortunate allies before he can use Hand of God.
Viper
* 
Enfeeble weakens Viper's attack damage, any healing he receives and his cast range, which makes him unable to harass enemy heroes with 
Nethertoxin, Poison Attack and Viper Strike.
* 
Brain Sap allows Bane to heavily harass Viper, damaging him while healing Bane, which allows Bane to fight back against Viper's damage over time output, even through debuff immunity from 
Black King Bar.
* Viper's Corrosive Skin is useless against Bane as all of his damaging abilities deal Pure damage.
* Viper has no solutions to cancel 
Fiend's Grip and in addition, he hates buying disabling items like 
Eul's Scepter of Divinity.
Additional:
* Enfeeble weakens Viper's attack damage, any healing he receives and his cast range, which makes him unable to harass enemy heroes with Nethertoxin, Poison Attack and Viper Strike.
* Viper's Corrosive Skin is useless against Bane as all of his damaging abilities deal Pure damage.
* Viper has no solutions to cancel Fiend's Grip and in addition, he hates buying disabling items like Eul's Scepter of Divinity.
Chen
* Even though Bane has no abilities to deal with multiple Chen's creeps, skilled Bane can easily counter this problem by going for Aghanim's Shard, which will allow Brain Sap to easily kill Chen's creeps and by buying either 
Gleipnir or 
Mjollnir.
* Fiend's Grip can disable Chen or any of his allies and often finish them before he can save them with Hand of God. And to make things worse, Chen has no way to cancel Fiend's Grip on his own, and must rely on outside from {U:Centaur Conqueror} or {U:Mud Golem} under his control.
Viper
* Clinkz does not have any passive abilities at all, making Nethertoxin nearly useless.
* Viper's Corrosive Skin provides no protection against Clinkz's physical damage output.
Chen
* Clinkz's 
Skeleton Walk allows him to easily sneak on Chen and bypass his creeps. It also allows him to escape from them.
* Clinkz can easily kill Chen's creeps with 
Death Pact and gain gold, health, damage and abilities from them when upgraded with Death Pact Steal creep abilities talent.
* Clinkz naturally loves buying Gleipnir, which allows him to easily root Chen and his creeps and to kill them more easily with 
Burning Barrage from Aghanim's Shard.
* Clinkz can kill Chen or any of his allies with his physical damage burst from 
Strafe, 
Tar Bomb and Burning Barrage from Aghanim's Shard before he can use Hand of God. Especially when Clinkz has Gleipnir and 
Daedalus. Clinkz can also buy Bloodthorn to prevent Chen from even trying to use Hand of God.
Viper
* Voodoo Restoration heals to counter damage over time of Viper abilities.
* Viper has no way to cancel Death Ward, even through 
Rod of Atos.
Chen
* 
Paralyzing Cask will repetively bounce between Chen and his converted creeps every single time. This can get even worse if Witch Doctor buys Aghanim's Scepter that will allow his 
Death Ward to bounce between Chen and his converted creeps.
* Paralyzing Cask, 
Maledict and Death Ward combination will often kill Chen's allies before he can save them with Hand of God. And to make things worse, Chen has no way to cancel Death Ward on his own, and must rely on outside from {U:Centaur Conqueror} or {U:Mud Golem} under his control.
* 
Voodoo Switcheroo from Aghanim's Shard cannot be interrupted by Chen's creeps at all because Witch Doctor is hidden for it's duration.
Additional:
* Paralyzing Cask will repetively bounce between Chen and his converted creeps every single time. This can get even better if Witch Doctor buys Aghanim's Scepter that will allow his Death Ward to bounce between Chen and his converted creeps.
* Paralyzing Cask, Maledict and Death Ward combination will often kill Chen's allies before he can save them with Hand of God. And to make things better, Chen has no way to cancel Fiend's Grip on his own, and must rely on outside from {U:Centaur Conqueror} or {U:Mud Golem} under his control.
* Voodoo Switcheroo from Aghanim's Shard cannot be interrupted by Chen's creeps at all because Witch Doctor is hidden for it's duration.
Viper
* Pugna's 
Decrepify allows him to save allies from being ganked by Viper, since Viper mostly relies on direct attacks in order to deal damage.
* 
Nether Ward can discourage Viper from spamming his abilities.
* Viper's damage over time is not enough to kill Pugna as he will have more than enough time to save himself (or his allies) with 
Life Drain and Viper has no solutions to cancel it.
* Pugna has no passive abilities, which renders Nethertoxin nearly useless.
Chen
* 
Nether Blast can deal high damage to Chen and clear waves of his creeps.
* Decrepify can be used to waste the duration of 
Penitence.
* Nether Ward can discourage Chen from using Penitence, 
Holy Persuasion and Hand of God due to their fairly high mana costs.
* Life Drain can often kill Chen or any of his allies before he can save them with Hand of God thanks to it's high damage and low cooldown.
Viper
* 
Shukuchi ignores slows and allows Weaver to escape Viper's onslaught.
* 
Time Lapse dispels Poison Attack and Corrosive Skin and undoes poison damage.
* Weaver's high burst damage allows him to kill Viper before being killed.
Chen
* Weaver can easily kill Chen's creeps and kite Chen with 
The Swarm and Shukuchi.
* Neither Chen nor his converted creeps have burst damage at all, so Weaver will always have plenty of time to save himself with Time Lapse or his allies with Aghanim's Scepter upgraded Time Lapse.
Viper
* Naga Siren can easily disjoint, and dispel Corrosive Skin with Mirror Image.
* Since Viper is mostly a single-target hero, he will not have almost any chance against Naga Siren because she is an illusion based hero.
* Viper has no burst damage, so Naga Siren will have plenty of time to use Aghanim's Shard upgraded 
Song of the Siren heal her allies before Viper can finish them off.
Chen
* Naga Siren can make landing Chen's combo very hard due to her being an illusion hero thanks to 
Mirror Image.
* 
Rip Tide can deal big damage to Chen and reduce Chen's armor, as well as easily kill all of Chen's creeps.
* Naga Siren often builds 
Radiance, which allows her to quickly clear Chen's creeps.
* 
Ensnare will prevent Chen from escaping.
* With Aghanim's Scepter, Naga Siren can get access to 
Reel In, which can separate Chen from his creeps and draw him closer to Naga Siren and her team to finish her off. To make things worse, Chen has no way to cancel Reel In on his own, and must rely on outside from {U:Centaur Conqueror} or {U:Mud Golem} under his control.
* Carry or Nuker Naga Siren can often finish off Support Chen before he can have a chance to activate Hand of God.
Additional:
* Naga Siren can make landing Chen's combo very hard due to her being an illusion hero.
* Rip Tide can deal big damage to Chen and reduce Chen's armor, as well as easily kill all of Chen's creeps.
* Naga Siren often builds Radiance, which allows her to quickly clear Chen's creeps.
* Ensnare will prevent Chen from escaping.
* With Aghanim's Scepter, Naga Siren can get access to Reel In, which can separate Chen from his creeps and draw him closer to Naga Siren and her team to finish her off. To make things worse, Chen has no way to cancel Reel In on his own, and must rely on outside from {U:Centaur Conqueror} or {U:Mud Golem} under his control.
* Carry or Nuker Naga Siren can often finish off Support Chen before he can have a chance to activate Hand of God.
Viper
* If Rubick can use 
Spell Steal to take Nethertoxin, he will be able to disable Corrosive Skin, reducing much of Viper's durability.
* He can also steal Viper Strike, which can be used to hinder a hero on your team (or multiple heroes, if Rubick has Aghanim's Scepter).
Chen
* If Rubick can use Spell Steal to steal Holy Persuasion, he will be able to turn Chen's creeps against him, reducing much of Chen's efficiency.
* Rubick can also steal Hand of God and use it to save his teammates during teamfights and Penitence to slow down Chen and make Rubick and his allies attack him faster.
* 
Telekinesis can be used to coordinate gank on Chen and prevent him from escaping.
* 
Fade Bolt can deal high damage to both, Chen and his creeps and weaken their damage output.
Viper
* Viper is kind of a mixed package. Tinker is very good against him. but stands a better chance against him than most heroes.
* Viper has a high innate magic resistance, but relies on his primary attacks to really deal damage. making Laser an effective way to save allies from him, and deal damage. Keep in mind that his Corrosive Skin will prevent Tinker from blinking.
* Viper's Viper Strike and Poison Attack will also have a hard time damaging allies through Tinker's constant casting of 
Defense Matrix.
* Viper has no solutions to cancel 
Rearm nor any of Tinker's escape attempts with 
Boots of Travel
* However, if Viper gets a jump on Tinker first. Tinker will unlikely survive versus Viper.
Chen
* Heroes with either magical, physical or pure damage burst: 
Bane, 
Ember Spirit, 
Leshrac, 
Lina, 
Luna, 
Nyx Assassin, 
Phantom Assassin, 
Skywrath Mage, 
Tinker, 
Ursa, 
Void Spirit.
Viper
* Viper cannot interrupt heroes with powerful channeling abilities: Bane, 
Enigma, 
Shadow Shaman, 
Warlock
Chen
* 
Shackles prevents Chen from acting, and damages him while healing Shadow Shaman, also allowing Shadow Shaman's allies to kill him faster. Aghanim's Shard upgraded Shackles can also summon four more 
Mass Serpent Wards to attack Chen while he is disabled. And to make things worse, Chen has no way to cancel Shackles on his own, and must rely on outside from {U:Centaur Conqueror} or {U:Mud Golem} under his control.
* 
Ether Shock and Mass Serpent Ward can often not only kill Chen's allies before he can save them with Hand of God, but they can also be used to destroy Chen's creeps easily thanks to their high damage and area-of-effect.
* 
Hex will prevent Chen from any attempt to save himself or his allies with Hand of God.
Additional:
* Shackles prevents Chen from acting, and damages him while healing Shadow Shaman, also allowing Shadow Shaman's allies to kill him faster. Aghanim's Shard upgraded Shackles can also summon four more Mass Serpent Wards to attack Chen while he is disabled. And to make things worse, Chen has no way to cancel Shackles on his own, and must rely on {U:Centaur Conqueror} or {U:Mud Golem} creeps under his control to be able to do so.
* Ether Shock and Mass Serpent Ward can often not only kill Chen's allies before he can save them with Hand of God, but they can also be used to destroy Chen's creeps easily thanks to their high damage and area-of-effect.
* Hex will prevent Chen from any attempt to save himself or his allies with Hand of God.
Viper
* Viper cannot interrupt heroes with powerful channeling abilities: Bane, Enigma, Shadow Shaman, Warlock
Chen
* 
Demonic Conversion can be used to instantly kill Chen's creeps and give Enigma gold in process.
* 
Midnight Pulse can greatly damage Chen and his creeps and disrupt Chen's jungling.
* 
Black Hole combined with follow-ups from Enigma's allies can often finish Chen or any of his allies before he can use Hand of God. To make things worse, Chen has no way to cancel Black Hole on his own, especially if Enigma chooses to channel Black Hole in center, and must rely on outside from {U:Centaur Conqueror} or {U:Mud Golem} under his control.
Viper
* Heroes who do not have nor rely on passive abilities make Nethertoxin much less effective: 
Clinkz, 
Pugna, 
Nature's Prophet, 
Dark Seer, 
Lycan, 
Tusk
Chen
* Lycan can clear waves of Chen's creeps with his wolves from 
Summon Wolves, especially once Lycan takes +2 Wolves summoned talent. And even though Chen can convert one of his wolves with Holy Persuasion, Lycan can counter this by buying 
Helm of the Overlord to regain control of it. Uncontrollable wolves summoned from Aghanim's Shard upgrade Summon Wolves cannot be converted with Holy Persuasion.
* 
Shapeshift allows him to chase down Chen and kill him easily.
* 
Howl can reduce attack damage of both, Chen and his creeps.
Viper
* Heroes who do not have nor rely on passive abilities make Nethertoxin much less effective: Clinkz, Pugna, Nature's Prophet, Dark Seer, Lycan, Tusk
Chen
* Dark Seer's 
Vacuum and 
Ion Shell can clear a wave of Chen's Creeps effectively.
* 
Surge applies haste movement and negates the slow from Penitence, allowing Dark Seer to easily escape from Chen and his creeps.
* Dark Seer's full combo from Dark Seer's Vacuum, 
Wall of Replica and 
Normal Punch from Aghanim's Scepter can often kill Chen or any of his allies before he can save them with Hand of God.
Additional:
* Dark Seer's Vacuum and Ion Shell can clear a wave of Chen's Creeps effectively.
* Surge applies haste movement and negates the slow from Penitence, allowing Dark Seer to easily escape from Chen and his creeps.
* Dark Seer's full combo from Dark Seer's Vacuum, Wall of Replica and Normal Punch from Aghanim's Scepter can often kill Chen or any of his allies before he can save them with Hand of God.
Viper
* 
Ball Lightning allows Storm Spirit to escape through Viper Strike, wasting Viper's mana.
* It's also very easy to wait out the duration of Nethertoxin's break.
Chen
* Heroes that can easily bypass Chen's creeps to get to Chen: 
Riki, Tusk, Clinkz, 
Sniper, 
Slark, Phantom Assassin, Void Spirit, 
Storm Spirit, Ember Spirit, 
Earth Spirit, 
Spirit Breaker.
Viper
* The Keeper of the Light easily farms on the line against the Viper, due to the fact that it has a long-range 
Illuminate, and the Viper, in turn, cannot use its advantage of dominance on the center line, due to the fact that it does not reach the Keeper of the Light
Additional:
* The Keeper of the Light easily farms on the line against the Viper, due to the fact that it has a long-range Illuminate, and the Viper, in turn, cannot use its advantage of dominance on the center line, due to the fact that it does not reach the Keeper of the Light
Chen
* Heroes with summons/illusions/neutral creep armies: 
Beastmaster, 
Chen, 
Naga Siren
Viper
* Illusion or summon-based heroes can be a problem to Viper due to his lack of AoE damage: Naga Siren, 
Phantom Lancer, Beastmaster
Chen
* 
Wild Axes, 
Primal Roar and 
Drums of Slom can deal high damage to Chen and clear waves of his creeps.
* Even though Chen can take control of the Boar from 
Call of the Wild Boar at any time with Holy Persuasion, which could put Beastmaster in a disadvantage against Chen. Skilled Beastmaster can buy Helm of the Overlord to regain control of it to counter this problem.
* Smart Beastmaster can also buy Bloodthorn to prevent Chen from taking control of the Boar from Call of the Wild Boar and make Chen more vulnerable to Beastmaster.
Viper
* Viper Strike can be countered through Snowball, wasting Viper's mana through his ultimate. It's Viper Strike's break is also useless because he has no passive abilties at all. And to make things worse, Viper Strike cannot disable 
Walrus PUNCH! because it's an auto-cast ability
* As Tusk is a natural 
Silver Edge wielder, he can use it to disable Viper's magic resistance from Corrosive Skin, and make him vulnreable to his other allies.
Chen
* Heroes that can easily bypass Chen's creeps to get to Chen: Riki, Tusk, Clinkz, Sniper, Slark, Phantom Assassin, Void Spirit, Storm Spirit, Ember Spirit, Earth Spirit, Spirit Breaker.
Viper
* Although Viper Strike cannot be dispelled by Doppelganger, Viper's lack of mobility and AoE damage makes him an easy target for Phantom Lancer.
* Viper's various slows do not work against 
Phantom Rush.
* Although Phantom Lancer should be wary due to Nethertoxin applying Break.
Additional:
* Phantom Lancer can overwhelm Viper with spawned illusions from 
Spirit Lance and 
Doppelganger. In addition, 
Diffusal Blade, a core item on Phantom Lancer, burns Viper's limited mana pool, reducing his potential poison damage.
* Viper's various slows do not work against Phantom Rush. Additionally, it is almost impossible to keep Lancer inside Nethertoxin's radius in order to disable the passive.
Chen
* Illusion and heroes with summons are difficult to kill with Chen's single-target offensive spells: 
Terrorblade, Phantom Lancer, 
Chaos Knight, 
Broodmother, Naga Siren, Lycan, 
Visage, Beastmaster, Warlock, 
Wraith King. And even though Chen can convert enemy summons with Holy Persuasion, their much greater numbers will often overwhelm Chen and his creeps.
Viper
* Even though Luna has a hard time laning against Viper due to Nethertoxin being able to disable 
Moon Glaives and 
Lunar Blessing, Luna can take out Viper once she builds either Black King Bar or Silver Edge which will allow her to attack Viper freely.
* 
Eclipse can often finish off Viper from early-to-mid stages of the game before he can retaliate as Corrosive Skin gives little magic resistance to him early on.
* 
Manta Style is an item that Luna commonly buys in most of the games, which lets her disjoint Viper Strike. Additionally, illusions from Manta Style can make Viper waste time attacking them.
Additional:
* Even though Luna has a hard time laning against Viper due to Nethertoxin being able to disable Moon Glaives and Lunar Blessing, Luna can take out Viper once she builds either Black King Bar or Silver Edge which will allow her to attack Viper freely.
* Eclipse can often finish off Viper from early-to-mid stages of the game before he can retaliate as Corrosive Skin gives little magic resistance to him early on.
* Manta Style is an item that Luna commonly buys in most of the games, which lets her disjoint Viper Strike. Additionally, illusions from Manta Style can make Viper waste time attacking them.
Chen
* Luna's Moon Glaives combined with Lunar Blessing can easily kill Chen's creeps.
* Eclipse can be used after Luna clears all of Chen's creeps to easily kill Chen or any of his allies before he can save them with Hand of God. This can get even worse if Luna buys Aghanim's Scepter. And Chen is not a hero that likes to buy Black King Bar to counter this problem.
Additional:
* Luna's Moon Glaives combined with Lunar Blessing can easily kill Chen's creeps.
* Eclipse can be used after Luna clears all of Chen's creeps to easily kill Chen or any of his allies before he can save them with Hand of God. This can get even worse if Luna buys Aghanim's Scepter. And Chen is not a hero that likes to buy Black King Bar to counter this problem.
Chen
* Heroes that create illusions: 
Spectre, 
Shadow Demon, Phantom Lancer, Naga Siren, Chaos Knight, Terrorblade) or bring other units into the fight (such as Nature's Prophet, 
Lone Druid, Chen, 
Enchantress, 
Meepo and 
Arc Warden) can cause Eclipse to strike the illusions/summons unintentionally. However, in many cases Moon Glaives can resolve this issue and eliminate them before activating Eclipse, but that will require lots of farming for right-click items.
Viper
* Viper cannot interrupt heroes with powerful channeling abilities: Bane, Enigma, Shadow Shaman, Warlock
Chen
* Illusion and heroes with summons are difficult to kill with Chen's single-target offensive spells: Terrorblade, Phantom Lancer, Chaos Knight, Broodmother, Naga Siren, Lycan, Visage, Beastmaster, Warlock, Wraith King. And even though Chen can convert enemy summons with Holy Persuasion, their much greater numbers will often overwhelm Chen and his creeps.
Viper
* Heroes that can drain mana negatively affect Viper's ability to use Poison Attack, Nethertoxin and Viper Strike: 
Lion, 
Anti-Mage
Chen
* Heroes with channeling spells, for Chen has no disables on his own, hates buying disabling items and his creeps are often not fast enough to cancel them: Enigma's Black Hole, 
Witch Doctor's Death Ward, Shadow Shaman's Shackles, Lion's 
Mana Drain, Bane's Fiend's Grip, 
Pudge's 
Dismember, 
Crystal Maiden's 
Freezing Field, Pugna's Life Drain, 
Dawnbreaker's 
Solar Guardian, and Naga Siren's Reel In from Aghanim's Scepter.
Chen
* Medusa's 
Split Shot can easily kill Chen's creeps.
* 
Mystic Snake can quickly kill Chen's creeps and deal intense damage for every killed creep while also draining their mana with each bounce. Aghanim's Scepter upgraded Mystic Snake can also disable both, Chen and his creeps upon impact.
* 
Mana Shield will make it impossible for Chen to burst down Medusa.
* 
Stone Gaze can disable Chen from using Hand of God to save himself or his allies.
Chen
* 
Firestorm will easily clear Chen's creeps.
* 
Pit of Malice will trap Chen and render him helpless.
* 
Atrophy Aura gives bonus damage to Underlord for each killed creep and weakens Chen's damage output.
* 
Fiend's Gate can counter Chen's pushing attempts, and he has nothing to intercept it.
Additional:
* Firestorm will easily clear Chen's creeps.
* Pit of Malice will trap Chen and render him helpless.
* Atrophy Aura gives bonus damage to Underlord for each killed creep and weakens Chen's damage output.
* Fiend's Gate can counter Chen's pushing attempts, and he has nothing to intercept it.
Chen
* 
Burrowstrike, 
Sand Storm, 
Caustic Finale and 
Epicenter will deal a large amount of damage to Chen and his creeps.
Viper
* Viper's Nethertoxin cannot disable 
Reincarnation, which could put him in disadvantage against Wraith King if his whole team is with him.
* In addition, Viper doesn't like buying Diffusal Blade, which is the only item that can help him against Wraith King.
* Wraith King's high burst damage allows him to kill Viper before being killed.
Chen
* Illusion and heroes with summons are difficult to kill with Chen's single-target offensive spells: Terrorblade, Phantom Lancer, Chaos Knight, Broodmother, Naga Siren, Lycan, Visage, Beastmaster, Warlock, Wraith King. And even though Chen can convert enemy summons with Holy Persuasion, their much greater numbers will often overwhelm Chen and his creeps.
Viper
* Melee heroes with low mobility can be kited and killed by Viper: 
Treant Protector, 
Kunkka, 
Alchemist, 
Troll Warlord, Wraith King, 
Tiny, 
Sven.
Chen
* 
Arcane Orb and 
Sanity's Eclipse can often kill Chen or his allies before he can save them with Hand of God.
* Arcane Orb, 
Astral Imprisonment and Sanity's Eclipse can clear waves of Chen's converted creeps.
Viper
* 
Windrun evades Poison Attack and counteracts the slow.
* Viper's low mobility makes him an easy 
Shackleshot target.
* 
Focus Fire grants Windranger significant physical damage output to quickly wear Viper down.
* 
Powershot is a strong harassment and zoning tool against Viper in lane.
Chen
* Heroes with evasion will cause Chen and his creeps to struggle in attacking them and will waste much of Penitence's power: Phantom Assassin, 
Windranger, 
Hoodwink.
Viper
* Since Windranger is bad against magical damage, heroes with continuous magical damage or magical nukes can blast her: 
Zeus, Tinker, Leshrac, 
Viper, Skywrath Mage, Lion, Lina, 
Venomancer.
Chen
* 
Silence will prevent Chen from activating Hand of God.
* 
Crypt Swarm and 
Exorcism can clear Chen's creeps and heavily damage Chen.
* 
Spirit Siphon heavily damages Chen and slows him, while healing Death Prophet.
Additional:
* Silence will prevent Chen from activating Hand of God.
* Crypt Swarm and Exorcism can clear Chen's creeps and heavily damage Chen.
* Spirit Siphon heavily damages Chen and slows him, while healing Death Prophet.
Chen
* 
Dual Breath, 
Liquid Fire, 
Liquid Frost from Aghanim's Shard and 
Macropyre allows Jakiro can clear Chen's creeps, and kill his allies before he uses Hand of God.
* Macropyre can quickly clear Chen's creeps and deal intense damage to his allies, Aghanim's Scepter upgraded Macropyre can also deal pure damage to Chen and his creeps and allies and pierce spell immunity.
Additional:
* Jakiro's damage over time force Chen to use Hand of God prematurely, potentially wasting chance to save his allies during teamfight.
* Dual Breath and Macropyre can be used to disrupt Chen's jungling work.
Viper
* As Viper focuses on single-target damage, he has trouble fighting off Phantasm illusions.
* Reality Rift counteracts Viper's slows and reduces his already low durability against physical damage.
Additional:
* Viper has no response to the standard initiation combo of 
Reality Rift into 
Chaos Bolt.
* 
Phantasm and 
Chaos Strike can eliminate Viper almost instantly with it's damage output.
* Besides Nethertoxin, Viper has no other ways of dealing with Phantasm.
Chen
* Illusion and heroes with summons are difficult to kill with Chen's single-target offensive spells: Terrorblade, Phantom Lancer, Chaos Knight, Broodmother, Naga Siren, Lycan, Visage, Beastmaster, Warlock, Wraith King. And even though Chen can convert enemy summons with Holy Persuasion, their much greater numbers will often overwhelm Chen and his creeps.
Viper
* Heroes with Attack speed decreasing skills: 
Jakiro, Viper 
Lich
Chen
* 
Poison Touch severely slows down Chen, deals damage over time and weakens his armor every time he gets attacked by Dazzle or any of his allies. Aghanim's Shard upgraded Poison Touch can hex Chen and prevent him from saving his allies with Hand of God.
* Neither Chen nor his converted creeps have burst damage at all, so Dazzle will always have plenty of time to save his allies with 
Shallow Grave.
* Dazzle can use 
Shadow Wave can heal his allies, kill Chen's creeps and damage Chen himself.
* 
Bad Juju can weaken Chen's armor, and the armor of his creeps every time Dazzle casts a spell while strengthening armor of Dazzle's allies.
Chen
* 
Mortimer Kisses will quickly destroy Chen's creeps and might waste Hand of God.
Viper
* Almost all of Viper's damage revolves exclusively around single-target damage-over-time effects. Furthermore, without any hard disables, Terrorblade can almost always get a Sunder off.
* Viper has low mobility and Corrosive Skin doesn't protect against physical damage, which means that Terrorblade under Metamorphosis can quickly kill Viper.
Additional:
* Viper's damage over time and lack of disables makes him easy to 
Sunder.
* Viper's physical damage is mitigated by Terrorblade's high armor.
* Terrorblade under 
Metamorphosis can quickly kill Viper with heavy physical damage.
Chen
* Illusion and heroes with summons are difficult to kill with Chen's single-target offensive spells: Terrorblade, Phantom Lancer, Chaos Knight, Broodmother, Naga Siren, Lycan, Visage, Beastmaster, Warlock, Wraith King. And even though Chen can convert enemy summons with Holy Persuasion, their much greater numbers will often overwhelm Chen and his creeps.
Chen
* Heroes with no stun and escape abilities such as Terrorblade are vulnerable as Chen can easily gank lanes from the jungle early game and score kills using Penitence.
Viper
* Viper has no disable, which means he has no way of preventing Morphling from escaping from any of his abilities or keep him inside Nethertoxin.
* Viper is almost exclusively damage over time, which is weak against Morphling due to 
Attribute Shift (Strength Gain). Additionally, Morphling has no passive abilities, reducing Nethertoxin's effectiveness against him even further.
* Morphling can turn into Viper himself, allowing him to use any of Viper's abilities against him (excluding Viper Strike). This is particularly bad due to the fact that Viper is already a very slow hero, making Poison Attack and Corrosive Skin's slows especially difficult to deal with.
Chen
* Sticky Napalm slows Chen and his creeps and Flamebreak and Firefly can deal heavy damage to them.
* Flaming Lasso can pull Chen away from his creeps toward Batrider's team, often to certain death.
Additional:
* 
Sticky Napalm slows Chen and amplifies Batrider's damage.
* 
Flamebreak and 
Firefly can deal heavy damage to Chen and his creeps.
* 
Flaming Lasso pulls Chen away from his creeps, often to certain death.
Chen
* Heroes that can easily bypass Chen's creeps to get to Chen: Riki, Tusk, Clinkz, Sniper, Slark, Phantom Assassin, Void Spirit, Storm Spirit, Ember Spirit, Earth Spirit, Spirit Breaker.
Chen
* Heroes with either magical, physical or pure damage burst: Bane, Ember Spirit, Leshrac, Lina, Luna, Nyx Assassin, Phantom Assassin, Skywrath Mage, Tinker, Ursa, Void Spirit.
Chen
* Heroes with either magical, physical or pure damage burst: Bane, Ember Spirit, Leshrac, Lina, Luna, Nyx Assassin, Phantom Assassin, Skywrath Mage, Tinker, Ursa, Void Spirit.
Additional:
* Leshrac's AoE abilities make quick work of Chen's creep army.
Chen
* Heroes that can easily bypass Chen's creeps to get to Chen: Riki, Tusk, Clinkz, Sniper, Slark, Phantom Assassin, Void Spirit, Storm Spirit, Ember Spirit, Earth Spirit, Spirit Breaker.
Viper
* Heroes who do not have nor rely on passive abilities make Nethertoxin much less effective: Clinkz, Pugna, Nature's Prophet, Dark Seer, Lycan, Tusk
Chen
* Heroes with evasion will cause Chen and his creeps to struggle in attacking them and will waste much of Penitence's power: Phantom Assassin, Windranger, Hoodwink.
Chen
* Heroes that can instantly kill creeps greatly reduce the effectiveness of Chen's converted army: 
Lifestealer, 
Doom, 
Mirana, Clinkz.
Chen
* Alchemist's 
Acid Spray can heavily damage Chen's creeps and disrupt his jungling.
* Alchemist builds items like Radiance and 
Battle Fury, allowing him to quickly clear Chen's creeps.
* Alchemist's 
Greevil's Greed will grant him more bonus gold as he kills Chen's creeps.
Viper
* Viper can bully Alchemist out of mid lane quite easily, forcing him to either retreat into jungle, or stay harassed in lane, and get very few last hits. Vipers break also completely disables Greevil's greed which prevents Alchemist to earn his amazing amounts of money.
Chen
* 
Frostbite roots and disarms Chen's creeps for 10 seconds.
* Crystal Maiden has a lot of AOE damage between 
Crystal Nova and Freezing Field to clear Chen's creeps out side and during team fights.
Viper
* Heroes who can easily harass Crystal Maiden out of lane in the early game (Clinkz, Viper) can prevent Crystal Maiden from being able to level effectively, and can ultimately slow down her level 6, 12, and 18 to a point where enemy carries already have items to address her ultimate.
Chen
* 
Storm Hammer locks down Chen and his converted creeps.
* 
Great Cleave and 
God's Strength can destroy Chen and his creeps quickly.
* 
Warcry minimizes damage taken from creeps's attacks.
Additional:
* Great Cleave can quickly destroy Chen's creeps in team fights, before they have a chance to do much.
Viper
* Melee heroes with low mobility can be kited and killed by Viper: Treant Protector, Kunkka, Alchemist, Troll Warlord, Wraith King, Tiny, Sven.
Chen
* Enchantress can turn Chen's own creeps against him with 
Enchant. The creeps still keep the health buff Holy Persuasion granted them. Aghanim's Shard gives Enchantress 
Little Friends ability, which allows her to turn multiple of Chen's creeps all at once against him.
* 
Untouchable and 
Nature's Attendants make her difficult to kill.
Additional:
* Even though Chen can use Holy Persuasion on creeps controlled by Enchant, Enchantress can also use Enchant on Chen's creeps, making it somewhat of a double-edged sword type of matchup.
* Aghanim's Shard gives Enchantress Little Friends ability, which she can use to turn all of Chen's creeps against him for a short time when casted on him.
* 
Impetus's high burst damage can often kill any of Chen's allies before he can save them with Hand of God.
Viper
* Heroes with break can disable Untouchable for a while: Doom and Shadow Demon (via Aghanim's Scepter), Viper, Shadow Shaman with Hex Breaks talent.
Viper
* Nethertoxin breaks the damage block from Bulwark.
* Poison Attack and Viper Strike's slows make it difficult for Mars to contribute to fights due to his low mobility.
Additional:
* Viper Strike can disable 
Bulwark entirely, making Mars far less tanky. Using Nethertoxin inside 
Arena of Blood may discourage enemies from following up with Mars's initiation.
* Rod of Atos is currently common on Viper and keeps Mars in position long enough to be killed.
* However, Viper is not very tanky earlier in the game, so positioning against Mars is important for Viper since a well-timed 
Spear of Mars can be the end of Viper.
Viper
* The damage over time from Viper's Poison Attack and Viper Strike rapidly wear down Refraction charges, allowing Templar Assassin to be damaged. Additionally, Corrosive Skin causes her attacks to apply damage overtime on her as well.
* Nethertoxin is a big threat to Templar Assassin. Her initially low range making it very hard to deal against Nethertoxin in the laning phase. At any stage of the game, a Nethertoxin can always force her to undo her Meld.
Additional:
* All of Viper's abilities quickly burn through 
Refraction charges.
* Templar Assassin's short range, aside from 
Psi Blades' spill damage, makes her vulnerable to Poison Attack harassment.
* Templar Assassin usually buys health and armor items for damage. Outside of Black King Bar, Viper will almost always be able to kill her when Refraction is down.
Viper
* Nethertoxin disables Bristleback's passive.
* Viper Strike and Poison Attack slow down Bristleback's movement speed, making him unable to get out from Nethertoxin.
Additional:
* Viper Strike can disable 
Bristleback and prevents 
Warpath from building stacks. Besides losing his defensive passive, Bristleback also loses his ability to build up damage over lengthy battles.
* Viper can perpetually kite Bristleback with Poison Attack and Viper Strike.
Viper
* Tiny has low movement speed and attack speed, making him vulnerable to Viper's slows.
* Corrosive Skin provides magic resistance to lower Tiny's magic burst damage.
Viper
* Viper wins on the central line of Puck, because he has a huge damage from the Poison Attack ability, which Puck is not able to constantly avoid using 
Phase Shift, which will give Viper an advantage in the possible damage inflicted on each other
* Puck takes more damage than it does due to the passive Corrosive Skin ability of the Viper, which makes it unprofitable for the Puck to fight against the Viper at an early stage of the game, when the Puck has a very small pool of health.
Additional:
* Viper wins on the central line of Puck, because he has a huge damage from the Poison Attack ability, which Puck is not able to constantly avoid using Phase Shift, which will give Viper an advantage in the possible damage inflicted on each other
* Puck takes more damage than it does due to the passive Corrosive Skin ability of the Viper, which makes it unprofitable for the Puck to fight against the Viper at an early stage of the game, when the Puck has a very small pool of health
Viper
* Viper STrike cancels out 
Kraken Shell and stops the hard dispel from passively activating, preventing Tidehunter from functioning as a frontline tank.
* 
Anchor Smash is mostly irrelevant against a ranged hero like Viper.
* Tidehunter relies on the threat of 
Ravage, which has an obscenely long cooldown. Viper can exploit the downtime with his short cooldowns.
Viper
* Corrosive Skin minimizes the damage Viper takes from all of Disruptor's skills.
Viper
* Corrosive Skin severely reduces Zeus's damage output throughout the game.
* During the laning stage, Viper can abuse Zeus' reliance on spells by hugging the creep wave. Zeus will take constant damage over time from Corrosive Skin unless he drives Viper from the lane or returns to farming in his absence.
* Prior to buying 
Blink Dagger or 
Force Staff, Zeus is fragile and possesses low mobility. Any of Viper's numerous slows can set up an easy kill.
Additional:
* Corrosive Skin counters Zeus in lane by canceling the effects of 
Clarity as Zeus relies on Arc Lightning to farm and secure last hits.
* Corrosive Skin also increases Viper's magic resistance to shrug off Zeus's magical nukes.
* Nethertoxin breaks Static Field.
* Due to Zeus' poor mobility, Viper Strike will cripple Zeus and will allow Viper and his teammates to land a lot of attacks.
Viper
* Viper Strike prevents the lifesteal from Ransack.
* Meepo and his clones have a lack of magic resistance, so they're vulnerable to Poison Attack & Viper Strike directed onto one clone.
Viper
* Viper Strike breaks Multicast.
* Corrosive Skin minimizes the damage from Ignite and Fireblast.
Chen
* Due to Clockwerk's slow damage output, Chen can often save a trapped ally with Hand of God.
* Clockwerk does not have any source of damage to deal with Chen Creeps.
* Chen can use his creeps to block Clockwerk's attempts to use 
Hookshot.
Additional:
* Due to Clockwerk's very low damage output, Chen can often save a trapped enemy hero with Hand of God.
* Penitence's attack speed amplification allows Chen and his allies to kill Clockwerk quickly after his initiation.
* Chen's creeps can be used to block Hookshot initiation from all sides, as well as distribute Battery Assault's damage.
Viper
* Melee heroes with low mobility can be kited and killed by Viper: Treant Protector, Kunkka, Alchemist, Troll Warlord, Wraith King, Tiny, Sven.
Chen
* Venomancer's damage over time can force Chen to use Hand of God prematurely, potentially wasting a chance to save his allies during a teamfight.
* Venomancer's 
Poison Nova, 
Venomous Gale and 
Plague Ward can easily kill Chen's creeps.
Viper
* Corrosive Skin means Viper can often outlast Venomancer in a battle of attrition.
* Venomancer has no mobility without items, which makes him vulnerable to constant slows.
Chen
* Any hero that can outrange Plague Ward can neutralize them without putting themselves at risk of receiving Poison Sting: Arc Warden, Chen, Clinkz, 
Drow Ranger, Lina, Mirana, Nature's Prophet, Pugna and Sniper.
* Special mention to heroes that outrange Plague Ward after obtaining talents that increase attack range.
Viper
* Heroes with damage-increasing passive abilities, such as Viper and Riki, will usually kill Silencer in a short time before he even has time to set up his abilities.
Viper
* Melee heroes with low mobility can be kited and killed by Viper: Treant Protector, Kunkka, Alchemist, Troll Warlord, Wraith King, Tiny, Sven.
Viper
* Heroes who can harass Omniknight out of lane will keep him weak in the mid game: Viper, Venomancer, Clinkz.
Chen
* Heroes that can easily bypass Chen's creeps to get to Chen: Riki, Tusk, Clinkz, Sniper, Slark, Phantom Assassin, Void Spirit, Storm Spirit, Ember Spirit, Earth Spirit, Spirit Breaker.
Viper
* Viper Strike breaks Sniper's passives.
* Corrosive Skin allows Viper to deal more damage to Sniper than Sniper deals to him when laning, especially by briefly stepping into Shrapnel.
* Nethertoxin together with Poison Attack can slow Sniper and tears through his low health and mobility.
Chen
* Heroes with strong area-of-effect damage can make quick work of Chen's converted creeps and at same time gain farm: 
Magnus, Jakiro, 
Shadow Fiend, Kunkka, Luna, 
Dragon Knight, 
Medusa, Alchemist.
Viper
* In the early game, a Dragon Knight without Black King Bar is basically defenseless against Viper.
* Viper can harass Dragon Knight at any time with his Poison Attack and Nethertoxin.
* Corrosive Skin reduces damage from Dragon Fire and inflicts damage to him.
* Viper Strike disables Dragon Blood, negating his main survivability.
* Viper Strike and Poison Attack can severely slow him down even with his Elder Dragon Form.
Additional:
* Dragon Knight is easily harassed by Poison Attack after the laning stage ends.
* Corrosive Skin protects Viper from 
Breathe Fire and returns damage.
* Viper Strike can disable 
Dragon Blood, Dragon's Knight main source of armor and health regeneration.
* Between Poison Attack and Viper Strike, Viper can keep Dragon Knight permanently slowed even in 
Elder Dragon Form.
Viper
* Heroes that can drain mana negatively affect Viper's ability to use Poison Attack, Nethertoxin and Viper Strike: Lion, Anti-Mage
Viper
* Viper's skill set makes him an effective early game ganker against Anti-Mage before he is sufficiently farmed.
* Viper's Corrosive Skin and low mana pool causes him to take little damage from Mana Void.
* Nethertoxin disables Mana Break and Counterspell, weakening both his offense and defense.
Chen
* Heroes with channeling spells, for Chen has no disables on his own, hates buying disabling items and his creeps are often not fast enough to cancel them: Enigma's Black Hole, Witch Doctor's Death Ward, Shadow Shaman's Shackles, Lion's Mana Drain, Bane's Fiend's Grip, Pudge's Dismember, Crystal Maiden's Freezing Field, Pugna's Life Drain, Dawnbreaker's Solar Guardian, and Naga Siren's Reel In from Aghanim's Scepter.
Chen
* 
Rot is not very effective against Chen's creeps.
* Chen can use his creeps to cover him or his allies from any attempts of 
Meat Hook.
* {U:Centaur Conqueror} or {U:Mud Golem} under Chen's control can interrupt Dismember.
Chen
* Heroes that can easily bypass Chen's creeps to get to Chen: Riki, Tusk, Clinkz, Sniper, Slark, Phantom Assassin, Void Spirit, Storm Spirit, Ember Spirit, Earth Spirit, Spirit Breaker.
Additional:
* Chen is basically Riki's natural prey: he has little HP, low armor and relies on his persuaded creeps to fight, which in most situations will not save Chen from Riki. Just be wary of {U:Centaur Conqueror}, who can stun Riki outside of Smoke Screen and ruin his attempt at Chen's life.
Viper
* Viper's Nethertoxin disables 
Cloak and Dagger, negating Riki's invisibility and much of his damage. It also makes him more vulnerable to magic damage, which does not go well with Riki's low health pool. With the talent applied, he can't even blink to safety or hide with Tricks of the Trade.
* Corrosive Skin makes it hard for Riki to chase Viper and attack him due to the attack speed slow.
* Viper Strike stays on Riki even after he goes invisible.
* Poison Attack makes it risky for Riki to get last hits and can make the laning phase difficult for him.
Chen
* Heroes with either magical, physical or pure damage burst can often kill Chen or his allies before he can use Hand of God: Lina, Luna, 
Techies, Shadow Fiend, Pugna, Nyx Assassin.
Viper
* Corrosive Skin minimizes the damage from 
Impale and 
Mind Flare, and anything else Nyx Assassin tries to throw at Viper.
* Nyx Assassin cannot survive several poison damage-over-time output from Poison Attack, Nethertoxin, Corrosive Skin and Viper Strike, not even while he has 
Spiked Carapace active. And to make things worse, Nyx Assassin is not a common Silver Edge wielder to counter this problem at all.
Additional:
* Corrosive Skin minimizes the damage from Impale and Mind Flare, and anything else Nyx Assassin tries to throw at Viper.
* Nyx Assassin cannot survive several poison damage-over-time output from Poison Attack, Nethertoxin, Corrosive Skin and Viper Strike, not even while he has Spiked Carapace active. And to make things worse, Nyx Assassin is not a common Silver Edge wielder to counter this problem at all.
Chen
* Heroes that can easily bypass Chen's creeps to get to Chen: Riki, Tusk, Clinkz, Sniper, Slark, Phantom Assassin, Void Spirit, Storm Spirit, Ember Spirit, Earth Spirit, Spirit Breaker.
Viper
* Poison Attack makes it hard for Void Spirit to lane against him.
* Corrosive Skin reduces the magical damage from Void Spirit's spells.
Chen
* Doom can easily kill Chen's creeps and obtain their abilities with 
Devour.
* 
Scorched Earth's area-of-effect can clear multiple of Chen's creeps at once.
* 
Doom renders Chen completely helpless, and unable to save himself or his allies with Hand of God. Aghanim's Scepter upgraded Doom also allows Doom to cast Doom on himself and disable both, Chen and his creeps around him.
Viper
* The slow applied from Corrosive Skin offsets the movement speed bonus granted by Scorched Earth and the tick-based damage from Infernal Blade and Doom will continually slow Doom down. This allows Viper, much like Sniper, to 'kite' Doom and keep him at a safe distance between the two. Additionally, Corrosive Skin applies an attack-speed slow which is fairly crippling to a hero such as Doom that, naturally, has a high base attack-time, poor agility gain and builds little attack-speed items.
* Since Doom does not disable auto-cast abilities, Viper's Poison Attack will continue to work. Doom may find it hard to close the distance between himself and Viper, and thusly difficult to effectively lockdown and continually deal damage through his abilities.
Chen
* Monkey King can kill Chen or any of his allies with his physical damage burst from 
Boundless Strike and 
Jingu Mastery before he can use Hand of God.
* None of the neutral creeps have any abilities to destroy trees, which makes Chen an excellent target for ganks with 
Tree Dance and 
Primal Spring.
Viper
* Nethertoxin prevents the buildup of Jingu Mastery stacks.
* Viper's poison magical damage-over-time stops Monkey King from using Tree Dance. It also ignores the extra armor bestowed by Wukong's Command.
Additional:
* Viper STrike prevents the buildup of Jingu Mastery stacks.
* Monkey King's high base movement speed is of little worth against the array of slows Viper possesses.
* All of Viper's magical damage over time stops Monkey King from using Tree Dance. It also ignores the extra armor bestowed by 
Wukong's Command.
Chen
* Techies can easily catch Chen off guard and kill him quickly with 
Blast Off! and 
Ethereal Blade combo, especially because Blast Off! can silence Chen and stun him when upgraded with Aghanim's Shard.
* However, Chen's converted creeps can trigger 
Proximity Mines, wasting them.
Viper
* Corrosive Skin will protect Viper from Techies' magical damage.
* Even though Reactive Tazer will disarm Viper if he attacks Techies with Poison Attack, he does lots of damage with his other abilities that can still kill Techies.
Chen
* Lina's high damage burst from 
Dragon Slave, 
Light Strike Array and 
Laguna Blade can easily kill Chen's allies or Chen himself before he can use Hand of God.
Additional:
* Lina's high damage burst from Dragon Slave, Light Strike Array and Laguna Blade can easily kill Chen's allies or Chen himself before he can use Hand of God.
Viper
* Viper Strike prevents buildup of Fiery Soul stacks.
* Corrosive Skin provides magic resistance against Lina's spells. However, Lina can counter this with Silver Edge, a common item on Lina.
* Poison Attack and Viper Strike can burn away Lina's small health pool.
Chen
* Heroes that can easily bypass Chen's creeps to get to Chen: Riki, Tusk, Clinkz, Sniper, Slark, Phantom Assassin, Void Spirit, Storm Spirit, Ember Spirit, Earth Spirit, Spirit Breaker.
Viper
* Heroes with Break abilities will prevent Slark from regenerating and gaining Essence Shift stacks: Viper, Shadow Demon, etc.
Additional:
* Viper Strike can disable 
Essence Shift and the regeneration aspect of 
Shadow Dance.
* 
Dark Pact doesn't mean a lot against Viper's ubiquitous slows.
* Viper becomes a relevant presence in team fights before Slark can procure his standard items (e.g. 
Shadow Blade).
Chen
* Razor's 
Plasma Field and the passive from 
Eye of the Storm can damage and clear Chen's creeps.
* Chen has no escape mechanisms, making him easy prey for 
Static Link, which can also minimalize effects of Penitence.
* Eye of the Storm will rapidly strike Chen's creeps around Razor.
Viper
* Viper's Poison Attack and Viper Strike that can slow Razor, and is one of the few heroes that can keep him immobile.
* Altogether, Viper's skills reduce Razor's attack speed, heavily reducing the benefit of the damage drain from Static Link.
Additional:
* 
Storm Surge is counteracted by Viper Strike, leaving Razor without his extra movement speed.
* Static Link's damage drain doesn't bother Viper a lot as most of his early to mid game damage is magical.
Chen
* With 
Timber Chain, Timbersaw can slow, catch up with, or escape from Chen and his creeps.
* 
Chakram and 
Flamethrower from Aghanim's Shard can clear Chen's creeps and slow him.
* Attacks from multiple creeps will quickly build 
Reactive Armor stacks, making attacks of Chen and his creeps only tickle Timbersaw.
Viper
* Viper Strike prevents Timbersaw from gaining stacks on Reactive Armor.
Viper
* 
Ice Wall and 
Ghost Walk can be used to kite and escape from Viper.
* 
Chaos Meteor and 
Sun Strike deal heavy damage and can quickly bring Viper down.
* 
Cold Snap, 
Tornado, and 
Deafening Blast are powerful disables that reduce Viper's effectiveness.
* 
E.M.P. burns Viper's limited mana pool, reducing his potential poison damage.
* 
Forge Spirits can melt Viper's armor and reduce his durability.
Viper
* Corrosive Skin makes Viper receive less damage from Invoker's spells
* Viper can harass Invoker with his Poison Attack in the early game.
* Viper Strike and Poison Attack can kill Invoker easily if Ghost Walk is on cooldown.
Chen
* 
Echo Slam will deal immense damage due to the amount of creeps Chen will have.
* 
Fissure and 
Enchant Totem deal large amounts of AOE damage, wearing down non-ancient creeps that Chen converts.
Viper
* Poison Attack and Viper Strike allowing to kite and slow Earthshaker significally, putting Blink Dagger on cooldown and preventing him from initiating or re-initiating.
* Nethertoxin breaks Aftershock. The silence from Level 25 talent also prevents Earthshaker from initiating or re-initiating.
Additional:
* Being a melee hero, Earthshaker's movement is liable to suppression by Poison Attack and Viper Strike.
* Earthshaker's kit, with the exception of Enchant Totem, deals magic damage. Corrosive Skin effectively blunts his killing potential with a standard Blink combo among other things.
* Viper Strike can disable 
Aftershock, which removes the stun and bonus damage from Enchant Totem and Echo Slam.
Chen
* Heroes that can easily bypass Chen's creeps to get to Chen: Riki, Tusk, Clinkz, Sniper, Slark, Phantom Assassin, Void Spirit, Storm Spirit, Ember Spirit, Earth Spirit, Spirit Breaker.
Viper
* Heroes that can slow Charge of Darkness by a huge amount: Venomancer, Viper, 
Dazzle, Arc Warden, Lion, 
Huskar, Shadow Shaman, Visage, 
Undying, Jakiro.
Chen
* Heroes that can easily bypass Chen's creeps to get to Chen: Riki, Tusk, Clinkz, Sniper, Slark, Phantom Assassin, Void Spirit, Storm Spirit, Ember Spirit, Earth Spirit, Spirit Breaker.
Viper
* Heroes that can apply early pressure before Phantom Assassin has farm are massive threats: 
Axe, Viper, Meepo, Jakiro, Pugna, Slark, Venomancer etc.
Chen
* Heroes with strong area-of-effect damage can make quick work of Chen's converted creeps and at same time gain farm: Magnus, Jakiro, Shadow Fiend, Kunkka, Luna, Dragon Knight, Medusa, Alchemist.
Viper
* Any hero who can survive Magnus's initiations and manfight him: Huskar, 
Faceless Void, 
Weaver, 
Abaddon, Troll Warlord, Alchemist, Dragon Knight, 
Night Stalker, Viper.
Additional:
* Most of Magnus's abilities except 
Empower will trigger damage through Corrosive Skin.
* Poison Attack and Viper Strike can slow Magnus during 
Skewer, as well as putting his Blink Dagger on cooldown, preventing him from initiating or re-initiating.
Chen
* 
Spectral Dagger can severely slow down Chen and allow Spectre to chase him down.
* Spectre often buys Radiance, which allows her to clear waves of Chen's creeps and if Chen has no creeps beside himself, he will suffer serious damage from 
Desolate.
* 
Dispersion will make attacks from Chen's creeps only tickle Spectre while also killing themselves in process.
* 
Haunt can find Chen anywhere on the map, no matter where he is.
Viper
* Nethertoxin disable passives, negating Spectre's damage and survivability by removing both Dispersion and Desolate.
* Due to Haunt and Radiance's burn, Spectre is heavily susceptible to being persistently slowed and damaged by Corrosive Skin without even directly attacking Viper.
* Poison Attack and Viper Strike further slow Spectre's movement speed to a crawl, while his improved magic resistance means he can easily shrug off Radiance's burn.
Additional:
* Viper Strike can disable Desolate and Dispersion, leaving Spectre with far less damage output and damage mitigation in engagements.
* Spectre is one of the weakest heroes at early levels. Viper can stifle her farm with early fights before Spectre purchases any major items.
Chen
* 
Heartstopper Aura can do a decent damage overtime to Chen's High-Health-Creep Army, and Chen does not have any source of burst damage to fight back against Necrophos.
* Skilled Necrophos can purchase a 
Spirit Vessel to provide an AOE debuff that can reduce the healing from 
Divine Favor and Hand of God.
* Necrophos often builds Radiance, which combined with 
Death Seeker from Aghanim's Shard allows him to quickly clear Chen's creeps.
* Necrophos can often kill Chen's allies with 
Reaper's Scythe before Chen can save them with Hand of God.
Viper
* Viper does large amounts of magic damage over time, meaning that if a Necrophos uses Ghost Shroud, Viper's abilities will greatly reduce Necrophos survivability, and may actually kill him.
* By the same token, Viper can use his Viper Strike on Necrophos if he attempts to heal himself with Ghost Shroud, and depending on any other effects Necrophos may have from him, (IE:Poison Attack,Corrosive Skin), Viper can often kill Necrophos while he is in his Ghost Shroud.
* Viper's Corrosive Skin helps him take reduced damage from all of Necrophos spells that deal magical damage, which is his only source of damage.
Additional:
* Viper Strike prevents Heartstopper Aura from dealing damage or healing Necrophos.
* Viper's magic damage is amplified whenever 
Ghost Shroud is used.
* Corrosive Skin makes Viper tankier against 
Death Pulse and Reaper's Scythe.
Chen
* 
Shadowraze can clear waves of Chen's creeps while giving Shadow Fiend gold and damage for 
Necromastery.
* 
Requiem of Souls's very high magical damage can often kill Chen and his creeps or his allies before he can save them with Hand of God.
Viper
* Nethertoxin both Necromastery and Presence of the Dark Lord, reducing his damage massively.
* Corrosive Skin gives Viper bonus Magic Resistance against Shadowraze and Requiem of Souls.
* Viper can easily take advantage of Shadow Fiend's lack of escape and mobility spells with Viper Strike breaks and Poison Attack. Poison Attack also serves as a great way to harass Shadow Fiend.
Chen
* Phoenix's large damage over time with 
Icarus Dive and 
Fire Spirits can kill Chen's allies before he can use Hand of God.
* Phoenix naturally buys Spirit Vessel, which allows him to reduce healing from Divine Favor and Hand of God.
* Phoenix's 
Supernova cannot be damaged by Chen's creeps, and their normal speed means they will often not be able to kill Phoenix whenever he uses Supernova.
Additional:
* Not only Phoenix is able to disrupt Chen's jungling with Fire Spirits, but its high damage over time can also force Chen to use Hand of God prematurely, potentially wasting any chance to save his allies during teamfights.
* Creeps' damage and attack speed are very abysmal, so Chen often cannot kill Phoenix whenever it casts Supernova.
Viper
* Corrosive Skin gives Viper additional resistance to Phoenix's magical damage, and since they deal damage over time, Phoenix would be constantly afflicted by his passive's own debuff, making him not an ideal target for Phoenix's harassment. Phoenix's abilities also constantly drain its own health away, becoming more vulnerable to Poison Attack.
Chen
* 
Inner Fire can damage and disarm Chen's creeps.
* 
Burning Spear's high damage over time that grows stronger the more it stacks can force Chen to use Hand of God prematurely, potentially wasting a chance to save his allies during a teamfight.
* 
Berserker's Blood makes it impossible for Chen and his creeps to kill Huskar.
* 
Life Break can deal huge damage to Chen and slow him down.
Viper
* His Poison Attack is very useful against Huskar, since he tends to stay at low health.
* Nethertoxin disables passive skills like Berserker's Blood.
* It is dangerous for Huskar to jump on Viper because Corrosive Skin and Viper Strike with the slowdown of movement and attack speed which usually will be deadly for Huskar.
Additional:
* Viper Strike can disable Berserker's Blood, which Huskar relies upon for attack speed and healing.
* The damage from Burning Spear and Life Break is largely absorbed by Corrosive Skin. It also will return some damage, making it risky to use Burning Spears in the laning stage.
* Because Huskar wants to be on low health for Berserker's Blood, he is particularly vulnerable to Poison Attack.
Chen
* Axe can take advantage of Chen jungling and gank him more often with Blink Dagger and 
Berserker's Call combination.
* 
Counter Helix can clear waves of Chen's creeps if they are too close to Axe.
* Berserker's Call combined with 
Blade Mail and 
Culling Blade can often kill Chen before he can save himself with Hand of God.
* However, Hand of God and Divine Favor can make it hard for Axe to finish off Chen's allies with Culling Blade when Chen is not target for Axe.
Viper
* Poison Attack and Viper Strike slows Axe significantly, and puts his Blink Dagger on cooldown, preventing him from initiating. Viper Strike can also break from Counter Helix.
Additional:
* Viper Strike prevents Counter Helix from triggering, which significantly lowers Axe's damage output in the early to mid game.
* Viper's various slows and damage over time prevents Axe from initiating as well as putting his Blink Dagger on cooldown.
Chen
* 
Starbreaker can deal huge damage to Chen and clear waves of his creeps.
* 
Celestial Hammer can deal damage over time to both, Chen and his creeps, which may force Chen to use Hand of God prematurely.
* Solar Guardian allows Dawnbreaker to counter Chen's pushing attempts and to rejoin her team with Solar Guardian when they require it. Aghanim's Scepter upgraded Solar Guardian can also give Dawnbreaker's allies evasion while Dawnbreaker is airborne for it's duration, wasting much of Penitence's power.
Additional:
* Starbreaker can deal huge damage to Chen and clear waves of his creeps.
* Celestial Hammer can deal damage over time to both, Chen and his creeps, which may force Chen to use Hand of God prematurely.
* Solar Guardian allows Dawnbreaker to counter Chen's pushing attempts and to rejoin her team with Solar Guardian when they require it. Aghanim's Scepter upgraded Solar Guardian can also give Dawnbreaker's allies evasion while Dawnbreaker is airborne for it's duration, wasting much of Penitence's power.
Viper
* Nethertoxin disables Dawnbreaker's 
Luminosity. Since she's a melee hero, she needs to close gap to attack and Nethertoxin will be bad for her since she cannot heal.
* Viper Strike and Poison Attack will severely slow her down and combined with Nethertoxin, it will be her death sentence (unless her Celestial Hammer or Solar Guardian are off cooldown). Besides that, chasing her down will be easy due to the slow.
Chen
* Ice Blast prevents Divine Favor and Hand of God from healing his allies or himself.
Additional:
* 
Ice Blast can prevent healing from Hand of God and kill Chen's creeps.
* Ancient Apparition can easily harass Chen on lane with 
Chilling Touch due to it's high range and damage. This can get even worse if Ancient Apparition buys Aghanim's Scepter and combines it with items that can give him bonus attack damage and attack speed.
* Chilling Touch combined with 
Ice Vortex makes it impossible for Chen to escape from 
Cold Feet. Ice Vortex can also make Chen's creeps more vulnerable to Ancient Apparition and his allies's magical damage.
Viper
* Corrosive Skin minimizes the damage Viper takes from all of Ancient Apparition's abilities.
* Ancient Apparition's slow movement speed, squishy nature, and lack of escape abilities can easily be taken advantage of through Poison Attack and Viper Strike.
Chen
* 
Earthshock can slow down Chen and deal damage to both, Chen and his creeps.
* Many stacks from 
Fury Swipes combined with 
Overpower can guaranatee a kill for Ursa before Chen can save his allies with Hand of God.
* 
Enrage only makes Chen's attacks and his creeps's attacks tickle Ursa.
Viper
* Viper Strike is a strong and breaks Fury Swipes, undispellable slow, making it much easier to kite Ursa for everyone.
Chen
* 
Magic Missile can stun Chen and deal heavy damage to him.
* 
Wave of Terror weakens durability of Chen and his creeps.
* 
Nether Swap can be used to separate Chen away from his creeps, often to certain death from Vengeful Spirit's allies.
Viper
* Nethertoxin disables Vengeance Aura.
* Vengeful Spirit has no mobility spells aside from Nether Swap, which Viper can take advantage of with his slows.
* Viper can easily bully Vengeful Spirit out of a lane with Poison Attack.
Additional:
* Viper Strike can disable the attack damage bonus from 
Vengeance Aura and the components of Nether Swap.
* Both Magic Missile and Wave of Terror are counteracted by Corrosive Skin, making Vengeful Spirit's fighting harder against Viper.
Viper
* Ranged heroes will have a hard time hitting enemies inside Magnetic Field: 
Silencer, Viper.
Chen
* Heroes with summons or illusions can counter Flux, such as Beastmaster , Chen, or Shadow Demon.
Additional:
* Chen in the early game is a faster pusher than Arc Warden until Arc Warden buys Maelstrom.
Chen
* Heroes with strong area-of-effect damage can make quick work of Chen's converted creeps and at same time gain farm: Magnus, Jakiro, Shadow Fiend, Kunkka, Luna, Dragon Knight, Medusa, Alchemist.
Viper
* Melee heroes with low mobility can be kited and killed by Viper: Treant Protector, Kunkka, Alchemist, Troll Warlord, Wraith King, Tiny, Sven.
Chen
* 
Grave Chill can heavily slow down Chen and boost Visage and his familiars's attack speed and movement speed.
* Chen's Holy Persuasion cannot convert Visage's familiars from 
Summon Familiars at all, not even when upgraded with Aghanim's Shard that allows Chen to use it on ancient creeps as Visage's familiars are treated as creep-heroes, which could put Chen in disadvantage against Visage if his creeps die.
* Skilled Visage can buy Bloodthorn to prevent Chen from any chance of retaliating or saving himself with Hand of God and Gleipnir to clear waves of Chen's creeps and prevent them from escaping. This can get even better if Visage has access to 
Silent as the Grave ability from Aghanim's Scepter that will allow Visage and his familiars to be invisible, which they can use either to escape from Chen or to prepare a deadly surprise to him.
Viper
* Viper Strike can disable 
Gravekeeper's Cloak, Visage's primary defense mechanism.
* Viper can ignore Grave Chill's attack speed slow with his magic damage output.
Additional:
* Since Visage is a slow hero, Viper can easily kite him with Poison Attack and Viper Strike while successfully chipping away at Gravekeeper's Cloak.
* Nethertoxin removes all layers of Gravekeeper's Cloak, leaving Visage exposed.
* Corrosive Skin makes Viper highly resistant to Soul Assumption.
Chen
* 
Track allows Bounty Hunter to keep Chen under watch whenever he jungles and to give Bounty Hunter and his allies a huge gold gain whenever Chen is killed while under effects of Track.
* 
Shadow Walk allows Bounty Hunter to bypass Chen's creeps and sneak on Chen and finish him off with 
Jinada and 
Shuriken Toss.
* However, Bounty Hunter's single-targeted ability arsenal can make it difficult for him to clear waves of Chen's creeps.
Viper
* Viper's poison abilities can slow Bounty Hunter's movement speed and allows to chase him with True Sight items.
* Nethertoxin can break Jinada, and the silence from level 25 prevents Bounty Hunter from using all of his spells.
Chen
* Aphotic Shield can nullify Chen's combo, while clearing Chen's creeps simultaneously.
Viper
* Because Poison Attack has almost no cooldown, Aphotic Shield is ineffective as a hard dispel.
* Viper Strike can prevent 
Borrowed Time from activating passively and block 
Curse of Avernus.
Additional:
* Because Poison Attack has almost no cooldown, 
Aphotic Shield is ineffective as a hard dispel.
* Viper Strike can prevent Borrowed Time from activating passively and block Curse of Avernus.
Viper
* Viper is an agility hero, and his item build mostly includes agility items, so Natural Order can be devastating, removing all armor and greatly decreasing the effectiveness of
Corrosive Skin, weakening Viper's magic resistance. Additionally, Echo Stomp and Earth Splitter deal both magical and physical damage, and can help bringing Viper down fast.
Aghanim's Scepter may be necessary to take Viper down due to 
Nethertoxin's break.
*
Chen
* Elder Titan's
Astral Spirit ability gives him bonus damage for each converted creep it passes through.
Echo Stomp and 
Earth Splitter will often kill him or any of his allies quickly before he has time to use Hand of God.
*