Warlock
* Because Warlock's abilities are all active abilities, Silencer can make his impact minimal.
* 
Arcane Curse prevents Warlock from using his abilities without increasing it's duration, which since all of Warlock's abilities are actives it is very effective against him.
* 
Last Word can prevent Warlock from casting his Fatal Bonds, Chaotic Offering, and Upheaval combo.
* 
Global Silence can nullify Warlock's impact in fights by preventing him from casting Fatal Bonds and Chaotic Offering, or by interrupting his Upheaval.
Medusa
* Silencer burns easily through her effective HP from 
Mana Shield, by taking away her intelligence.
* Arcane Curse punishes her repeatedly casting 
Mystic Snake to keep her mana pool high. He can force her to use 
Manta Style before he has cast Global Silence and 
Medusa usually does not want to build 
Black King Bar.
Warlock
* 
Upheaval does not interrupt Slark too much, as he can just Pounce out of the area.
* 
Fatal Bonds and 
Shadow Word can be dispelled by Dark Pact.
Medusa
* Medusa is especially vulnerable to 
Essence Shift, as both strength and intelligence contribute to her effective HP, while agility contributes to her damage.
* 
Dark Pact when timed right can be used to dispel Stone Gaze right after it petrifies Slark, allowing him to keep attacking Medusa throughout the duration.
Additional:
* Medusa cannot chase Slark in any way and has no disable beyond her ultimate, making her unable to stop him getting away and regenerating before coming back to finish her off.
* Essence Shift particularly removes 1 intelligence point per hit, thus lowering Medusa's mana pool's cap and leaving her much more vulnerable in prolonged fights.
Warlock
* 
Mana Break prevents Warlock from casting his spells, particularly in the laning phase.
* 
Blink allows Anti-Mage to escape from Upheaval.
* 
Counterspell reduces damage from Shadow Word and Warlock's Golem's 
Permanent Immolation passive. Additionally, it can reflect Shadow Word and Fatal Bonds.
* 
Mana Void deals heavy damage after Anti-Mage has drained Warlock's large mana pool.
Medusa
* Anti-Mage easily destroys Mana Shield with Mana Break, especially once he has Manta Style.
* Anti-Mage effectively avoids 
Stone Gaze with Blink, and can reinitiate after its duration is over.
Additional:
* Mana Break burns Medusa's mana easily, especially when coupled with a Manta Style.
* Can easily initiate on Medusa with Blink, burning her mana or forcing her to use Stone Gaze.
* Mana Void is effective against Medusa's big mana pool and mana usage, presenting a huge hazard to Medusa's allies around her since her Mana Shield still gives her some protection if she has mana.
Warlock
* Warlock is a very strong hero when positioned correctly, and his long cast range helps him with this. However, some Heroes might disrupt or sneakily pass through his allies and deal with him, preventing him from doing his job. Such heroes include 
Chaos Knight, 
Spirit Breaker, 
Riki, and more.
Medusa
* With 
Smoke Screen, Riki will silence and catch Medusa in a surprise with high miss chance flushing her from positions easily in team fights.
* He can deal a huge amount of damage through 
Cloak and Dagger, even through Mana Shield.
Warlock
* 
Ursa can shred Warlock's Golems in a few seconds with 
Fury Swipes and 
Overpower.
Medusa
* Ursa's status resistance from 
Enrage reduces duration of Medusa's Stone Gaze.
* Ursa can stack damage with Fury Swipes easily against her Mana Shield in a prolonged team match.
Additional:
* Medusa's tankiness doesn't help her very much against Fury Swipes in long teamfights.
* With no escape mechanism and a slow movement speed, getting jumped on by Ursa usually spells a quick end for Medusa in the early game.
Warlock
* Ghostship helps your team soak up damage from 
Chaotic Offering and hit summons hard.
* Tidebringer clears summons later in the game.
* Most of your spells can interrupt Upheaval.
Medusa
* He can use either his own or his double's 
Flux to bypass the spellblock from Linken's Sphere, using the leftover Flux + 
Spark Wraith to slow Medusa's already low move speed to a crawl.
* Arc Warden has a farming advantage with double 
Hand of Midas, and can generally bully Medusa with other items that benefit from duplication.
Medusa
* Phantom Lancer with 
Diffusal Blade will very quickly burn Medusa's mana, making Mana Shield significantly less effective.
* 
Doppelganger's 1 second invulnerability can be used to dodge Medusa's petrification from Stone Gaze, as well as Mystic Snake.
* Phantom Lancer's illusions outnumber Medusa's targets from Split Shot, likely shielding his team in the process.
Medusa
* E.M.P. allows Invoker to burn Medusa's mana to weaken Mana Shield.
* Medusa's lack of mobility makes her easy to kite with Invoker's spells.
Additional:
* 
E.M.P. is a large mana burn nuke which can hit Medusa's Mana shield with enough damage to lose even more mana.
* 
Deafening Blast disarms Medusa's ability to deal pseudo-AOE damage during teamfights.
* 
Cold Snap allows the opposing team to repeatedly stun Medusa in short succession, preventing her from successfully casting her ultimate due to its long cast time.
Medusa
* Webbed areas can be used to hit and run, covering distance hastily weakening her on the way and initiating ganks.
* Even though Medusa can hunt down Spiderlings easily when given enough range, 
Silken Bola will cause her attacks to miss and get her swarmed in no time.
* Medusa usually does not build a Black King Bar to benefit from Mana Shield fully while Broodmother can fit a Diffusal Blade to burn away all of Medusa's mana.
Additional:
* 
Spin Web will allow Broodmother to pick her own fights and sometimes slip away to ambush Medusa.
* Though Medusa's Split Shot and Mystic Snake can help Medusa deal with Broodmother's spiderlings, Broodmother will create too much of them for her to handle, allowing her to outnumber Medusa's targets from Split Shot and shield her team in process.
Warlock
* 
Ice Blast cancels Warlock's Golem's and Shadow Word's healing.
* 
Cold Feet stuns Warlock if he stands in place, forcing him to stop channeling Upheaval immediately or be forced to stop channeling it by it's stun.
Warlock
* Weaver's 
Shukuchi allows him to escape from Warlock's Upheaval with high move speed.
* 
Time Lapse allows Weaver to ignore damage from Warlock's Golem and escape.
Medusa
* Sniper can outrange both Medusa's arrows and Stone Gaze, allowing him to focus her down during a teamfight.
Additional:
* Medusa is a fairly immobile hero that deals damage around her with 
Split Shot. Sniper should outrange her and should stay out of harm's way from Split Shot.
* More importantly, Sniper should have enough attack range to fire at Medusa during her Stone Gaze without turning to stone, so the ultimate is mostly wasted against him.
Medusa
* With 
Static Link, Razor can effectively make Medusa useless in teamfights by reducing her main damage output. It can, however, be blocked by a 
Linken's Sphere.
* 
Plasma Field allows Razor to get on top of Medusa, slowing her already slow movement speed to a mere crawl.
* 
Eye of the Storm capitilizes on Medusa's low armor and causes her to be very vulnerable, even through Mana Shield.
Warlock
* A pre-placed 
Fire Remnant allows Ember Spirit to escape Upheaval.
* 
Flame Guard blocks Shadow Word's damage.
* 
Sleight of Fist allows Ember Spirit to attack from outside of Upheaval's range, and 
Searing Chains lets him interrupt it.
Warlock
* Spell Steal can easily stealing from Chaotic Offering is a better position. Build 
Aghanim's Scepter and 
Octarine Core make cooldown reduction abilities from Rubick and addition instanly Warlock's Golem from Chaotic Offering stollen.
* Telekinesis from Rubick can help stopped from Upheaval chancelled. Telekinesis also stopped from Upheaval with throw creeps and enemy hero touch down to Warlock. Rubick's can build 
Aghanim's Shard save the his allies trapped from Upheaval.
* Upheaval can stollen for Rubick passing positionning area from Upheaval. Alternative, already from Chaotic Offering via Spell steal also possible cancelled from Upheaval with ready build Aghanim's Scepter capable of stealing two abilities from Warlock's.
* Shadow Word stollen for Rubick can very helpful restore health from his allies. Addictionally, for Shadow Word stollen can reduction health from enemy heroes.
* Fatal Bonds makes Rubick simplify fighting from target.
Additional:
* 
Spell Steal can perfect steals all abilities for Warlock primarily Chaotic Offering.
* Rubick always purchase Aghanim's Scepter will additionally Rubick's instanly Chaotic Offering stolen although Warlock's without purchase Aghanim's Scepter.
* 
Telekinesis can cancelled Upheaval lift up Warlock's and also can cancel from Upheaval with nearby creeps and enemy hero from Telekinesis can throw and touch down to Warlock's. Additionally, Telekinesis can save allies from Upheaval trap will upgrade with Aghanim's Shard .
Warlock
* Warlock is a very strong hero when positioned correctly, and his long cast range helps him with this. However, some Heroes might disrupt or sneakily pass through his allies and deal with him, preventing him from doing his job. Such heroes include Chaos Knight, Spirit Breaker, Riki, and more.
Warlock
* Heroes with channeling spells are very easy targets for Jakiro's abilities: 
Crystal Maiden, 
Dawnbreaker, 
Enigma, 
Pudge, 
Shadow Fiend, 
Shadow Shaman, 
Warlock.
Warlock
* Heroes that rely on summons will suffer against Ion Shell, which kills them very quickly: 
Beastmaster, 
Broodmother, Enigma, 
Nature's Prophet, 
Visage, Warlock, 
Wraith King.
Additional:
* 
Surge allows for Dark Seer and his allies to escape from Upheaval due to it ignoring any slow.
Medusa
* Heroes that build Diffusal Blade or can fit it well into their item build will also make Medusa much less tanky: Riki, 
Naga Siren, 
Terrorblade, 
Juggernaut, 
Spectre, 
Slark.
Medusa
* Hard carries who just want to farm and be left alone will not appreciate Primal Beast, heroes such as Medusa, 
Drow Ranger...
Warlock
* Because all of Warlock's abilities are active abilities, silences can make his impact in fights minimal. Be cautious of heroes that carry silences like 
Death Prophet, 
Puck, and the aforementioned 
Silencer.
Medusa
* Other heroes who has armor and slow debuffs won't allow Medusa to disengage from combat: 
Tidehunter, 
Bristleback, 
Slardar.
Medusa
* Heroes who take a long time to become strong are in for a rough mid game, such as 
Outworld Destroyer, 
Magnus, Medusa, and 
Anti-Mage.
Warlock
* Because all of Warlock's abilities are active abilities, silences can make his impact in fights minimal. Be cautious of heroes that carry silences like Death Prophet, Puck, and the aforementioned Silencer.
Medusa
* Heroes with extremely slow movement speed will cripple against Solar Bind: Medusa, 
Viper
Additional:
* 
Will-O-Wisp will keep Medusa busy after she got hit by 
Blinding Light.
Medusa
* Other heroes who has armor and slow debuffs won't allow Medusa to disengage from combat: Tidehunter, Bristleback, Slardar.
Medusa
* Heroes that build Diffusal Blade or can fit it well into their item build will also make Medusa much less tanky: Riki, Naga Siren, Terrorblade, Juggernaut, Spectre, Slark.
Medusa
* Fiend's Grip provides mana drain, which can heavily damage Mana Shield and prevent Medusa from using Stone Gaze.
* Even if she does use Stone Gaze, Nightmare can buy enough time to protect allies and reset the fight.
Additional:
* 
Fiend's Grip leaves Medusa defenseless, since not only does it deal damage, it also drains mana.
Warlock
* Heroes with illusions and summons can swarm Bane, who has no area abilities outside from Aghanim's Shard upgraded 
Brain Sap: Broodmother, Chaos Knight, Naga Siren, Nature's Prophet, 
Phantom Lancer, Terrorblade, Visage, Warlock, Wraith King.
Medusa
* Medusa lacks mobility or escape mechanisms. 
Earth Spike and 
Hex can neutralize her strong damage potential and allow for 
Lion's team to focus her down.
* In addition to easily breaking her commonly bought Linken's Sphere with its low cooldown, 
Mana Drain can quickly drain her Mana Shield, making her far less tanky.
* Mana Drain, along with Hex, destroy illusions instantly, which may be extremely helpfull and efficient against core builders of Manta Style, like Medusa herself.
Warlock
* While heroes with strong mobility are able to get close or flee from Upheaval, heroes with no escaping abilities or that lack long disables will perish against Warlock. Once the Warlock Golem lands with its stun, its hardly possible to escape when he casts Upheaval. Notable examples: 
Huskar, Drow Ranger, Lion, 
Elder Titan, etc.
Medusa
* 
Bulwark can make each of Medusa's attacks target him instead, reducing Medusa's contribution on team fights.
* 
Spear of Mars stuns Medusa and also pushes her away from teamfights, taking advantage of Medusa's low mobility.
* 
Arena Of Blood blocks Medusa's attacks from outside the arena.
Medusa
* Medusa's Stone Gaze forces Mars to choose between getting petrified, or turning his vulnerable back on Medusa.
Warlock
* Chaotic Offering's spell immunity piercing stun can stop Black Hole's channeling. Due to this ability's large area of effect, it can be cast at a safe distance from the Black Hole. It also goes through Black King Bar and ignores Linken's Sphere.
* Fatal Bonds and Aghanim's Shard upgraded Shadow Word can be used to make Enigma's Eidolons easier to kill, potentially feeding the enemy team. Also,their constant damage will put 
Blink Dagger on cooldown, potentially forcing Enigma to prematurely activate Black King Bar.
Additional:
* Chaotic Offering pierces spell immunity and is an area of effect ability, therefore it doesn't matter if Enigma buys Black King Bar or Linken's Sphere, Warlock will always be able to cancel the channeling of 
Black Hole.
* Enemies often get clumped up around Black Hole to hit your allies, giving you a perfect opportunity to cast Fatal Bonds, Chaotic Offering, and Upheaval on multiple enemies.
Medusa
* Medusa's Split Shot can make quick work of Enigma's Eidolons and take advantage of their considerable bounty.
* Medusa can also kill Eidolons with her Mystic Snake that can also greatly damage Enigma and drain some of his mana.
* If Medusa activates Stone Gaze at the start of a fight, it can make initiating and landing an effective Black Hole exceedingly difficult, because Stone Gaze can cancel Enigma's Black Hole even through spell immunity, which can discourage Enigma from even trying to initiate with Black Hole.
Additional:
* Medusa's Split Shot can make quick work of Enigma's Eidolons and take advantage of their considerable bounty.
* If Medusa activates Stone Gaze at the start of a fight, it can make initiating — and landing an effective Black Hole exceedingly difficult. Stone Gaze can cancel Enigma's Black Hole even through spell immunity, which can discourage Enigma from initiating with Black Hole.
Warlock
* Fatal Bonds links the Meepos together, which combined with area of effect damage or Cleave will be devastating.
Medusa
* Poof won't damage Medusa and she can use Stone Gaze to disable all of Meepo's clones.
* Mystic Snake will easily become the bane of Meepo early game.
Warlock
* Heroes with summons: 
Lycan, Broodmother, Visage, Nature's Prophet, Warlock.
Medusa
* Lifestealer's low mobility makes him easy to kite.
* Stone Gaze pierces 
Rage, wasting its cooldown and making Lifestealer unable to fight.
Warlock
* Illusion and heroes with summons are difficult to kill with Chen's single-target offensive spells: Terrorblade, Phantom Lancer, Chaos Knight, Broodmother, Naga Siren, Lycan, Visage, Beastmaster, Warlock, Wraith King. And even though Chen can convert enemy summons with Holy Persuasion, their much greater numbers will often overwhelm Chen and his creeps.
Medusa
* Medusa's Split Shot can easily kill Chen's creeps.
* Mystic Snake can quickly kill Chen's creeps and deal intense damage for every killed creep while also draining their mana with each bounce. Aghanim's Scepter upgraded Mystic Snake can also disable both, Chen and his creeps upon impact.
* Mana Shield will make it impossible for Chen to burst down Medusa.
* Stone Gaze can disable Chen from using 
Hand of God to save himself or his allies.
Warlock
* Heroes with illusions and summons can be hard for Phantom Assassin to deal with, as she lacks any AoE abilities to deal with them without items: Broodmother, Phantom Lancer, Chaos Knight, Lycan, Naga Siren, Shadow Shaman, Visage, Nature's Prophet, Terrorblade, Warlock, Wraith King.
Medusa
* Heroes with disables that ignore spell immunity will render Phantom Assassin quite useless in teamfights throughout the game: 
Axe, Enigma, 
Vengeful Spirit, 
Doom, 
Bane, Beastmaster, Pudge, Medusa, Warlock.
Medusa
* Enchantress often has a small army of neutral creeps, allowing Medusa to hit her with a later bounce of her Mystic Snake.
Medusa
* Should Luna choose to buy Manta Style, Medusa will be able to kill illusions from them with Split Shot and 
Mjollnir, which is a common item on Medusa.
* Mystic Snake allows Medusa to easily harass Luna and steal mana from her, preventing Luna from retaliating with 
Lucent Beam.
* Medusa can survive 
Eclipse thanks to Mana Shield, and since Luna is not a hero that often goes for Diffusal Blade, she will struggle greatly in bursting down Medusa.
* Even with Black King Bar, Medusa's Stone Gaze will still be able to disable Luna, which could even discourage her from counter-initiating with Eclipse.
* For the same reasons, Medusa makes a very powerful ally for Luna when they are in the same team.
Additional:
* Should Luna choose to buy Manta Style, Medusa will be able to kill illusions from them with Split Shot and Mjollnir, which is a common item on Medusa.
* Mystic Snake allows Medusa to easily harass Luna and steal mana from her, preventing Luna from retaliating with Lucent Beam.
* Medusa can survive Eclipse thanks to Mana Shield, and since Luna is not a hero that often goes for Diffusal Blade, she will struggle greatly in bursting down Medusa.
* Even with Black King Bar, Medusa's Stone Gaze will still be able to disable Luna, which could even discourage her from counter-initiating with Eclipse.
* For the same reasons, Medusa makes a very powerful ally for Luna when they are in the same team.
Warlock
* Chaotic Offering's vast area-effect can destroy trees and stun Hoodwink.
* Upheaval makes retreating with 
Scurry difficult.
Medusa
* Split Shot will keep attacking Pangolier even when he is rolling around.
* Stone Gaze stuns Pangolier during Rolling Thunder, or forces him to roll away.
Warlock
* Warlock has strong counter initiation which reduces Marci's effectiveness throughout the game.
* Fatal Bonds cancels Blink Dagger, which means Marci can move in and out of fights less effectively.
* Chaotic Offering paired with Upheaval provides a ministun, a movement slow and paired with Fatal Bonds has the potential to deal a lot of damage to Marci while she jumps on a target. The ministun also means that Marci will have a harder time casting Rebound. If Warlock does build Aghanim's Scepter and 
Refresher Orb, the physical damage from Golems will overwhelm Marci, especially when played as a support.
Medusa
* Mana Shield makes it very difficult for Bloodseeker to gain his Thirst bonuses.
* Rupture rarely kills Medusa through Mana Shield.
Warlock
* Warlock is a very strong hero when positioned correctly, and his long cast range helps him with this. However, some Heroes might disrupt or sneakily pass through his allies and deal with him, preventing him from doing his job. Such heroes include Chaos Knight, Spirit Breaker, Riki, and more.
Warlock
* Heroes with summons and illusions as Spirit Breaker has no strong AoE capabilities to deal with them: Chaos Knight, Phantom Lancer, Terrorblade, Naga Siren, Broodmother, Warlock, Visage, Nature's Prophet, Shadow Shaman, Lycan.
Medusa
* If Medusa activates Stone Gaze before Spirit Breaker reaches her with Charge of Darkness, the charge will inevitably fail.
* Mana Shield and overall tankiness allows Medusa to easily survive Spirit Breaker's initiation.
Medusa
* Split Shot can destroy Tombstone Zombies and Tombstone itself while still damaging heroes.
Medusa
* Visage's familiars are easy targets to Split Shot.
* Mana Shield will resist Soul Assumption instances without effort.
Warlock
* Channeling heroes will not go well against Warlock, especially those who build Black King Bar as Warlock's ultimate ability stun goes through spell immunity. E.g.: Crystal Maiden, 
Witch Doctor, Enigma, etc.
Medusa
* Heroes with Linken's Sphere as core item: 
Weaver, 
Morphling, Medusa.
Warlock
* While heroes with strong mobility are able to get close or flee from Upheaval, heroes with no escaping abilities or that lack long disables will perish against Warlock. Once the Warlock Golem lands with its stun, its hardly possible to escape when he casts Upheaval. Notable examples: Huskar, Drow Ranger, Lion, Elder Titan, etc.
Medusa
* Any hero who can counter-initiate in anticipation without getting caught in Reverse Polarity: 
Sven, 
Omniknight, Enigma, 
Luna, Naga Siren, 
Mars, 
Jakiro, 
Venomancer, Elder Titan, 
Faceless Void, 
Rubick, 
Keeper of the Light, 
Pugna, 
Invoker, Spectre, 
Alchemist, 
Treant Protector, 
Lina, 
Oracle, 
Zeus, Shadow Shaman, 
Phoenix, 
Razor, Huskar, 
Batrider, 
Kunkka, Tidehunter, Wraith King, 
Sand King, Medusa, Dawnbreaker.
Medusa
* Heroes with a lot of burst damage, especially those who rely on casting spells: Lina, Zeus.
Warlock
* Heroes with channeling spells because Shadow Fiend has nothing to cancel channeling outside of Requiem of Souls: Bane, Enigma, Pudge, Shadow Shaman, Dawnbreaker, Warlock, Crystal Maiden.
Additional:
* Because Shadow Fiend lacks escaping mechanisms, and is dependent on fair positioning for channeling 
Requiem of Souls, it's easier for Warlock with his long range crowd control abilities to lock Shadow Fiend down for his team.
Warlock
* Channeling heroes will not go well against Warlock, especially those who build Black King Bar as Warlock's ultimate ability stun goes through spell immunity. E.g.: Crystal Maiden, Witch Doctor, Enigma, etc.
Warlock
* Viper cannot interrupt heroes with powerful channeling abilities: Bane, Enigma, Shadow Shaman, Warlock
Warlock
* Warlock often stays back and counter-initiates by dropping his Chaotic Offering on Earthshaker and his allies.
Warlock
* While heroes with strong mobility are able to get close or flee from Upheaval, heroes with no escaping abilities or that lack long disables will perish against Warlock. Once the Warlock Golem lands with its stun, its hardly possible to escape when he casts Upheaval. Notable examples: Huskar, Drow Ranger, Lion, Elder Titan, etc.
Warlock
* Heroes with both illusions and summons, for Io has nothing to deal with multiple enemies at once outside from Spirits's weak area-of-effect: Beastmaster, Broodmother, Chaos Knight, Lycan, Naga Siren, Nature's Prophet, Phantom Lancer, Shadow Shaman, Terrorblade, Visage, Warlock, Wraith King.
Medusa
* Heroes with a lot of burst damage, especially those who rely on casting spells: Lina, Zeus.
Warlock
* Supports with useful teamfight or contribution spells will be helpless against Doom: 
Dazzle, Oracle, Warlock.
Medusa
* Doom does not disable Mana Shield. As such, Doom's damage is largely mitigated by her mana shield. Additionally, Medusa is not reliant on her abilities to be effective during a teamfight, making Medusa an unproductive hero to target.
* Medusa is an ideal Linken's Sphere carrier. Should one be purchased, and without any additional disables, Doom may find that few opportunities exist to effectively lockdown, disable, and kill Medusa.
Warlock
* Heroes who rely on summons will see them destroyed easily by Overwhelming Odds: Lycan, 
Arc Warden, Warlock, 
Chen
Medusa
* Mana Shield makes Medusa very hard to take down in Duels.
* Stone Gaze stops Legion Commander from Dueling altogether, regardless of who she targets.
Medusa
* Heroes that build Diffusal Blade or can fit it well into their item build will also make Medusa much less tanky: Riki, Naga Siren, Terrorblade, Juggernaut, Spectre, Slark.
Medusa
* Medusa's Split Shot and Mystic Snake combined with Mjollnir, a common item for Medusa, will whittle down all of Naga Siren's illusions, including Naga Siren herself.
* Medusa's Stone Gaze can disable Naga Siren even for the duration of 
Song of the Siren and even if Naga Siren is spell immune, discouraging Naga Siren from even trying to use Song of the Siren to save herself or counter-initiate against Medusa.
Additional:
* Medusa's Split Shot and Mystic Snake combined with Mjollnir, a common item for Medusa, will whittle down all of Naga Siren's illusions, including Naga Siren herself.
* Medusa's Stone Gaze can disable Naga Siren even for the duration of Song of the Siren and even if Naga Siren is spell immune, discouraging Naga Siren from even trying to use Song of the Siren to save herself or counter-initiate against Medusa.
Warlock
* Heroes that have small health pools and little to no escape mechanisms are even easier prey for Necrophos. Ghost Shroud's slow will allow him to catch him with them, and get nuked down with his abilities, even preventing retaliation due to Reaper's Scythe's stun. Such heroes include Crystal Maiden, Witch Doctor, Warlock or Shadow Fiend.
Medusa
* Mana Shield can tank most of the damage from Reaper's Scythe; with sufficient mana, the kill threshold drops significantly.
* Necrophos has a movement speed equal to Medusa, and is easy to chase down with a slowing item in Medusa's inventory.
Medusa
* Heroes that build Diffusal Blade or can fit it well into their item build will also make Medusa much less tanky: Riki, Naga Siren, Terrorblade, Juggernaut, Spectre, Slark.
Warlock
* Chaotic Offering can stop heroes who like to use spell immunity and teleport scrolls to safely farm during the early to mid game, since it stuns and also goes through spell immunity. Notable examples: Juggernaut, 
Lifestealer.
Warlock
* Fragile supports with low armor are always a good prey, also her Psionic Trap will wear down most attempts to flee with their built-in disables: Silencer, Crystal Maiden, Warlock, 
Ancient Apparition, 
Grimstroke, Witch Doctor
Warlock
* Because Templar Assassin does not have escape potential in lane, any support hero with roaming potential and a 
Dust of Appearance can be great at shutting her down early game: 
Earth Spirit, Spirit Breaker, 
Tusk, 
Bounty Hunter, Riki, Warlock.
Additional:
* Warlock can cast Upheaval when Templar Assassin uses 
Meld, preventing her from escaping at the right moment.
* Warlock can also send his Warlock Golem near where she used Meld, preventing escape by Blink Dagger due to the Warlock Golem's Permanent Immolation.
* Warlock's Golem's Permanent Immolation will burn away 
Refraction with its damage over time.
Medusa
* Axe can take advantage of Medusa's awfully low HP to insta-kill her with 
Culling Blade, making it extremely difficult for her to farm for items to compensate for the lack of strength during early and mid-game while Axe is continuously harassing around.
Medusa
* Mana Shield reduces the effectiveness of Counter Helix.
* Stone Gaze makes it very difficult for Axe to initiate on Medusa and her allies.
Warlock
* With God's Strength, Warlock Golem goes down in a matter of seconds. The two weaker golems granted by Aghanim's Scepter will fare worse due to Great Cleave hitting both.
* Storm Hammer upgraded with Aghanim's Scepter dispels Shadow Word.
Additional:
* 
God's Strength combined with 
Great Cleave destroys Chaotic Offering golems within seconds.
* 
Warcry gives Sven and his allies armor to help against Warlock's Golem's heavy physical damage and movement speed to help escape Upheaval.
* 
Storm Hammer disrupts Upheaval.
Medusa
* Stone Gaze allows Medusa to easily kite and kill Sven.
* Mana Shield negates much of Sven's burst damage.
Additional:
* Mana Shield makes it very hard for Sven to burst her within Storm Hammer's stun duration.
* Stone Gaze makes it very difficult for Sven to fight Medusa at any stage of the game.
* Mystic Snake can slow Sven down enough for allies to capitalize on his commitment in a fight.
Warlock
* 
Shapeshift allows Lycan to escape from Upheaval with maximum movement speed.
* Warlock doesn't have a good solution to deal with Lycan's wolves from 
Summon Wolves.
Medusa
* Her Mana Shield is too tough for Lycan to break.
* Mystic Snake can hit for a massive damage once it spread between his summons.
Additional:
* Can be easily petrified despite his speed.
* Summoned wolves will be targeted by Split Shot or Mystic Snake
Medusa
* 
Burning Spear's damage over time can rapidly burn Medusa's mana and health alike.
* 
Inner Fire can slow and disarm Medusa and also allow Huskar to follow up with Life Break.
Warlock
* Warlock Golems do plenty of physical and pure damage to bring down Huskar when he is at low health. Warlock is always a hazard for Huskar to initiate by using 
Life Break, because Chaotic Offering can stun him instantly, even when Black King Bar is activated, and allows Warlock's team to gather their wit and retaliate.
* After using Life Break to jump in, Huskar will not have any means to escape Upheaval. Which since he is an attack-dependent hero, this will nullify his impact in fights.
Medusa
* Other heroes who has armor and slow debuffs won't allow Medusa to disengage from combat: Tidehunter, Bristleback, Slardar.
Medusa
* Medusa cares less than other heroes about armor reduction, since Mana Shield blocks 70% of all damage without taking armor/magic resistance into consideration. This makes 60% of your Corrosive Haze ineffective until Medusa's mana is drained.
Warlock
*
Impale and 
Spiked Carapace interrupts Upheaval with ease.
* Warlock's low health pool, mobility, and high intelligence gain makes him a prime target for Nyx Assassin's burst damage.
Medusa
*
Vendetta burns a significant amount of mana on hit, and the damage from the ability drains Medusa's mana pool even further.
Spiked Carapace if he's within range of Medusa's abilities and isn't invisible.
Aghanim's Scepter extremely hard to deal with if Medusa is the team's main damage source.
Split Shot, Medusa can be easily interrupted by Spiked Carapace during combat, especially during her precious 
Stone Gaze.
Mana Shield, especially if Medusa only increases her mana pool by bolstering intelligence (which has the added bonus of increasing Mana Burn's damage).
Mystic Snake and 
Split Shot can trigger Spiked Carapace.
Medusa lacks single target damage, making a Burrowed Nyx Assassin hard to kill.
* Due to the passive nature of Mystic Snake and Split Shot, it can possibly proc Nyx's
* Medusa lacks single target damage, making Nyx with
Additional:
* With her passive
* Mana Burn quickly destroys
* Uncontrollable damage from
*