* Riki is a natural Diffusal Blade carrier, and it doesn't help that he's easily capable of sneaking up on Wraith King due to Cloak and Dagger.
* Riki can use Smoke Screen on top of Wraith King as he is reincarnating, making him a sitting duck for his second life. In addition, the blind prevents Wraith King from landing critical hits from Mortal Strike.
* Wraithfire Blast is quite predictable, and if Riki can react fast, he will disjoint it with Tricks of the Trade. There is also a chance he will become invisible again as the projectile travels, disjointing it.

* With Smoke Screen, Riki will silence and catch Medusa in a surprise with high miss chance flushing her from positions easily in team fights.
* He can deal a huge amount of damage through Cloak and Dagger, even through Mana Shield.

* Broodmother can easily clear Wraith King's skeletons with Spawn Spiderlings and summon spiderlings in their place.
* With Diffusal Blade, Broodmother can prevent Wraith King from reincarnating unless Wraith King has his Aghanim's Shard.

* Webbed areas can be used to hit and run, covering distance hastily weakening her on the way and initiating ganks.
* Even though Medusa can hunt down Spiderlings easily when given enough range, Silken Bola will cause her attacks to miss and get her swarmed in no time.
* Medusa usually does not build a Black King Bar to benefit from Mana Shield fully while Broodmother can fit a Diffusal Blade to burn away all of Medusa's mana.
Additional:
* Spin Web will allow Broodmother to pick her own fights and sometimes slip away to ambush Medusa.
* Though Medusa's Split Shot and Mystic Snake can help Medusa deal with Broodmother's spiderlings, Broodmother will create too much of them for her to handle, allowing her to outnumber Medusa's targets from Split Shot and shield her team in process.

* Mana Break quickly eats away at Wraith King's small mana pool, preventing Reincarnation from triggering.
* Wraith King has no innate mobility. Even with Blink Dagger, Wraith King is easily kited by Blink.
* Anti-Mage can farm much more quickly than Wraith King, allowing Anti-Mage to overpower Wraith King once a significant farm advantage is established.
Additional:
* Mana Break can prevent Wraith King from reincarnating unless Wraith King has his Aghanim's Shard that removes the mana cost from Reincarnation.
* With Manta Style, his mana burning will triple because illusions can also use Mana Break.

* Anti-Mage easily destroys Mana Shield with Mana Break, especially once he has Manta Style.
* Anti-Mage effectively avoids Stone Gaze with Blink, and can reinitiate after its duration is over.
Additional:
* Mana Break burns Medusa's mana easily, especially when coupled with a Manta Style.
* Can easily initiate on Medusa with Blink, burning her mana or forcing her to use Stone Gaze.
* Mana Void is effective against Medusa's big mana pool and mana usage, presenting a huge hazard to Medusa's allies around her since her Mana Shield still gives her some protection if she has mana.

* Dark Pact, if timed correctly, can dispel Wraithfire Blast's stun and slow.
* Since Wraith King has a lot of health and multiple lives, Slark can keep gaining Essence Shift stacks, increasing armor, damage, and attack speed and can beat down Wraith King twice.
* Slark sometimes carries Diffusal Blade to burn mana as an attempt to shut down Reincarnation.
* Because Wraith King has no AoE abilities, Shadow Dance is particularly useful against Wraith King.

* Medusa is especially vulnerable to Essence Shift, as both strength and intelligence contribute to her effective HP, while agility contributes to her damage.
* Dark Pact when timed right can be used to dispel Stone Gaze right after it petrifies Slark, allowing him to keep attacking Medusa throughout the duration.
Additional:
* Medusa cannot chase Slark in any way and has no disable beyond her ultimate, making her unable to stop him getting away and regenerating before coming back to finish her off.
* Essence Shift particularly removes 1 intelligence point per hit, thus lowering Medusa's mana pool's cap and leaving her much more vulnerable in prolonged fights.

* Diffusal Blade lets Phantom Lancer drain Wraith King's mana, preventing Reincarnation from triggering until he buys an Aghanim's Shard.
* Wraith King is bad against illusions-based heroes, as Wraithfire Blast is his only single-target disable and can get overwhelmed easily.
* Doppelganger can disjoint Wraithfire Blast.
Additional:
* Doppelganger disjoints Wraithfire Blast.
* Wraith King is not good at handling illusion-based heroes, as his only disable is single-target.
* Phantom Lancer tends to get Diffusal Blade, leaving Wraith King no mana to reincarnate.

* Phantom Lancer with Diffusal Blade will very quickly burn Medusa's mana, making Mana Shield significantly less effective.
* Doppelganger's 1 second invulnerability can be used to dodge Medusa's petrification from Stone Gaze, as well as Mystic Snake.
* Phantom Lancer's illusions outnumber Medusa's targets from Split Shot, likely shielding his team in the process.

* EMP allows Invoker to burn Wraith King's mana to prevent Reincarnation from triggering (only until Wraith King gets his Aghanim's Shard).
* Ice Wall and Cold Snap are particularly crippling for Wraith King as they allow to kite him very effectively, preventing him from dealing melee attack damage.
Additional:
* Invoker can drain Wraith King's mana with EMP, preventing him from reincarnating unless Wraith King has his Aghanim's Shard.
* Even if Wraith King survives and reincarnates, Invoker still has an arsenal of spells to lockdown Wraith King, including an easily setup Ice Wall.
* Tornado applies an area dispel to clear skeletons.

* EMP allows Invoker to burn Medusa's mana to weaken Mana Shield.
* Medusa's lack of mobility makes her easy to kite with Invoker's spells.
Additional:
* EMP is a large mana burn nuke which can hit Medusa's Mana shield with enough damage to lose even more mana.
* Deafening Blast disarms Medusa's ability to deal pseudo-AOE damage during teamfights.
* Cold Snap allows the opposing team to repeatedly stun Medusa in short succession, preventing her from successfully casting her ultimate due to its long cast time.

* Wraithfire Blast is quite predictable, and players with good reflexes will disjoint it with Blade Fury.
* Omnislash with Diffusal Blade & Aghanim's Scepter can prevent Wraith King from reincarnating unless he has his Aghanim's Shard that removes the mana cost from Reincarnation.

* Heroes that build Diffusal Blade or can fit it well into their item build will also make Medusa much less tanky: Riki, Naga Siren, Terrorblade, Juggernaut, Spectre, Slark,Drow Ranger.

* Terrorblade has very high armor gain, which helps him against Wraith King's physical damage.
* Wraith King is not good against illusion-based heroes as he has no AoE form abilities to deal with Terrorblade's Illusions.
* Terrorblade is a common Manta Style and Diffusal Blade carrier to help deal with Reincarnation before Wraith King has Aghanim's Shard.
* A Reincarnated Wraith King is a good setup for Sunder if Terrorblade's health is low enough.
Additional:
* Wraith King has no form of AoE to clear Terrorblade's illusions.
* Terrorblade is a common Manta Style and Diffusal Blade carrier.
* Terrorblade has very high armor, which helps against Wraith King's physical-only damage.
* A reincarnated Wraith King is an ideal target for Sunder if Terrorblade's health is low.

* Heroes that build Diffusal Blade or can fit it well into their item build will also make Medusa much less tanky: Riki, Naga Siren, Terrorblade, Juggernaut, Spectre, Slark,Drow Ranger.

* Melee heroes who may struggle to get close to Sniper: Wraith King, Kunkka, Doom, Tidehunter, Underlord, Troll Warlord, and etc.

* Sniper can outrange both Medusa's arrows and Stone Gaze, allowing him to focus her down during a teamfight.
Additional:
* Medusa is a fairly immobile hero that deals damage around her with Split Shot. Sniper should outrange her and should stay out of harm's way from Split Shot.
* More importantly, Sniper should have enough attack range to fire at Medusa during her Stone Gaze without turning to stone, so the ultimate is mostly wasted against him.

* Heroes which rely exclusively on right clicks will struggle somewhat against Blinding Light: Phantom Assassin, Wraith King, Medusa

* Heroes with extremely slow movement speed will cripple against Solar Bind: Medusa, Viper

Additional:
* Will-O-Wisp will keep Medusa busy after she got hit by Blinding Light.

* He can use either his own or his double's Flux to bypass the spellblock from Linken's Sphere, using the leftover Flux + Spark Wraith to slow Medusa's already low move speed to a crawl.
* Arc Warden has a farming advantage with double Hand of Midas, and can generally bully Medusa with other items that benefit from duplication.

* Ursa's status resistance from Enrage reduces duration of Medusa's Stone Gaze.
* Ursa can stack damage with Fury Swipes easily against her Mana Shield in a prolonged team match.
Additional:
* Medusa's tankiness doesn't help her very much against Fury Swipes in long teamfights.
* With no escape mechanism and a slow movement speed, getting jumped on by Ursa usually spells a quick end for Medusa in the early game.

* With Static Link, Razor can effectively make Medusa useless in teamfights by reducing her main damage output. It can, however, be blocked by a Linken's Sphere.
* Plasma Field allows Razor to get on top of Medusa, slowing her already slow movement speed to a mere crawl.
* Eye of the Storm capitilizes on Medusa's low armor and causes her to be very vulnerable, even through Mana Shield.

* Sanity's Eclipse does massive damage to Wraith King who naturally has a low mana pool and typically doesn't build items to increase it.
* Wraithfire Blast's slow projectile speed makes it easy to avoid using Astral Imprisonment.

* Wraithfire Blast is easy to disjoint with Shukuchi or Time Lapse, and it's the only way to break Weaver's Linken Sphere.
* Wraith King has no other disables and no mobility, allowing Weaver to chase or escape Wraith King as he wishes.
* With the Mana Break talent and Diffusal Blade, Weaver can prevent Reincarnation from triggering until Wraith King gets his shard.
Additional:
* Weaver can run away after killing Wraith King once thanks to Shukuchi.
* Wraithfire Blast is quite predictable. If Weaver is quick, he will disjoint it with Shukuchi and proceed to chase Wraith King down.
* Shukuchi does have a fade time. They cannot disjoint it if you use it right next to them. They will be stunned and take damage; however they will still become invisible if they used Shukuchi before the stun hits.
* Weaver can easily harass Wraith King out of his lane thanks to his high base damage and Geminate Attack.
* Weaver can burn Wraith King's mana quickly with his Mana Break or Diffusal Blade, until Wraith King purchases Aghanim's Shard to remove Reincarnation's manacost.

* Level 4 Mana Burn burns of Medusa's mana every 5 seconds if Medusa only increases her mana pool with intelligence. Additionally, 70% of the Mana Burn damage gets mitigated by Mana Shield, burning even more mana.
* Due to the passive nature of Mystic Snake and Split Shot, it can possibly proc Nyx's Spiked Carapace if he's within range of Medusa's abilities and isn't invisible.
* Medusa lacks single target damage, making Nyx with Aghanim's Scepter extremely hard to deal with if Medusa is the team's main damage source.
Additional:
* With her passive Split Shot, Medusa can be easily interrupted by Spiked Carapace during combat, especially during her precious Stone Gaze.
* Mana Burn quickly destroys Mana Shield, especially if Medusa only increases her mana pool by bolstering intelligence (which has the added bonus of increasing Mana Burn's damage).
* Uncontrollable damage from Mystic Snake and Split Shot can trigger Spiked Carapace.
* Medusa lacks single target damage, making a Burrowed Nyx Assassin hard to kill.

* Wraith King, Medusa, Storm Spirit and other mana dependent heroes will have diminished impact on a fight if they survive Fiend's Grip due to its mana steal.

* Fiend's Grip provides mana drain, which can heavily damage Mana Shield and prevent Medusa from using Stone Gaze.
* Even if she does use Stone Gaze, Nightmare can buy enough time to protect allies and reset the fight.
Additional:
* Fiend's Grip leaves Medusa defenseless, since not only does it deal damage, it also drains mana.

* Wraith King has a very low mana pool and depends on it to cast Reincarnation. Mana Drain will render him useless.
* Wraith King has very low mobility, making it easy for Lion to disable and harass him.
Additional:
* While not being able to confront Wraith King by himself, Lion's Mana Drain helps in draining Wraith King's mana, preventing him from reincarnating unless he has his Aghanim's Shard.
* Lion's Earth Spike and Hex provide decent lockdown against Wraith King as well, preventing the latter from benefiting from Vampiric Spirit bonuses.

* Medusa lacks mobility or escape mechanisms. Earth Spike and Hex can neutralize her strong damage potential and allow for Lion's team to focus her down.
* In addition to easily breaking her commonly bought Linken's Sphere with its low cooldown, Mana Drain can quickly drain her Mana Shield, making her far less tanky.

* Heroes who rely on basic attacks will suffer from Laser: Phantom Assassin, Wraith King, Huskar.

* Clinkz, Sniper, Lone Druid, Troll Warlord, Legion Commander and Wraith King are some of the Heroes that base themselves on attacks with little or no spell power, so they suffer in the grassy hands of Overgrowth.

* Heroes with area dispel can kill multiple skeletons at once: Brewmaster, Oracle.

* Heroes with area dispel can kill multiple skeletons at once: Brewmaster, Oracle.

* Heroes that build Diffusal Blade or can fit it well into their item build will also make Medusa much less tanky: Riki, Naga Siren, Terrorblade, Juggernaut, Spectre, Slark,Drow Ranger.

* In general, attacks of the melee heroes who are entirely reliant on dealing physical damage and/or have very little to no area-of-effect abilities will make Underlord tickle and will have no effect against him, and will be unable to ambush Underlord and his team if Underlord chooses to use Dark Rift to get to a designated point of the map: Phantom Assassin, Terrorblade, Troll Warlord, Drow Ranger, Phantom Lancer, Chaos Knight, Sven, Wraith King, Bounty Hunter, Alchemist, Templar Assassin, Nyx Assassin, Bane.

* Heroes that build Diffusal Blade or can fit it well into their item build will also make Medusa much less tanky: Riki, Naga Siren, Terrorblade, Juggernaut, Spectre, Slark,Drow Ranger.

* Jakiro's area-of-effect abilities make him strong against heroes who rely on illusions and summons: Terrorblade, Naga Siren Chaos Knight, Phantom Lancer, Broodmother, Nature's Prophet, Lycan, Wraith King, Visage.

* Hard carries who just want to farm and be left alone will not appreciate Primal Beast, heroes such as Medusa, Drow Ranger...

* Other heroes who has armor and slow debuffs won't allow Medusa to disengage from combat: Tidehunter, Bristleback, Slardar.

* Many physical-only single-target heroes like Lifestealer, Sven, Wraith King, Phantom Assassin, Templar Assassin can have their damage mitigated by Cold Embrace.

* Heroes who can delivers a big chunk of damage in few hits will find themselves struggle against Templar Assassin's Refraction: Sven, Phantom Assassin, Ursa, Wraith King, Lifestealer

* Phantasm gives Chaos Knight a significant advantage against single-target damage dealers: Lifestealer, Wraith King, Night Stalker, Troll Warlord.

Additional:
* Wraith King has no form of AoE to clear Chaos Knight's illusions from Phantasm.
* Wraith King is very vulnerable if he reincarnates in the middle of his illusions.

* Heroes who are reliant on physical damage will be nullified by Decrepify: Riki, Wraith King, Juggernaut.

* Heroes that lack burst damage will have a difficult time taking down Monkey King, and fare badly against Jingu Mastery: Legion Commander, Lifestealer, Weaver, Wraith King

Additional:
* Wraith King has no ability to destroy trees from Tree Dance.
* Monkey King tends to get Diffusal Blade, leaving Wraith King no mana to reincarnate unless Wraith King has his Aghanim's Shard.
* A reincarnated Wraith King is an ideal target for Wukong's Command.

* Other heroes who has armor and slow debuffs won't allow Medusa to disengage from combat: Tidehunter, Bristleback, Slardar.

* Silencer burns easily through her effective HP from Mana Shield, by taking away her intelligence.
* Arcane Curse punishes her repeatedly casting Mystic Snake to keep her mana pool high. He can force her to use Manta Style before he has cast Global Silence and Medusa usually does not want to build Black King Bar.

* Wraith King's lack of area of effect spells makes him easily overwhelmed by Beastmaster's summons.

* Bulwark can make each of Medusa's attacks target him instead, reducing Medusa's contribution on team fights.
* Spear of Mars stuns Medusa and also pushes her away from teamfights, taking advantage of Medusa's low mobility.
* Arena Of Blood blocks Medusa's attacks from outside the arena.

* Heroes with summons and illusions such as Broodmother and Naga Siren, are ill-suited for Wraith King to fight, as he has no source of waveclear.

* Heroes that build Diffusal Blade or can fit it well into their item build will also make Medusa much less tanky: Riki, Naga Siren, Terrorblade, Juggernaut, Spectre, Slark,Drow Ranger.